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More About This Textbook
Overview
Written in a clear and engaging style, and profusely illustrated with superb computer graphics, Introduction to Protein Architecture is a textbook for second and third year undergraduate students and beginning post-graduate students, and will be of interest to all biological and medical scientists whose work touches on proteins.
The structures and functions of proteins unlock the secrets inherent in genomes, including the human genome. The emphasis of this book is on protein architecture, on proteins as three-dimensional patterns. A new field, bioinformatics, has grown up around gene and protein sequences and structures. It has captured the interest of many scientists for its intellectual challenges, its potential for useful applications, and promising scope for careers. This book introduces the use of the World Wide Web in bioinformatics.
Written by one of the leaders in this field, Introduction to Protein Architecture explains the general characteristics of proteins that underlie the very great variety of folding patterns observed in nature. For specialists in structural biology, it contains the core of what they need to know. For students and workers in related disciplines, undergraduates or beginning graduate students in biology, chemistry, medicine, bioinformatics, and related fields it contains what they will be able to apply to their own work. Topics treated include: Pattern and form in protein structure; The building blocks; The relationship between amino acid sequence and protein structure; Secondary, supersecondary and tertiary structure; Classifications and hierarchies of protein folding patterns; Protein evolution; How proteins change conformation (and why).
To suit the needs of courses, each chapter includes recommended reading, lists of useful web sites, traditional exercises, and a new type of exercise called a weblem, for WEB-based probLEM.
The book contains predominantly color illustrations, with some black-and-white illustrations.
Editorial Reviews
From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)Description: This book presents information on protein structure.
Purpose: This up-to-date book is intended for advanced undergraduates or beginning graduate students.
Audience: Besides serving as a textbook for students, this book also can be used as a reference source for investigators wishing to access current thinking and databases used in the study of protein structure.
Features: The book begins with an introduction based on the crystal structure of the bacterial photosynthetic reaction center. This formidable complex serves to illuminate many key aspects of protein organization and to impress the reader with the sophistication not only of the structure itself but of the methods used to define it. A general discussion of protein conformation is next, followed by sections highlighting the various motifs present in proteins. Concluding chapters highlight specific proteins such as immunoglobulins and T-cell receptors and mechanisms of conformational change. Each chapter is accompanied by a short bibliography and a problem set, some of which require use of the Internet. An appendix has a set of figures of protein structures. The extensive illustrations are almost all based on computer representations and are presented as stereo views. The success of the text depends to a significant extent on the ability of the reader to access these views — a stereo viewer is strongly recommended.
Assessment: This is an excellent introduction to protein structure and will serve students well. Particularly valuable is the use of databases and the web. A shortcoming is the failure of the author to address issues of post-translational modifications such as glycosylation, lipidation, or phosphorylation. This is regrettable since it is estimated that 50 percent or more of eukaryotic proteins are so modified and in many cases these alterations are critical structural determinants.
From the Publisher
"A text for second- and third-year undergraduate students and beginning post-graduate students in biological and medical science, incorporating an introduction to the use of the Web in bioinformatics. Explains the general characteristics that underlie all structures, functions, and interactions of proteins observed in nature. Emphasis is on protein architecture and the three-dimensional patterns of protein structures, with a wealth of computer-generated color images. Includes exercises, problems, and 'weblems,' designed to give students practice with the tools required for research in the field. The author is affiliated with the University of Cambridge."--SciTech Book News
"In An Introduction to Protein Architecture, Arthur Lesk presents an insightful survey of this most fundamental topic. It is particularly timely for a new text on this subject as the current availability of extensive web-based information resources for protein sequences and structures modifies the traditional role for the textbook. Arthur Lesk is one of the pioneers of the analysis of protein structure and its evolution. ... So, needless to say, this book is brilliantly illustrated with an extensive array of large, clear stereo diagrams for the structures or motifs that are described in the text. Moreover, we believe that the use of stereo figures is essential for truly visualizing the complex 3D geometry of proteins. ... [T]his text, written by a leading expert in the field, is to be highly recommended for anyone wishing to learn about protein architecture in the context of the current structure of bioinformatics information resources."--Trends in Biochemical Sciences
Booknews
A text for second- and third-year undergraduate students and beginning post-graduate students in biological and medical science, incorporating an introduction to the use of the Web in bioinformatics. Explains the general characteristics that underlie all structures, functions, and interactions of proteins observed in nature. Emphasis is on protein architecture and the three-dimensional patterns of protein structures, with a wealth of computer-generated color images. Includes exercises, problems, and "weblems," designed to give students practice with the tools required for research in the field. The author is affiliated with the University of Cambridge. Annotation c. Book News, Inc., Portland, OR (booknews.com)3 Stars from Doody
Product Details
Related Subjects
Table of Contents
Chapter 1: The photosynthetic reaction centre: protein structure in a microcosm
The reaction centre from Rhodopseudomonas viridis
Conclusions
Chapter 2: In vivo, in vitro, in silicio
Why study proteins?
Protein structure and conformation The known protein structures The Protein Data Bank The World Wide Web Summary Glossary
Chapter 3: Pattern and form in protein structure
Helices and sheets The hierarchical nature of protein architecture An album of small structures Classification of protein structures Loops Protein-ligand interactions
Chapter 4: The varieties of protein structure
Catalogues of protein structure The known structures
*a-helical proteins
*B-sheet proteins
*a + *B proteins
*a / *B proteins Closed *B-*a-*B barrel structures Irregular structures Conclusions
Chapter 5: Molecular evolution
Evolution of DNA and proteins Evolution of protein structures Structural relationships among related molecules
Chapter 6: Evolution in selected protein families
Evolution of the globins Evolution of serine proteinases of the chymotrypsin family NAD-binding domains of dehydrogenases
Chapter 7: Some proteins of the immune system
Antibody structure Proteins of the Major Histocompatibility Complex T-cell receptors
Chapter 8: Conformational changes in proteins
Structural changes arising from change in state of ligation Hinge motions in proteins The 'helix interface shear' mechanism of conformational change The allosteric change in haemoglobin Serpins: SERine Proteinase INhibitors Higher-level structural changes
Appendix 1: An album for browsing
Appendix 2: Useful web sites