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Doody's Review ServiceReviewer: Candace J. Krepel, MS (Medical College of Wisconsin)
Description: This text provides an excellent overview of protein structure and how structure and function interrelate. The previous edition was published in 1991.
Purpose: The purpose is to convey an understanding of protein structure as a basis for the understanding of biological reactions.
Audience: The text is written at a content level consistent with advanced undergraduates or above. A basic knowledge of proteins and their biological function is assumed.
Features: Basic protein structure (primary, secondary, etc.) is reviewed, followed by elucidation of the structures of examples from various protein families (that is, proteins with common functions), and to demonstrate how function follows form. The editors use excellent interrelated illustrations that allow the reader to understand the three-dimensional aspects of the structures. Amino acid sequence is listed, secondary structure of alpha helixes and beta sheets are shown, then three-dimensional models and drawings demonstrate the tertiary structure. The editors use these to show how the proteins intersect and interact with the biological environment. They do an excellent job of showing proteins as being an important part of the living organism.
Assessment: The text offers an up-to-date look at what is known about protein structure and the methodologies for determining structure. The editors use well-chosen paradigms as examples. In this rapidly growing field, this new edition is welcome.