Investigations

Paperback (Print)
Buy Used
Buy Used from BN.com
$23.52
(Save 41%)
Item is in good condition but packaging may have signs of shelf wear/aging or torn packaging.
Condition: Used – Good details
Used and New from Other Sellers
Used and New from Other Sellers
from $1.99
Usually ships in 1-2 business days
(Save 95%)
Other sellers (Paperback)
  • All (30) from $1.99   
  • New (12) from $6.96   
  • Used (18) from $1.99   

Overview

"It may be that I have stumbled upon an adequate description of life itself."

These modest yet profound words trumpet an imminent paradigm shift in scientific, economic, and technological thinking. In the tradition of Schrodinger's classic What Is Life?, Kauffman's Investigations is a tour-de-force exploration of the very essence of life itself, with conclusions that radically undermine the scientific approaches on which modern science rests—the approaches of Newton, Boltzman, Bohr, and Einstein.

Building on his pivotal ideas about order and evolution in complex life systems, Kauffman finds that classical science does not take into account that physical systems—such as people in a biosphere—effect their dynamic environments in addition to being affected by them. These systems act on their own behalf as autonomous agents, but what defines them as such? In other words, what is life? Kauffman supplies a novel answer that goes beyond traditional scientific thinking by defining and explaining autonomous agents and work in the contexts of thermodynamics and of information theory. Much of Investigations unpacks the progressively surprising implications of his definition. Significantly, he sets the stages for a technological revolution in the coming decades. Scientists and engineers may soon seek to create autonomous agents—both organic and mechanical—that can not only construct things and work, but also reproduce themselves! Kauffman also lays out a foundation for a new concept of organization, and explores the requirements for the emergence of a general biology that will transcend terrestrial biology to seek laws governing biospheres anywhere in the cosmos. Moreover, he presents four candidate laws to explain how autonomous agents co-create their biosphere and the startling idea of a "co-creating" cosmos.

A showcase of Kauffman's most fundamental and significant ideas, Investigations presents a new way of thinking about the fundamentals of general biology that will change the way we understand life itself—on this planet and anywhere else in the cosmos. "I have watched the long gestation of Investigations with some apprehension but more anticipation. Its reach is gigantic, from the most primitive origins of life to the macroeconomics of innovation. What comes up in its grasp is original and stimulating. This is a must read for anyone interested in the outer edges of understanding of the world around us.
—(Philip Anderson, Nobel Laureate, Princeton University)

About the Author:
Stuart Kauffman, winner of the MacArthur "genius" award, is a founding member of the Santa Fe Institute, the leading center for the emerging sciences of complexity. A major force in science and its applications to the business world, he formed BiosGroup LP in 1996 in partnership with Ernst & Young. The author of previous bestsellers Origins of Order and At Home in the Universe, he lives in Santa Fe, New Mexico.

Read More Show Less

Editorial Reviews

From the Publisher

"I have watched the long gestation of Investigations with some apprehension but more anticipation. Its reach is gigantic, from the most primitive origins of life to the macroeconomics of innovation. What comes up in its grasp is original and stimulating. This is a must read for anyone interested in the outer edges of understanding of the world around us."--Philip Anderson, Nobel Laureate, Princeton University

"A fascinating exploration of the very essence of life itself."--Forecast

Read More Show Less

Product Details

  • ISBN-13: 9780195121056
  • Publisher: Oxford University Press, USA
  • Publication date: 9/28/2002
  • Edition description: New Edition
  • Pages: 308
  • Product dimensions: 8.97 (w) x 5.84 (h) x 0.78 (d)

Meet the Author

Stuart Kauffman, winner of the MacArthur "genius" award, is a founding member of the Santa Fe Institute, the leading center for the emerging sciences of complexity. A major force in science and its applications to the business world, he formed BiosGroup LP in 1996 in partnership with Ernst & Young. The author of previous bestsellers Origins of Order and At Home in the Universe, he lives in Santa Fe, New Mexico.

Read More Show Less

Read an Excerpt

1. Prolegomenon to a General Biology

Lecturing in Dublin, one of the twentieth century's most famous physicists set the stage of contemporary biology during the war-heavy year of 1944. Given Erwin Schrodinger's towering reputation as the discoverer of the Schrodinger equation, the fundamental formulation of quantum mechanics, his public lectures and subsequent book were bound to draw high attention. But no one, not even Schrodinger himself, was likely to have foreseen the consequences. Schrodinger's What Is Life? is credited with inspiring a generation of physicists and biologists to seek the fundamental character of living systems. Schrodinger brought quantum mechanics, chemistry, and the still poorly formulated concept of "information" into biology. He is the progenitor of our understanding of DNA and the genetic code. Yet as brilliant as was Schrodinger's insight, I believe he missed the center. Investigations seeks that center and finds, in fact, a mystery.

In my previous two books, I laid out some of the growing reasons to think that evolution was even richer than Darwin supposed. Modern evolutionary theory, based on Darwin's concept of descent with heritable variations that are sifted by natural selection to retain the adaptive changes, has come to view selection as the sole source of order in biological organisms. But the snowflake's delicate sixfold symmetry tells us that order can arise without the benefit of natural selection. Origins of Order and At Home in the Universe give good grounds to think that much of the order in organisms, from the origin of life itself to the stunning order in the development of a newborn child from a fertilized egg, does not reflectselection alone. Instead, much of the order in organisms, I believe, is self-organized and Spontaneous. Self-organization mingles with natural selection in barely understood ways to yield the magnificence of our teeming biosphere. We must, therefore, expand evolutionary theory.

Yet we need something far more important than a broadened evolutionary theory. Despite any valid insights in my own two books, and despite the fine work of many others, including the brilliance manifest in the past three decades of molecular biology, the core of life itself remains shrouded from view. We know chunks of molecular machinery, metabolic pathways, means of membrane biosynthesis-we snow many of the parts and many of the processes. But what makes a cell alive is ;till not clear to us. The center is still mysterious.

And so I began my notebook "Investigations" in December of 1994, a full half century after Schrodinger's What Is Life?, as an intellectual enterprise unlike any I had undertaken before. Rather bravely and thinking with some presumptuousness :)f Wittgenstein's famous Philosophical Investigations, which had shattered the philosophical tradition of logical atomism in which he had richly participated, I retook myself to my office at home in Santa Fe and grandly intoned through my fingers onto the computer's disc, "Investigations," on December 4,1994. I sensed my long search would uncover issues that were then only dimly visible to me. I toped the unfolding, ongoing notebook would allow me to find the themes and .ink them into something that was vast and new but at the time inarticulate.

Two years later, in September of 1996, I published a modestly well-organized version of Investigations as a Santa Fe Institute preprint, launched it onto the web, and put it aside for the time being. I found I had indeed been led into arenas that I tad in no way expected, led by a swirl of ever new questions. I put the notebooks aside, but a year later I returned to the swirl, taking up again a struggle to see some:hing that, I think, is right in front of us-always the hardest thing to see. This book is the fruit of these efforts. And this first chapter is but an introduction, in brief, to :he themes that will be explained more fully in the following chapters. I would ask :he reader to be patient with unfamiliar terms and concepts.

My first efforts had begun with twin questions. First, in addition to the known laws of thermodynamics, could there possibly be a fourth law of thermodynamics For open thermodynamic systems, some law that governs biospheres anywhere in :he cosmos or the cosmos itself? Second, living entities-bacteria, plants, and animals-manipulate the world on their own behalf: the bacterium swimming upstream in a glucose gradient that is easily said to be going to get "dinner"; the paramecium, cilia beating like a Roman warship's oars, hot after the bacterium; we humans earning our livings. Call the bacterium, paramecium, and us humans "autonomous agents," able to act on our own behalf in an environment.

My second and core question became, What must a physical system be to be an autonomous agent? Make no mistake, we autonomous agents mutually construct our biosphere, even as we coevolve in it. Why and how this is so is a central subject of all that follows.

From the outset, there were, and remain, reasons for deep skepticism about the enterprise of Investigations. First, there are very strong arguments to say that there can be no general law for open thermodynamic systems. The core argument is simple to state. Any computer program is an algorithm that, given data, produces some sequence of output, finite or infinite. Computer programs can always be written in the form of a binary symbol string of 1 and o symbols. All possible binary symbol strings are possible computer programs. Hence, there is a countable, or denumerable, infinity of computer programs. A theorem states that for most computer programs, there is no compact description of the printout of the program. Rather, we must just unleash the program and watch it print what it prints. In short, there is no shorter description of the output of the program than that which can be obtained by running the program itself. If by the concept of a "law" we mean a compact description, ahead of time, of what the computer program will print then for any such program, there can be no law that allows us to predict what the program will actually do ahead of the actual running of the program.

The next step is simple. Any such program can be realized on a universal Turing machine such as the familiar computer. But that computer is an open nonequilibrium thermodynamic system, its openness visibly realized by the plug and power line that connects the computer to the electric power grid. Therefore, and I think this conclusion is cogent, there can be no general law for all possible nonequilibrium thermodynamic systems.

So why was I conjuring the possibility of a general law for open thermodynamic systems? Clearly, no such general law can hold for all open thermodynamic systems.

But hold a moment. It is we humans who conceived and built the intricate assembly of chips and logic gates that constitute a computer, typically we humans who program it, and we humans who contrived the entire power grid that supplies the electric power to run the computer itself. This assemblage of late-twentiethcentury technology did not assemble itself. We built it.

On the other hand, no one designed and built the biosphere. The biosphere got itself constructed by the emergence and persistent coevolution of autonomous agents. If there cannot be general laws for all open thermodynamic systems, might there be general laws for thermodynamically open but self-constructing systems such as biospheres? I believe that the answer is yes. Indeed, among those candidate laws to be discussed in this book is a candidate fourth law of thermodynamics for such self-constructing systems.

To roughly state the candidate law, I suspect that biospheres maximize the average secular construction of the diversity of autonomous agents and the ways those agents can make a living to propagate further. In other words, on average, biospheres persistently increase the diversity of what can happen next. In effect, as we shall see later, biospheres may maximize the average sustained growth of their own "dimensionality."

Thus, the enterprise of Investigations soon began to center on the character of the autonomous agents whose coevolution constructs a biosphere. I was gradually led to a labyrinth of issues concerning the core features of autonomous agents able to manipulate the world on their own behalf. It may be that those core features capture a proper definition of life and that definition differs from the one Schrodingerfound.

To state my hypothesis abruptly and without preamble, I think an autonomous agent is a self-reproducing system able to perform at least one thermodynamic work cycle. It will require most of this book to unfold the implications of this tentative definition.

Following an effort to understand what an autonomous agent might bewhich, as just noted, involves the concept of work cycles-I was led to the concepts of work itself, constraints, and work as the constrained release of energy. In turn, this led to the fact that work itself is often used to construct constraints on the release of energy that then constitutes further work. So we confront a virtuous cycle: Work constructs constraints, yet constraints on the release of energy are required for work to be done. Here is the heart of a new concept of "organization" that is not covered by our concepts of matter alone, energy alone, entropy alone, or information alone. In turn, this led me to wonder about the relation between the emergence of constraints in the universe and in a biosphere, and the diversification of patterns of the constrained release of energy that alone constitute work and the use of that work to build still further constraints on the release of energy. How do biospheres construct themselves or how does the universe construct itself? ...

Read More Show Less

Table of Contents

Preface
1 Prolegomenon to a General Biology 1
2 The Origins of Life 23
3 Autonomous Agents 49
4 Propagating Organization 81
5 A Physics of Semantics? 109
6 Emergence and Story: Beyond Newton, Einstein, and Bohr? 119
7 The Nonergodic Universe: The Possibility of New Laws 141
8 Candidate Laws for the Coconstruction of a Biosphere 159
9 The Persistently Innovative Econosphere 211
10 A Coconstructing Cosmos? 243
Epilogue 267
References 271
Index 273
Read More Show Less

Interviews & Essays

Essay by Stuart Kauffman
Investigations is, without a doubt, the strangest intellectual adventure of my scientific career. I began in 1994 keeping a running notebook to capture some dozen or more strands of thought, hoping they might eventually cohere into a vision of something that is right in front of us but inarticulate and virtually invisible. I hope I have succeeded. I began with a novel question: Consider a bacterium swimming upstream in a glucose gradient. We all unhesitatingly say that the bacterium is going to get food. That is, the bacterium is acting on its own behalf in an environment. I will call a system such as the bacterium able to act on its own behalf an "autonomous agent." All free-living organisms are autonomous agents. The stunning fact is that we do, every day, manipulate the universe on our own behalf. Yet nowhere in physics, or chemistry, nor yet in biology, is this fact accounted for. Further, the bacterium is "just" a physical system, and we are not vitalists. So my question became: What must a physical system be such that it can act on its own behalf, be an autonomous agent? After weeks of struggle I came to a tentative definition: An autonomous agent is a system capable of self-reproduction and also capable of carrying out one or more thermodynamic work cycles. In Investigations I work toward this definition and give a first example of a chemical autonomous agent. At a minimum, I have pointed to a new class of chemical reaction networks, ones that presage a technological revolution, for we must soon synthesize such systems, hence will soon create chemical reproducing systems that actually are able to build and construct.

It may be that I have stumbled upon an adequate definition of life itself. If so, here is the inner core, the mysterious center that has not been revealed despite the brilliance of contemporary molecular biology. Much of Investigations proceeds to study the consequences of this definition, which come to include a critique of the physicist's notion of "work," for work is, in fact, the constrained release of energy, such as a cylinder with a piston in it, where the expanding gas in the head of the cylinder does work pushing on the piston. But the catch lies in the fact that it typically takes work to construct the constraints, and the constraints to allow work to happen. Here we have a conceptual cycle, unanalyzed in physics or elsewhere that, I believe, lies at the heart of an adequate concept of organization itself. You see, a propagating microbial community is doing something that is not matter alone, energy alone, entropy alone, or information alone, but something new and undefined in current science. It is a propagating organization that builds and constructs more of itself. Investigations explores that "something," then finds and explicates a mystery at the core of life. Among the most astonishing consequences of Investigations is a conclusion I think is correct, yet one that disturbs me deeply: The way Newton, Boltzmann, Einstein, and Bohr taught us to do science may not be adequate to the persistent evolution of a biosphere. These scientists have taught us that we can prestate the space of possibilities, the configuration space, of the system being studied. But I do not think this claim holds for a biosphere. I do not think we can finitely prestate the configuration space of a biosphere. Life may be doing something nonalgorithmic, literally incalculable and persistently creative. If so, we must rethink science itself and its relation to the humanities.

Investigations explores a widening circle of issues: the physical nature of propagating organization, a strange incompleteness in the famous "Maxwell Demon" problem that raises questions about the buildup and diversification of life in a biosphere, whether autonomous agents are the minimal entities about which concepts of "value" can be applied, hence a physics of semantics, about the vastly nonrepeating character of the universe at levels of complexity of complex molecules and above, hence about the "adjacent possible" into which the biosphere and the "econosphere" persistently stumble, and whether there may be general laws governing biospheres wherever they may arise in the cosmos. Indeed, I hazard four candidate laws, including a candidate fourth law of thermodynamics for self-constructing systems such as biospheres: Biospheres, as an average, or secular trend, may become as diverse as possible, maximizing the diversity of "what can happen next." In effect, biospheres may maximize the average growth in their own dimensionality.

I go beyond these topics in Investigations to discuss both the core of economics and cosmogenesis. Caveats: I am a biologist, not an economist or a physicist. But we are routinely taught that economics is the science of the allocation of scarce resources. Yet the most stunning feature of the global economy over the past 200,000 years is the vast explosion of diversity of goods and services, from perhaps a dozen to hundreds of millions. The econosphere may also be maximizing the growth of the diversity of "what can happen next," and the main story of economics is the persistent discovery of new ways of making a living as new goods enter and old goods go extinct in "Schumpterian gales of creative destruction."

About cosmogenesis: I devote a chapter at the end to exploring parallels between self-constructing biospheres and the question of whether the cosmos as a whole co-constructs itself, including choosing the very laws that govern its behavior. This chapter is not clearly wrong but should be considered with caution.

Overall, I find Investigations deeply puzzling. I think I am correct in what I say; I think Investigations points toward dimly glimpsed issues that will come to occupy 21st-century science. I am proud of the book but remain quizzical about it. If I have opened new, useful doors, others will pass through, and this line of science will come to flourish as part of a general biology, a biology freed from the confines of terrestrial biology, and it will serve as an impetus to raise physics up to the level at which it can discuss autonomous agents, physical systems such as physicists able to manipulate the world on their own behalf.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously
Sort by: Showing all of 2 Customer Reviews
  • Anonymous

    Posted November 6, 2002

    The Source of Nature's Complexity

    Stuart Kauffman's book, Investigations, is based on the not-so-novel observation that the universe is complex, and his investigations are aimed at finding out why the universe is complex, and where its complexity comes from. He is well aware of the fact that in such astonishingly complex biological systems as human beings the source of complexity is contained in the "free-living cell" or "autonomous agent" that controls the development of the organism, but he fails to apply that common knowledge to the solution of complexity's origin and purpose in the universe. The principal reason for that failure is most obvious: Kauffman is still handicapped by the evidenceless origin-of-life premise. As a matter of fact he dedicates an entire chapter to the discussion of the absurdity that nonlife is the cause of life. He seems to ignore the fact that he is violating biogenesis, the most basic fact of biology, i.e. "The principle that a living organism can only arise from other living organisms similar to itself (i.e. that like gives rise to like) and can never originate from nonliving material" (Oxford Dictionary of Science, 4th ed., Oxford University Press, 1999). Ironically the publisher of Investigations is also Oxford University Press. In any case this long-held principle is still valid, and so far as we know it has never been violated in fact. The point I want to make is that Stuart Kauffman should have made a bit more investigation in real nature, not only in the world of computer simulations. When he wonders why our world is so complex, and where its complexity comes from, it may be likened to an apple wondering why the apple tree is so complex, and where its complexity comes from. Even if apples could investigate the source of the tree's complexity, they would not be able to put a finger on that seed which generated the tree for the production of seeds in its own image. Consequently they would have the illusion that the earth's lifeless elements self-organized themselves into a tree system, and that the tree's nonliving materials somehow self-organized themselves into a most primitive life form that eventually evolved into leaves, the leaves into flowers, and the flowers into seeds. Only an outside observer--who can follow the tree's development from seed to seeds--could enlighten the apples that the tree is complex because it was generated for the production of seeds, and the source of that complexity is a seed akin to the tree's seeds or output. What is true in the case of a tree system, it is also true in the case of the world system: The universe is complex because a seed of human life generated the world system for the production of human life in its own image. And because human life is the seed or ultimate source of the universe, the universe has no power to act upon the cause of its own origin, just as a tree has no power to act upon the seed of its own origin. This simple and elegant "supertheory," which Kauffman and others desired to find, is falsifiable in case we discover a life form vastly superior to human life. In that case the revised supertheory will read: Superlife generated the universe for the production of superlife in its own image. In the final analysis the postulate that a seed of human life generated the universe for the purpose of self-reproduction is in harmony with the principle of biogenesis; with the fact that the formation of structures is the basic quality of life and not that of nonlife; and with the observations that the values of the universe are fine-tuned for the production of human life, just as the values of a tree are fine-tuned for the production of seeds. Due to the fact that Kauffman argues that the complexity of our world arises spontaneously from simplicity, his Investigations is a must read for anyone who wants to learn that those who derive the source of complexity and life from simplicity can only argue that the cause can have an effect with more in it than is found in th

    0 out of 1 people found this review helpful.

    Was this review helpful? Yes  No   Report this review
  • Anonymous

    Posted July 22, 2011

    No text was provided for this review.

Sort by: Showing all of 2 Customer Reviews

If you find inappropriate content, please report it to Barnes & Noble
Why is this product inappropriate?
Comments (optional)