Ion Channels: From Atomic Resolution Physiology to Functional Genomics No. 245 / Edition 1

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Ion channels provide a unique opportunity to use computational approaches to attempt an understanding of the function of a membrane protein, starting with an atomic resolution structure and progressing through a hierarchy of theoretical descriptions until one can account quantitatively for their physiological function. This book brings together physiologists, structural biologists and theorists who came together to help define the direction of the field in the immediate future.
Topics covered include:
* the x-ray structure of channels and pores
* computer simulation of channel function
* detailed data on potassium channels, chloride and calcium channels, and ligand-gated ion channels

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Editorial Reviews

From the Publisher
"…I would particularly recommend it to students who wish to gain a flavour of the discussions, disputes and personalities within this field…" (The Biochemist, 31 March 2003)
From The Critics
Mutations in ion channels may contribute to several neurological and muscular diseases. This collection of 15 papers from the June 2001 symposium reviews progress in understanding the relationship between the structure and function of ion channels. New developments are presented in the structure of specific ion channels, the study of functions at the microscopic level, and the role of genomics. Topics include channel-like transporter proteins from the aquaporin family, the simulation of water in ion channels and pores, permeation energetics in a model potassium channel, and the use of EPR spectroscopy to analyze the KcsA gating mechanism. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780470843758
  • Publisher: Wiley
  • Publication date: 5/28/2002
  • Series: Novartis Foundation Symposia Series, #196
  • Edition number: 1
  • Pages: 284
  • Product dimensions: 6.18 (w) x 9.39 (h) x 0.72 (d)

Table of Contents

Introduction: stretching the envelope in structure-function studies of ion channels (M. Sansom)

Structure of acetylcholine-gated channel (N. Unwin)

The 2.7 A structure of AChBP, homologue of the ligand-building domain of the nicotonic acetylcholine receptor (K. Brejc, et al.)

The architecture of a water-selective pore in the lipid bilayer visualized by electron crystallography in vitreous ice (A. Mitra, et al.)

The structure of Glpf, a glycerol conducting channel (D. Fu, et al.)

Water in ion channels and pores—simulation studies (M. Sansom, et al.)

What can be deduced about the structure of Shaker from available data? (B. Roux)

Permeation energetics in a model potassium channel (S. Garofoli, et al.)

The β subunit of Kv1 channels: voltage-gated enzyme or safety switch? (J. Gulbis)

EPR approaches to ion channel structure and function (E. Perozo, et al.)

Excitability is mediated by the T1 domain of the voltage-gated potassium channel (S. Choe, et al.)

Structural organization of the voltage sensor in voltage-dependent potassium channels (D. Papazian, et al.)

Electron diffraction of a bacterial CIC -type chloride channel (M. Pirruccello, et al.)

A protein chemical approach to channel structure and function: the proton channel of the vacuolar H+-ATPase (J. Findlay and M. Harrison)

Acetylcholine receptors, between closed and open (A. Auerbach)

Functional genomics of ionotropic acetylcholine receptors in Caenorhabditis elegans and Drosophilia melanogaster (D. Satelle et al.)

Final General Discussion

Index of Contributors

Subject Index

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