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Doody's Review ServiceReviewer: Omer Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: This well-illustrated book provides a comprehensive look at the latest basic and clinical developments on the involvement of Jak-Stat pathway in the regulation of cell development, differentiation, proliferation and apoptosis, the malfunctioning of which results in hematopoietic malignancies and cancer.
Purpose: Although not clearly stated, the purpose is to assemble chapters from leaders in the field of Jak-Stat signaling, many of whom were participants in a 2010 meeting in Vienna on this topic, to provide insights into developments.
Audience: The book is intended for all scientists in molecular biology, biochemistry, and cell biology dealing with biomedical issues. In my opinion, clinical oncologists also will find this book useful.
Features: Following an introductory chapter on the continuing fascination with JAK tyrosine kinases and STAT transcription factors, the chapters in the first part of the book deal with recent findings and new technologies pertaining to basics of Jak-Stat function. The chapters in the second part discuss the evolution of Jak-Stat signaling and the role of the pathway in invertebrate organisms. The chapters in the third part deal with Jak-Stat signaling in hematopoietic cells under both physiological and pathophysiological conditions. Chapters in the fourth part explore the relationship of Jak-Stat signaling to various diseased states, particularly infection, leukemias, and solid cancerous tumors. The concluding chapters cover the activation and inhibition of Jak-Stat signal transduction by RNA viruses; multifaceted antiviral actions of interferon-stimulated gene products; and interferon regulation of the innate response to bacteria. The book is well-illustrated with a number of beautiful color figures.
Assessment: This is an excellent resource on the involvement of the Jak-Stat pathway in cell development, differentiation, proliferation, and apoptosis from basic science to disease. Molecular biologists, biochemists, cell biologists, and clinical oncologists will find this book useful.