Janeway's Immunobiology

by Kenneth M. Murphy, Casey Weaver, Leslie J. Berg

Overview

The definitive text—completely updated and revised

Explore the premier text for immunology at the advanced undergraduate, graduate, and medical school levels. Beginning students appreciate the book’s clear writing and informative illustrations, while advanced students and working immunologists value its comprehensive scope and depth. This edition is thoroughly revised and up to date with significant developments in the field, especially on the topic of innate immunity.

Product Details

ISBN-13:	9780393884890
Publisher:	Norton, W. W. & Company, Inc.
Publication date:	07/01/2022
Edition description:	Tenth Edition
Pages:	960
Product dimensions:	8.60(w) x 10.90(h) x 1.30(d)

About the Author

Kenneth Murphy is the Eugene Opie First Centennial Professor of Pathology and Immunology at Washington University School of Medicine in St. Louis. He received his MD/PhD degree from The Johns Hopkins University School of Medicine. He is a member of the National Academy of Sciences.

Casey Weaver is the Wyatt and Susan Haskell Professor of Medical Excellence in the Department of Pathology at the University of Alabama at Birmingham School of Medicine. He received his MD degree from the University of Florida. His residency and post-doctoral training were completed at Barnes Hospital and Washington University in St. Louis.

Leslie Berg is the chair of the Department of Immunology and Microbiology at University of Colorado Medical School. She served as president of the American Association of Immunologists in 2011–2012 and has received numerous academic awards and honors, including the 2020 American Association of Immunologists Distinguished Fellow Award. She received her PhD at University of California at Berkeley and trained as a postdoctoral fellow at Stanford University School of Medicine.

Table of Contents

Part I: An Introduction to Immunobiology and Innate Immunity
Chapter 1: Basic Concepts in Immunology
Chapter 2: Innate Immunity: The First Lines of Defense
Chapter 3: The Induced Responses of Innate Immunity

Part II: The Recognition of Antigen
Chapter 4: Antigen Recognition by B-cell and T-cell Receptors
Chapter 5: The Generation of Lymphocyte Antigen Receptors
Chapter 6: Antigen Presentation to T Lymphocytes

Part III: The Development of Mature Lymphocyte Receptor Repertoires
Chapter 7: Lymphocyte Receptor Signaling
Chapter 8: The Development and of B and T Lymphocytes

Part IV: The Adaptive Immune Response
Chapter 9: T Cell-Mediated Immunity
Chapter 10: The Humoral Immune Response
Chapter 11: Integrated Dynamics of Innate and Adaptive Immunity
Chapter 12: The Mucosal Immune System

Part V: The Immune System in Health and Disease
Chapter 13: Failures of Host Defense Mechanisms
Chapter 14: Allergy and Allergic Diseases
Chapter 15: Autoimmunity and Transplantation
Chapter 16: Manipulation of the Immune Response

Editorial Reviews

Reviewer: Gudrun F Debes, DVM (Thomas Jefferson University)
Description: This is the ninth edition of a classic in-depth immunology book tailored toward graduate, undergraduate, and medical students. Given its depth and currency of knowledge, it is also suitable for practicing immunologists and advanced trainees, such as postdoctoral fellows. Online resources are available for instructors as well as students and include PowerPoint slides of all figures, movies and animations, exam questions, flashcards, and an online glossary of terms. The previous edition was published in 2011.
Purpose: The aim is to present a comprehensive book written from the host's perspective in the struggle with the microbial world while covering other clinically relevant areas of immunology, such as autoimmunity and immunodeficiencies, allergy, transplant rejection, and cancer immunotherapy. This immunology-centered view contrasts with that of many other books that cover immunology as part of another discipline, such as microbiology or hematology. It is a very useful approach for anybody whose main interest is getting an understanding of immunology. The book provides more details than average immunology books and is useful for acquisition of more in-depth knowledge of the subject. The additional online resources are useful for learning and teaching.
Audience: The book is written for students, and its intended audience is undergraduate students, as well as graduate and medical students, in addition to practicing immunologists. While this is an excellent textbook of immunology for the graduate and postgraduate level and highly interested undergraduate students, it appears to be too detailed for the average undergraduate student. The authors are well-established experts in the field of immunology.
Features: Introductory chapters explain basic concepts and the main players of innate and adaptive immune responses, giving readers a good overview and big picture. The book then goes into great detail about the generation of the adaptive immune response, including details on signaling and development of lymphocytes. Each cell type and component of the adaptive immune response is explained well and extensively illustrated. Once the basis of immunology knowledge is established, the later chapters apply the knowledge to the understanding of immunological processes in the context of disease, such as during infection, allergies, autoimmunity, and immunodeficiencies. Finally, the appendix contains a chapter that explains and illustrates major immunological technique, such as flow cytometry and ELISA, among many others. This chapter is easy to understand and useful for anybody working with these laboratory techniques. In addition, the appendix contains a glossary of terms and CD molecule chart that can be used to look up definitions and unmask CD nomenclature. Some of the best parts of the book are the effective use of color figure illustrations to explain cell types and immunological processes as well the currency of knowledge and depth of the material. These features enable readers to quickly gain in-depth knowledge of immunology or to look up specific areas of immunology as a refresher. There are a few small inconsistencies in terminology between chapters, which is typical for a book like this that is written by many authors.
Assessment: The quality of the book is excellent, and I recommend it to my own students as well as laboratory trainees. It is the most comprehensive textbook of immunology that I am aware of. It is suitable for anybody interested in acquiring in-depth knowledge of immunology or who works in immunology-related fields and would like a reliable compendium. The ninth edition reflects the knowledge gained over the past six years in various areas of immunology, ranging from innate lymphoid cell biology to cancer immunotherapy.

Doody's Review Service