Janeway's Immunobiology / Edition 8

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Overview

Janeway’s Immunobiology is a textbook that introduces the immune system in all its aspects to undergraduates, and also provides a treatment of the subject that is comprehensive enough to be useful to graduate students interested in research, and to medical students focused on clinical applications. The Eighth Edition has been thoroughly revised and updated and is available in both print and e-book formats.

Janeway’s Immunobiology continues to set the standard for currency and authority with its clear writing style and organization, uniform art program, and scientific accuracy. It presents a consistent point of view throughout—that of the host’s interaction with an environment containing many species of potentially harmful microorganisms. The full-color art program is conceptually coherent and illustrates the processes and mechanisms underlying the concepts in the text. The 16 chapters in this readable, accessible textbook are organized and presented in such a way as to help deliver a complete one-semester immunology course, beginning with innate immunity, then moving to adaptive immunity, and ending with applied clinical immunology.

Discussion questions are provided at the end of Chapters 2 to 16. These questions can be used for review, or as the basis for discussion in class or in informal study groups. Summaries conclude each section and each chapter. As in previous editions, a caduceus icon in the margins indicates topics which are correlated to Case Studies in Immunology, Sixth Edition by Geha and Notarangelo.

New in the Eighth Edition

  • Innate immunity has been updated and expanded and is now presented in two separate chapters (Chapters 2 and 3), as well as being further emphasized in the rest of the textbook. Chapter 2 covers antimicrobial peptides and the complement system, and Chapter 3 deals with cellular innate receptors and cell-mediated innate immunity (e.g. TLRs, phagocytosis, NK cells, interferon production, innate-like lymphocytes).
  • The section on complement has been reworked and reconceived—explaining the lectin pathway first—making it easier to teach by placing it into the context of innate recognition.
  • Evolution is now incorporated throughout the text, helping students see similar strategies used by different organisms.
  • The text and figures of Chapter 7 Signaling Through Immune System Receptors have been revised to present a cohesive synthesis of signaling for immunology, focusing on improved illustration of antigen recognition signaling and lymphocyte activation. Signaling through other receptors is dealt with wherever appropriate throughout the book.
  • Updated chapter on B-cell immune responses (Chapter 10), especially on trafficking of B cells in peripheral lymphoid organs (e.g. lymph nodes) and the locations at which they encounter antigen.
  • Coverage of mucosal immunity (Chapter 12) has been brought up to date, including responses to the commensal microbiota and the role of specialized dendritic cells and the regulatory T cells in maintaining tolerance to food antigens and commensal bacteria.
  • Chapter 13, Failures of Host Defense Mechanisms, has been reorganized and revised to structure an understanding of primary immunodeficiencies in the context of developmental pathways.
  • Chapter 16, Manipulation of the Immune Response, has been heavily revised to include a greater emphasis on clinical issues and a complete update of immunotherapeutics and vaccines.
  • Many new and revised figures illustrate the processes and mechanisms underlying the concepts presented in the text.
  • The icons used have been updated and expanded to incorporate a new emphasis on signaling pathways.
  • New references have been added throughout the text.
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Editorial Reviews

Doody's Review Service
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: This is the eighth edition of a well regarded basic textbook for undergraduate and graduate students in immunology that also would be appropriate for medical students, dental students, and those who simply need a reference. The book focuses strongly on the host's interaction with an environment of normal microbes and pathogens. It is. The previous edition was published in 2008.
Purpose: The purpose is to provide a book that is suitable both for students who are taking their first course in immunology and for advanced students. That should be the purpose of any basic textbook and it has been achieved. With the expansion of knowledge about the immune and inflammatory systems, an updated edition is necessary.
Audience: Although the book is written for students, it also could be used by residents and physicians. The author is an authority in the field and has obtained input from a number of well respected immunologists from throughout the world.
Features: The chapter list represents all of the topics that are covered in a general immunology course. Information has been updated throughout the book reflecting expanding knowledge in the discipline. For example, the information on innate immunity has been significantly increased. This is presented in the order in which the immune system responds to infection. Signaling pathways are presented as they appear rather than in one chapter. It will be interesting to discover whether this is more helpful to students than a single chapter describing signaling. Mucosal immunity, which has always been well covered in this book, has been expanded again, reflecting the increasing knowledge that we have of this aspect of the immune system. Each chapter is followed by a series of questions designed, if used properly, to force a student to determine whether information has really been absorbed. There are also references at the end of each chapter, both general as well as section references. The art work is very colorful but also highly stylized. There are four appendixes. The first focuses on brief descriptions of the techniques commonly used by immunologists in the laboratory. The others list CD antigens, cytokines, and their receptors, and chemokines and their receptors. There is also an extensive glossary. In addition, there are online instructor and student resource sites. The instructor site offers the images from the book, animations and videos, and lecture outlines that can be customized. Student resources include the animations and videos, flashcards that can be used to review key terms, and the glossary from the book. Finally, there are ample spaces on most pages for students to add notes.
Assessment: Over the years, this has evolved into a very fine basic textbook. It is well ordered and as complete as possible given that immunology is an ever-changing discipline. There are a few outstanding textbooks on the market and why an instructor chooses one over another is probably primarily a matter of personal taste or perhaps just habit. However, one would not make a mistake choosing this carefully designed book as the primary textbook for a course.
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Product Details

  • ISBN-13: 9780815342434
  • Publisher: Taylor & Francis
  • Publication date: 8/12/2011
  • Edition description: New Edition
  • Edition number: 8
  • Pages: 888
  • Sales rank: 97,872
  • Product dimensions: 8.30 (w) x 10.70 (h) x 1.20 (d)

Table of Contents

Part I: An Introduction to Immunobiology and Innate Immunity
Chapter 1: Basic Concepts in Immunology
Chapter 2: Innate Immunity: The First Lines of Defense
Chapter 3: The Induced Responses of Innate Immunity

Part II: The Recognition of Antigen
Chapter 4: Antigen Recognition by B-cell and T-cell Receptors
Chapter 5: The Generation of Lymphocyte Antigen Receptors
Chapter 6: Antigen Presentation to T Lymphocytes

Part III: The Development of Mature Lymphocyte Receptor Repertoires
Chapter 7: Signaling Through Immune System Receptors
Chapter 8: The Development and Survival of Lymphocytes

Part IV: The Adaptive Immune Response
Chapter 9: T Cell-Mediated Immunity
Chapter 10: The Humoral Immune Response
Chapter 11: Dynamics of Adaptive Immunity
Chapter 12: The Mucosal Immune System

Part V: The Immune System in Health and Disease
Chapter 13: Failures of Host Defense Mechanisms
Chapter 14: Allergy and Allergic Diseases
Chapter 15: Autoimmunity and Transplantation
Chapter 16: Manipulation of the Immune Response

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