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Doody's Review ServiceReviewer: Andrea J. DeLeo, DO, MSE (University of Illinois at Chicago College of Medicine)
Description: This book is focused on intricate neural pathways, the influence of receptor proteins, and basic mechanisms and heritability regarding the epilepsies and epileptogenesis.
Purpose: The editors wish to examine and review neural networks, molecular biology, classifications, and research impacting our knowledge and understanding of the epilepsies. This text is highly detailed in breadth and investigative efforts to elucidate the basic mechanisms underlying epilepsies. The editors masterfully achieve the outlined objectives and goals stated in the preface.
Audience: Although the text is designed primarily for basic science investigators and also targets investigative epileptologists, it is far too dense and detailed for the general neurologist. The information in this text can be applied to the clinical research of epilepsy as well as to the public health burden accompanying this spectrum of neurological disease. However, it falls short on the latter two objectives, as epilepsy's impact on public health in relationship to basic neural science is dealt with in only one of the 70 chapters. The editors are credible and have compiled an outstanding overall text focusing on the intricacies of neural networks involved in epileptogenesis.
Features: The editors offer an expansive review of basic neurochemistry, molecular biology, and review of experimental clinical as well as surgical treatments of epilepsies. Subject matter including basic research of the epilepsies, genetic models in epilepsy and epileptogenesis, gated channels/receptor/and neurotransmitter impact on membrane activity, as well as animal models of neuronal networks in epilepsy are covered. The areas most well covered are animal investigative models of epilepsies and basic neural chemistry and networks (gated channels, molecular cell components, and neural plasticity). The illustrated receptor protein channels and models throughout the text are highly detailed and demonstrate a comprehensive and understandable schema for this rather complex subject; but at times the detail in these highly focused chapters can become somewhat burdensome.
Assessment: This book is truly outstanding, with comprehensive coverage of very complex neural chemistry and its relationship to membrane potentials/neural pathways involved in epileptogenesis. The focus is on investigative models more than treatments and basic background information regarding the epilepsies, in contrast to Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, 4th edition, by Niedermeyer and Da Silva (Lippincott Williams and Wilkins, 1999). I do feel this book is useful to the epileptologist and investigative researcher.