Jasper's Basic Mechanisms of the Epilepsies

Overview

This volume in the Advances in Neurology Series is the third edition of a classic work in epilepsy research. By bringing together the most significant current research findings from all relevant basic science and clinical disciplines, this hands-on resource helps you effectively bridge the gap between neuroscience and neurology. Ideal for the practicing neurologist, neuroscience researcher, or neurosurgeon, this comprehensive review offers the informed perspectives you need to ...
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Overview

This volume in the Advances in Neurology Series is the third edition of a classic work in epilepsy research. By bringing together the most significant current research findings from all relevant basic science and clinical disciplines, this hands-on resource helps you effectively bridge the gap between neuroscience and neurology. Ideal for the practicing neurologist, neuroscience researcher, or neurosurgeon, this comprehensive review offers the informed perspectives you need to unravel the mysteries of epilepsy management.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Andrea J. DeLeo, DO, MSE (University of Illinois at Chicago College of Medicine)
Description: This book is focused on intricate neural pathways, the influence of receptor proteins, and basic mechanisms and heritability regarding the epilepsies and epileptogenesis.
Purpose: The editors wish to examine and review neural networks, molecular biology, classifications, and research impacting our knowledge and understanding of the epilepsies. This text is highly detailed in breadth and investigative efforts to elucidate the basic mechanisms underlying epilepsies. The editors masterfully achieve the outlined objectives and goals stated in the preface.
Audience: Although the text is designed primarily for basic science investigators and also targets investigative epileptologists, it is far too dense and detailed for the general neurologist. The information in this text can be applied to the clinical research of epilepsy as well as to the public health burden accompanying this spectrum of neurological disease. However, it falls short on the latter two objectives, as epilepsy's impact on public health in relationship to basic neural science is dealt with in only one of the 70 chapters. The editors are credible and have compiled an outstanding overall text focusing on the intricacies of neural networks involved in epileptogenesis.
Features: The editors offer an expansive review of basic neurochemistry, molecular biology, and review of experimental clinical as well as surgical treatments of epilepsies. Subject matter including basic research of the epilepsies, genetic models in epilepsy and epileptogenesis, gated channels/receptor/and neurotransmitter impact on membrane activity, as well as animal models of neuronal networks in epilepsy are covered. The areas most well covered are animal investigative models of epilepsies and basic neural chemistry and networks (gated channels, molecular cell components, and neural plasticity). The illustrated receptor protein channels and models throughout the text are highly detailed and demonstrate a comprehensive and understandable schema for this rather complex subject; but at times the detail in these highly focused chapters can become somewhat burdensome.
Assessment: This book is truly outstanding, with comprehensive coverage of very complex neural chemistry and its relationship to membrane potentials/neural pathways involved in epileptogenesis. The focus is on investigative models more than treatments and basic background information regarding the epilepsies, in contrast to Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, 4th edition, by Niedermeyer and Da Silva (Lippincott Williams and Wilkins, 1999). I do feel this book is useful to the epileptologist and investigative researcher.
Andrea J. DeLeo
This book is focused on intricate neural pathways, the influence of receptor proteins, and basic mechanisms and heritability regarding the epilepsies and epileptogenesis. The editors wish to examine and review neural networks, molecular biology, classifications, and research impacting our knowledge and understanding of the epilepsies. This text is highly detailed in breadth and investigative efforts to elucidate the basic mechanisms underlying epilepsies. The editors masterfully achieve the outlined objectives and goals stated in the preface. Although the text is designed primarily for basic science investigators and also targets investigative epileptologists, it is far too dense and detailed for the general neurologist. The information in this text can be applied to the clinical research of epilepsy as well as to the public health burden accompanying this spectrum of neurological disease. However, it falls short on the latter two objectives, as epilepsy's impact on public health in relationship to basic neural science is dealt with in only one of the 70 chapters. The editors are credible and have compiled an outstanding overall text focusing on the intricacies of neural networks involved in epileptogenesis. The editors offer an expansive review of basic neurochemistry, molecular biology, and review of experimental clinical as well as surgical treatments of epilepsies. Subject matter including basic research of the epilepsies, genetic models in epilepsy and epileptogenesis, gated channels/receptor/and neurotransmitter impact on membrane activity, as well as animal models of neuronal networks in epilepsy are covered. The areas most well covered are animal investigative models ofepilepsies and basic neural chemistry and networks (gated channels, molecular cell components, and neural plasticity). The illustrated receptor protein channels and models throughout the text are highly detailed and demonstrate a comprehensive and understandable schema for this rather complex subject; but at times the detail in these highly focused chapters can become somewhat burdensome. This book is truly outstanding, with comprehensive coverage of very complex neural chemistry and its relationship to membrane potentials/neural pathways involved in epileptogenesis. The focus is on investigative models more than treatments and basic background information regarding the epilepsies, in contrast to Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, 4th edition, by Niedermeyer and Da Silva (Lippincott Williams and Wilkins, 1999). I do feel this book is useful to the epileptologist and investigative researcher.

4 Stars! from Doody
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Product Details

Table of Contents

Contributing Authors
Foreword
Preface
Acknowledgments
Sect. I Introduction: The Provinces of the Epilepsies for Basic Research
1 New Waves of Research in the Epilepsies: Crossing into the Third Millennium 3
2 Genetic Heterogeneity and Epidemiology of the Epilepsies 59
Sect. II Neural Development, Genes, and the Epilepsies
Section II Introduction 75
3 Homeobox Genes in Development 81
4 Cortical Dysplasias, Genetics, and Epileptogenesis 95
5 The Relevance of Slight Migrational Disturbances (Microdysgenesis) to the Etiology of the Epilepsies 123
6 The Role of Neural Activity in Synaptic Development and Its Implications for Adult Brain Function 133
7 Ontogeny of Channels, Transmitters, and Epileptogenesis 145
8 Age-Dependent Vulnerability to Seizures 161
9 Nicotinic Receptor: A Prototype of Allosteric Ligand-Gated Ion Channels and Its Possible Implications in Epilepsy 171
10 GABA is the Principal Fast Acting Excitatory Transmitter in the Neonatal Brain 189
11 Developmental Neuroplasticity: Roles in Early Life Seizures and Chronic Epilepsy 203
Sect. III The Idiopathic Epilepsies
Section III Introduction 219
12 Single-Gene Models of Epilepsy 227
13 Studies of the Lethargic (lh/lh) Mouse Model of Absence Seizures: Regulatory Mechanisms and Identification of the lh Gene 239
Pt. 1 GABA Receptors in the lh/lh Mouse Model of Absence Seizures 240
Pt. 2 Positional Cloning of the lh Absence Disease Gene 247
14 Absence Epilepsy: Advances in Experimental Animal Models 253
15 Experimental Models of Multifactorial Epilepsies: The EL Mouse and Mice Susceptible to Audiogenic Seizures 279
16 Transgenic Approaches to Epilepsy 291
17 Intrinsic Properties of Reticular Thalamic Neurons Relevant to Genetically Determined Spike-Wave Generation 297
18 Neuronal Networks in the Genetically Epilepsy-Prone Rat 311
19 Genetic Epidemiology and the Search for Epilepsy Genes 323
20 Genes for Rare Idiopathic Generalized Epilepsies: BFNC 341
21 Mapping and Positional Cloning of Common Idiopathic Generalized Epilepsies: Juvenile Myoclonus Epilepsy and Childhood Absence Epilepsy 351
22 Genes of Partial Epilepsies 375
23 The Molecular Genetic Basis of the Progressive Myoclonus Epilepsies 383
24 Dentatorubral-Pallidoluysian Atrophy (DRPLA): Clinical Features and Molecular Genetics 399
25 Mitochondrial Genes for Generalized Epilepsies 411
26 Parental Imprinting and Angelman Syndrome 421
Sect. IV Symptomatic Lesional Epilepsies
Overview Introduction 433
IV-A Neuronal channels, receptors and transporters: Molecular structure, gating, and pharmacology
Section IV-A Introduction 437
27 Molecular Properties of Brain Sodium Channels: An Important Target for Anticonvulsant Drugs 441
28 Chemical Modulation of Sodium Channels and GABA[subscript A] Receptor Channel 457
29 Voltage-Dependent Activation of Ion Channels 481
30 Membrane Properties and Epilepsy 493
31 GABA Receptor Function and Epilepsy 499
32 Ligand-gated Channel: Postsynaptic Receptors and Drug Targets 511
33 Glutamate Receptor Channels: A Possible Link between RNA Editing in the Brain and Epilepsy 525
34 Antibodies to Glutamate Receptors: A Role in Excitatory Dysregulation of the Central Nervous System 535
35 Evidence for Glutamate Receptor Autoimmunity in Pathogenesis of Rasmussen's Encephalitis 543
36 GABA and Glutamate Transporters: Therapeutic and Etiological Implications for Epilepsy 551
IV-B Glia and Epilepsy
Section IV-B Introduction 561
37 Physiology of Glial Cells 565
38 Modulation of Neuronal Excitability by Astrocytes 573
39 Contribution of Astrocytes to Seizure Activity 583
40 The Molecular Neuron-Glia Couple and Epileptogenesis 591
IV-C Initiation, Synchronization, and Spread of Epileptic Discharges
Section IV-C Introduction 603
41 Mechanisms of Epileptogenesis 607
42 Synaptic Plasticity in Kindling 631
43 Presynaptic and Postsynaptic Mechanisms of Long-Term Potentiation 645
44 Second Messengers, Long-Term Potentiation, Gene Expression, and Epileptogenesis 659
45 Epileptogenic Neurons and Circuits 665
46 Role of Metabotropic Glutamate Receptors in Epilepsy 685
47 Mechanisms of Neuronal Synchronization During Epileptiform Activity 699
48 Functionally Relevant and Functionally Disruptive (Epileptic) Synchronized Oscillations in Brain Slices 709
49 Basic Mechanisms of Status Epilepticus 725
IV-D Epileptic Cell Damage and Epileptogenesis
Section IV-D Introduction 735
50 Neurocytology of a Primate Model of Human Temporal Lobe Epilepsy 737
51 Neuronal Loss and Synaptic Reorganization in Temporal Lobe Epilepsy 743
52 Synaptic Reorganizations in Human and Rat Hippocampal Epilepsy 763
53 Physiological and Anatomical Correlates of the Human Dentate Gyrus: Consequences or Causes of Epilepsy 781
54 Excitability Changes in Epileptic Human Dentate Gyrus and Temporal Neocortex 795
55 The Role of Nonprincipal Cells in Dentate Gyrus Excitability and its Relevance to Animal Models of Epilepsy and Temporal Lobe Epilepsy 805
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