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Journey from Cognition to Brain to Gene: Perspectives from Williams Syndrome

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A blueprint for the investigation of neurodevelopmental disorders, this book presents the work of a team of scientists using a multidisciplinary, integrated approach to link genes with human behavior. Using Williams syndrome as a model,leading researchers in neuroanatomy, neurocognition, neurophysiology, and molecular genetics have built bridges between disciplines to link higher cognitive functions,their underlying neurobiological bases, and their molecular genetic ...

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Overview

A blueprint for the investigation of neurodevelopmental disorders, this book presents the work of a team of scientists using a multidisciplinary, integrated approach to link genes with human behavior. Using Williams syndrome as a model,leading researchers in neuroanatomy, neurocognition, neurophysiology, and molecular genetics have built bridges between disciplines to link higher cognitive functions,their underlying neurobiological bases, and their molecular genetic underpinnings.

One of the book's many strengths is that the scientists from each discipline studied the same individuals with Williams syndrome. As the book shows, Williams syndrome is a fascinating disorder because of the "peaks and valleys" among cognitive domains: severe intellectual deficits but remarkably spared and effusive language; specific impairment in spatial construction but great strength in face processing and sociability. By capitalizing on these dissociations in higher cognitive functioning,the book provides a model for the study of brain-behavior relationships as well as for the mapping of brain and behavior phenotypes to the genome and beyond.

Contributors: Ralph Adolphs, Twyla Alvarez, Lawrence Appelbaum, Ursula Bellugi, Dennis Burian, Xiao-Ning Chen, Michael Chiles, Stephan Eliez, Albert Galaburda, Hanao Hirota, Wendy Jones, Julie Korenberg, Zona Lai, Liz Lichtenberger, Alan Lincoln, Rumiko Matsuoka, Debra Mills, Helen Neville, Judy Reilly, Allan Reiss, Bruce Roe, Marie St. George, J. Eric Schmidtt, Erica Straus.

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Product Details

  • ISBN-13: 9780262523127
  • Publisher: MIT Press
  • Publication date: 11/1/2001
  • Series: Bradford Books Series
  • Edition description: New Edition
  • Pages: 150
  • Product dimensions: 7.00 (w) x 9.00 (h) x 0.50 (d)

Meet the Author

Ursula Bellugi is Professor and Director of the Laboratory for Cognitive Neurosciences at the Salk Institute for Biological Studies. She is the coauthor of What the Hands Reveal about the Brain (MIT Press, 1990).

Marie St. George is a Scientist at the Center for Research in Language at the University of California, San Diego.

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Table of Contents

Contributors
Preface
1 The Neurocognitive Profile of Williams Syndrome: A Complex Pattern of Strengths and Weaknesses 1
2 Hypersociability: The Social and Affective Phenotype of Williams Syndrome 43
3 Neurophysiological Markers of Face Processing in Williams Syndrome 73
4 Neuroanatomy of Williams Syndrome: A High-Resolution MRI Study 105
5 Cellular and Molecular Cortical Neuroanatomy in Williams Syndrome 123
6 Genome Structure and Cognitive Map of Williams Syndrome 147
Epilogue 179
Editors and Authors 185
Index 187
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