Kindling 5


Proceedings of the Fifth International Conference held in Victoria, Canada, June 27-30 1996

The book contains black-and-white illustrations.

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Proceedings of the Fifth International Conference held in Victoria, Canada, June 27-30 1996

The book contains black-and-white illustrations.

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Editorial Reviews

These proceedings of the Fifth International Conference on Kindling held in June, 1996 in Victoria, British Columbia address new research on the molecular biological, anatomical, and physiological substrates of kindling, as well as in the age- dependent effects and complex behavioral consequences of kindling, its sensitivity to drugs, and its relevance to the clinical epilepsies. Contributions are divided into seven sections on developmental patterns; electrophysiological mechanisms; morphological and anatomical mechanisms; synaptic pharmacology and neurochemistry of kindling; behavioral effects of kindling; drugs; and clinical implications. Includes a generous number of good quality b&w illustrations. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780306458057
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 2/28/1998
  • Series: Advances in Behavioral Biology Series, #48
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 536

Table of Contents

1 Genetic Predisposition and Kindling Susceptibility in Primates 1
2 Idiosyncrasies of Limbic Kindling in Developing Rats 15
3 Long-Term Effects of Kindling on Learning and Memory in the Developing Brain 27
4 Short Interval Electrical Amygdala Kindling in Infant Rats: The Paradigm and Its Application to the Study of Age-Specific Convulsants 35
5 Ontogeny of Temporal Lobe Epilepsy in Amygdala-Kindled Kittens: Phenomenology, Treatment Alternatives, and Basic Mechanisms of Sleep-Waking State Seizure Activity 45
6 Lasting Prolongation of NMDA Channel Openings after Kindling 65
7 Long-Lasting Changes in the Pharmacology and Electrophysiology of Amino Acid Receptors in Amygdala Kindled Neurons 75
8 Role of the Dentate Gyrus in the Spread of Seizures within the Hippocampal-Parahippocampal Circuit 89
9 Quenching: Persistent Alterations in Seizure and Afterdischarge Threshold following Low-Frequency Stimulation 101
10 Kindling-like Effects of Electroconvulsive Shock Seizures 121
11 The Role of Rhinencephalic Networks in Early Stage Kindling 133
12 The Role of Rhinencephalic Networks in the Late Stages of Kindling 151
13 The Perirhinal Cortex and Kindled Motor Seizures 167
14 Comparison of Synapse Remodeling following Hippocampal Kindling and Long-Term Potentiation 179
15 Neuronal Growth and Neuronal Loss in Kindling Epileptogenesis 193
16 Dissociations between Kindling and Mossy Fiber Sprouting 211
17 Regional Specific Changes in Glutamate and Gaba[subscript A] Receptors, PKC Isozymes, and Ionic Channels in Kindling Epileptogenesis of the Hippocampus of the Rat 229
18 Kindling: A Pathologic Activity-Driven Structural and Functional Plasticity in Mature Brain 245
19 Activities of Protein Kinase C in the Kindling Model of Epilepsy 255
20 Kindling Induces Long-Term Changes in Gene Expression 267
21 Kindling in Genetically Altered Mice: Implications for the Role of LTP in Kindling 285
22 Neurotrophins and Kindling Epileptogenesis 299
23 Somatostatin- and Neuropeptide Y-Mediated Neurotransmission in Kindling Epileptogenesis 313
24 Amygdala Kindling and Rodent Anxiety 327
25 Long-Term Amygdala Kindling and Defensive Behavior in Rats 349
26 The Neurobehavioral Consequences of Kindling 361
27 Kindling and Spatial Cognition 377
28 Long-Lasting Behavioral and Electrophysiological Effects Induced by Partial Hippocampal Kindling 395
29 Protective Effects of Brain-Derived Neurotrophic Factor in Hippocampal Kindling 409
30 Perforant Path Kindling, NMDA Antagonism, and Late Paired Pulse Depression 421
31 Pharmacology of Glutamate Receptor Antagonists in the Kindling Model 435
32 Interactions between Convulsants at Low-Dose and Phenobarbital in the Hippocampal Slice Preparation 451
33 The Syndrome of Mesial Temporal Lobe Epilepsy: A Role for Kindling 469
34 Contributions of Kindling to Clinical Epileptology 485
35 Vagus Nerve Stimulation: Effects on Circadian Sleep Organization and Kindling Development in the Cat 495
36 Facilitation of Kindling and Long Term Potentiation by Hippocampal Lesions 501
Summary Discussion 509
Participants Photo 511
Index 513
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