Lab-on-Chips for Cellomics: Micro and Nanotechnologies for Life Science / Edition 1

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The convergence of life sciences and micro/nanotechnologies is one of fastest growing modern R&D areas with an enormous potential societal impact. Microfluidics or Lab-on-Chip (LOC) devices, also dubbed BioMEMS, are a fascinating example of this combination of two scientific areas. This book, which is the first volume entirely dedicated to microfabricated cell-based systems, will provide readers with a quick introduction to the field as well as with a variety of specific examples of such Lab-on-Chip systems for cellomics applications. It will give investigators inspiration for innovative research topics, whereas end users will be surprised about the wide variety of new and exciting applications.
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Editorial Reviews

From the Publisher

From the reviews:

"This is a very timely book on many of the applications of microfluidic chips for cell related experiments. On 360 pages, a series of world renown authors in the 'lab on chip' area disclose some of their most exciting work, give us their opinion and overview of the most rapidly growing application of microfluidics.

The contents is organized in chapters for microfluidic devoices, pretreatment of cell samples, liposome model systems, electric field cell manipulation, electroporation, patch clamp, mechanical measurements on cells, apoptosis, cell cultivation, embryonic stem cell work, single cell experiments, organelle analysis and tissue formation. The book is easy reading for both, engineers and (probably) biologists, with many b/w graphs and photos. There are even a few color plates at the end of the book. Each chapter comes with up-to-date references taken from the scientific literature.

Even though I do not subscribe to terms like 'cellomics' or 'lab on chips,' which I believe are of no scientific value, I actually like the book! The many different authors guarantee a maximum in detail knowledge and expertise, however, the book represents rather a collection of short stories than a comprehensive overview. I also wonder if any biologists were consulted in the process. I suspect the majority of authors are from the engineering sector. I would appreciate a chapter or two on basic microfab, scaling laws related to cell biology and fundamentals of cell biology methods.

Overall, I can recommend this book to any researcher in the 'lab on chip' area, and to curious engineers and scientists in the fields of biology, medicine, chemistry and physics." (Andreas Manz, London, February 6, 2005)

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Product Details

  • ISBN-13: 9781402028601
  • Publisher: Springer Netherlands
  • Publication date: 12/21/2004
  • Edition description: 2004
  • Edition number: 1
  • Pages: 364
  • Product dimensions: 6.43 (w) x 9.75 (h) x 0.92 (d)

Table of Contents

1: Microfluidic devices for cellomics; H. Andersson and A. van den Berg

2: Pretreatment of biological samples for microchip analysis; J. Ferrance, J. Landers

3: Liposomes as cellular model systems; L Locascio, W. Vreeland, A. Jahn, and M. Gaitan

4: A versatile chip-based tool for the controlled manipulation of microparticles in biology using high frequency electromagnetic fields; C. Duschl, P. Geggier, M. Jäger, M. Stelzle, T. Müller, T. Schnelle, G. Fuhr

5: Microelectroporation in cellomics; B. Rubinsky

6: Patch clamp microsystems; T. Lehnert and M. Gijs

7: Using lab-on-a-chip technologies to understand cellular mechanotransduction; D. Pirone and C. Chen

8: Analysis of apoptosis on chip; F. Wolbers, C. Haanen, H. Andersson, A. van den Berg and I. Vermes

9: On chip single cell cultivation systems; K. Yasuda

10: Human embryonic stem cells and microfluidics; V. Abhyankar and D. Beebe

11: Cellular and subcellular analysis on chip; H. Lu, K. Jensen

12: Microfluidic cell culture devices; Y. Sakai, E. Leclerc , and T. Fujii

13: Micromachined bioreactor for in vitro cell self-assembly and 3D tissue formation; K. Domansky, A. Sivaraman and L. Griffith

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