Laboratory Hematology Practiceby Kandice Kottke-Marchant
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Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.
Description: This is a comprehensive book on laboratory diagnosis of hematological disease using new hematology testing methods. It is sponsored by the International Society for Laboratory Hematology (ISLH); ISLH is recognized for promoting technology and standardization in laboratory hematology.
Purpose: The purpose is to provide "a practical approach to understanding the diagnostic utility of new hematology laboratory testing," critical assessment of new technology, and guidance on implementation, interpretation, and managing new technology. These worthy objectives are somewhat met by the authors.
Audience: The book is intended for those involved in diagnosis of hematological diseases using laboratory methods pathologists or clinical hematologists, clinical laboratory scientists (in training or in practice), residents, or fellows. It also would be useful to anyone interested in contemporary hematology laboratory technology and how results are used in clinical diagnosis and management. The authors are well recognized for their expertise in laboratory hematology.
Features: This 748-page book covers many subjects typically not grouped in a single book. The 55 chapters are divided into eight major sections, covering cellular analysis, flow cytometry, molecular diagnostics, bone marrow analysis, hemostasis and thrombosis, special hematology techniques, point of care testing, and information management. Subjects vary from esoteric theory to very practical applications. For example, Chapter 12 ("a new paradigm for cytometric analysis") uses Bach's "Jesu, Joy of Man's Desiring" as an analogy for paradigm changes, illustrated by parametric plots I did not understand this chapter at all. Meanwhile, the chapter on digital imaging nicely recapitulates the history of this area and covers all relevant issues (quality assurance, proficiency testing, information systems, and file requirements, etc.). I was disappointed in the uneven color quality of the photomicrographs (for example, the cytoplasmic detail of a 'faggot' cell (figure 2.9) is poor). Other photomicrographs are too dark, the background is yellow, or imperfect Kohler illumination is obvious. Yet, others are spot on. This book is intended to help laboratorians "critically understand, assess, implement and manage a wide variety of hematology technologies," but the chapter on von Willebrand disease had no mention of the impact of blood group (ABO) on vWF activity or antigen measurements, or the potential overdiagnosis in people with type O and underdiagnosis in those with type AB. Table 34.1 includes a ratio of ristocetin cofactor:vWF antigen of 0.7 as a diagnostic threshold, below which type 2A or 2B von Willebrand disease should be considered. Yet there is no discussion of ethnic differences which render this metric useless (i.e., natural vWF variant in healthy African Americans without bleeding histories, resulting in impaired ristocetin binding and yielding disproportionately low vWF ristocetin cofactor activity:vWF antigen ratio which would qualify for a von Willebrand disease type 2A or 2B diagnosis).
Assessment: This is an interesting book for those with a primary interest in laboratory hematology.
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Meet the Author
Dr Kandice Kottke-Marchant, MD PhD, Section Head, Hemostasis and Thrombosis, Department of Clinical Pathology, The Cleveland Clinic Foundation, Cleveland, Ohio, USA and President, International Society of Laboratory Hematology. She is also a Professor of Pathology at the Cleveland Clinic Lerner College of Medicine and an Adjunct Professor of Biomedical Engineering at Case Western Reserve University. She has published over 100 peer-reviewed publications in the field of haemostasis, is an international expert on platelet testing and aspirin resistance, and has served on review panels from the National Institutes of Health (NIH), College of American Pathologists (CAP), ISO/TC212 and North American Specialized Coagulation Laboratory Association (NASCOLA). She has been a driving force to increase the international visibility and impact of the ISLH. She has been responsible for running the ISLH annual Symposia since 2002. Due to her involvement in haemostasis and the ISLH, Dr. Kottke-Marchant will be uniquely positioned to serve as one of the co-Editors of the Textbook of Laboratory Hematology.
Elkin Simson, MD, PCAP, FACSP is the Medical Director of the Center for Clinical Laboratories and Hematology Laboratory at the Mount Sinai Hospital. He is also Associate Professor and Vice Chairman of the Department of Pathology at the Mount Sinai School of Medicine, New York, NY, USA. Dr. Simson was formerly the Vice-President for Medical and Scientific Affairs at Technicon Instruments Corporation, where he participated in the development of the first automated haematology analyzers to combine the CBC and WBC differential into a single instrument. Dr Simson is the Past President of the ISLH and is Vice-President of the International Council for Standardization in Hematology (ICSH). He has been Chairman of the Hematology Area Committee of NCCLS (now CLSI), a member of Council of the National Reference System for the Clinical Laboratory (NRSCL) and the Hematology and Quality Improvement Subcommittees of the NCCCLS. He was a member of the Hematology and Pathology Advisory Panel of the Food and Drug Administration (FDA). Due to his long-time involvement in haematology automation and standards organizations, Dr. Simson is an idea co-editor.
The proposed section editors are chosen from international experts in their respective fields; most have also been long-time ISLH members who have been faculty at one or more ISLH Symposia and who have been repeatedly recognized as outstanding speakers and contributors by the participants. Dr Bruce Davis is one of the co-founders of the ISLH and has a long history of involvement in developing automated cellular and flow cytometric technologies. Professor Alberto Orfao from Spain is one of the world’s foremost experts on flow cytometry. Professor Samuel Machin is currently President of the British Society of Haematology and is an international authority on haemostasis testing. Stefanie McFadden is a medical technologist who is sought after as a consultant for laboratory management and informatics issues.
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