Laboratory Medicine: The Diagnosis of Disease in the Clinical Laboratory / Edition 1

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A complete full-color guide to selecting the correct laboratory test and interpreting the results –- covering the entire field of clinical pathology

A Doody's Core Title ESSENTIAL PURCHASE for 2011!

"The editor and authors are well respected in their fields of expertise - this is an all-star cast....This book nicely fills the gap between comprehensive clinical laboratory science texts and the traditional and well-recognized, definitive laboratory medicine texts....It would be perfect for medical students and practicing physicians and it would be a perfect companion textbook for those teaching laboratory medicine in a medical school curriculum. 3 Stars."—Doody's Review Service

Laboratory Medicine is the most comprehensive, user-friendly, and well-illustrated guide available for learning how to order the correct laboratory test and understand the clinical significance of the results. The book features an easy-to-follow, consistent presentation for each disease discussed. Chapters begin with a brief description of the disorder followed by a discussion that includes tables detailing the laboratory evaluation of specific disorders, diagnosis, baseline tests to exclude diagnostic possibilities, and clinical indications that warrant further screening and special testing.

With new, increasingly expensive and complicated tests appearing almost daily, Laboratory Medicine is required reading for students and physicians who want to keep abreast of the latest testing procedures and maximize accuracy and patient safety.


  • 36 clinical laboratory methods presented in easy-to-understand illustrations that include information on the expense and complexity of the assays
  • More than 200 tables and full-color algorithms that encapsulate important information and facilitate understanding
  • Full-color blood-smear micrographs that demonstrate common abnormal morphologies of red blood cells
  • Valuable learning aids in each chapter, including learning objectives, chapter outlines, and a general introduction
  • Logical systems-based organization that complements most textbooks
  • 13-page table of Clinical Laboratory Reference Values that show the conversions between U.S. and SI units for each value

Coverage that spans ALL of clinical pathology:

Concepts in Laboratory Medicine; Methods, Autoimmune Disorders Involving the Connective Tissue and Immunodeficiency Diseases; Histocompatibility Testing and Transplantation; Infectious Diseases; Toxicology, Diseases of Infancy and Childhood; Blood Vessels; The Heart; Diseases of Red Blood Cells; Bleeding and Thrombotic Disorders; Transfusion Medicine; Diseases of White Blood Cells, Lymph Nodes, and Spleen; The Respiratory System; The Gastrointestinal Tract; The Liver and Biliary Tract; Pancreatic Disorders; The Kidney; Male Genital Tract; Female Genital System; Breast; The Endocrine System.

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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This broad overview of laboratory medicine is true to its subtitle, "The Diagnosis of Disease in the Clinical Laboratory."
Purpose: The purpose is to provide a comprehensive guide to the appropriate use of clinical laboratory testing for diagnosis, treatment, and management of disease.
Audience: It is intended for medical students, but the information is sufficiently detailed and complex to be of use for laboratory medicine or pathology residents early in their training. It also would be useful for physicians in practice who may want to update their knowledge on testing related to different medical specialties (e.g., rheumatology, hematology, etc.). The editor and authors are well respected in their fields of expertise - this is an all-star cast.
Features: This looks like an evolution of the author's Laboratory Medicine: Clinical Pathology in the Practice of Medicine (American Society for Clinical Pathology Press, 2002). Indeed, the first chapter of this book, which describes test methodologies, has the identical set of wonderfully self-explanatory pictures/graphics as the previous one. However, although the chapter titles mirror those in his previous book, this time the author has brought together a world-class group of specialty field experts as chapter authors instead of writing the entire book himself; this version is much improved from the previous one. Some of the chapters (e.g., infectious diseases) are sufficiently comprehensive to stand alone as references in their own right. The division of material into organ-system based chapters is at times awkward — for example, I would not normally go to a section titled "female genital tract" to read about pregnancy-related conditions. (There are entire books devoted to pregnancy and laboratory medicine issues.) One very minor issue — the peripheral blood smear photomicrographs in the section on diseases of red blood cells have an unnatural blue tinge. And one very minor quibble — some very straightforward statements do not adequately reflect the underlying scientific complexities (e.g., "a low value for von Willebrand factor-cleaving protease activity is the diagnostic hallmark for TTP" is contrary to evidence published in Blood 2010;115(8):1500-15). Admittedly, these nuances may be splitting hairs too fine for a medical student audience. However, while this book is intended for medical students, the breadth and depth of information it contains is much above that normally expected to be mastered by second-year medical students.
Assessment: This book nicely fills the gap between comprehensive clinical laboratory science texts and the traditional and well-recognized, definitive laboratory medicine texts (Henry's Clinical Diagnosis and Management by Laboratory Methods, 21st edition, McPherson and Pincus (Elsevier, 2007); Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 4th edition, Burtis et al. (Elsevier, 2006); Clinical Laboratory Medicine, 2nd edition, McClatchey et al. (Lippincott Williams & Wilkins, 2002)). It would be perfect for medical students and practicing physicians and it would be a perfect companion textbook for those teaching laboratory medicine in a medical school curriculum.
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Product Details

  • ISBN-13: 9780071626743
  • Publisher: McGraw-Hill Professional Publishing
  • Publication date: 5/10/2010
  • Series: LANGE Basic Science Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 600
  • Sales rank: 626,721
  • Product dimensions: 8.50 (w) x 10.80 (h) x 0.90 (d)

Meet the Author

Michael Laposata, MD, PhD

Edward and Nancy Fody Professor and

Executive Vice Chair of Pathology


Vanderbilt University Hospital

Professor of Medicine

Vanderbilt University School of Medicine

Nashville, TN

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Table of Contents

Clinical Laboratory Reference Values
1. Concepts in Laboratory Medicine, Michael Laposata
2. Methods, Michael Laposata
3. Autoimmune Disorders Involving the Connective Tissue and Immunodeficiency Diseases, Mandakolathur R. Murali
4. Histocompatibility Testing and Transplantation, Yash Pal Agrawal and Susan L. Saidman
5. Infectious Diseases, Eric D. Spitzer
6. Toxicology, Sheila Dawling and Michael Laposata
7. Diseases of Infancy and Childhood, Paul Steele
8. Blood Vessels, Michael Laposata
9. The Heart, Fred S. Apple
10. Diseases of Red Blood Cells, Daniel D. Mais
12. Bleeding and Thrombotic Disorders, Elizabeth M. Van Cott and Michael Laaposata
12. Transfusion Medicine, Christopher P. Stowell and Jacqueline J. Haas
13. Diseases of White Blood Cells, Lymph Nodes, and Spleen
14. The Respiratory System, Alison Woodworth
15. The Gastrointestinal Tract, D. Robert Dufour
16. The Liver and Biliary Tract, William E. Winter
17. Pancreatic Disorders, Fritz F. Parl and Michael Laposata
18. The Kidney, William E. Winter
19. Male Genital Tract, D. Robert Dufour
20. Female Genital Tract, Stacy E.F. Melanson
21. Breast, Karin E. Finberg
22. The Endocrine System, Michael Laposata, Samir L. Aleryani, and Alison Woodworth

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