Late Effects of Childhood Cancerby Daniel Green, Hamish Wallace
The treatment of childhood cancer has become increasingly successful over the last forty years, and during the last two decades in particular, and the overall cure rate is now 60-70%. This, in turn, has introduced new issues for the clinician as the number of long-term survivors has increased. Some of the therapies that have contributed most to the improvement in… See more details below
The treatment of childhood cancer has become increasingly successful over the last forty years, and during the last two decades in particular, and the overall cure rate is now 60-70%. This, in turn, has introduced new issues for the clinician as the number of long-term survivors has increased. Some of the therapies that have contributed most to the improvement in survival are now known to have serious consequences for the patient in later life, and many survivors will be affected by physical, educational and psychological disability to a lesser or greater degree.
This definitive reference brings together all aspects of long-term effects of treatment for cancer during childhood in a single comprehensive volume. International in perspective, the book is structured according to complication rather than original site of malignancy for ease of reference. Topics covered include problems in the neurological system and special senses of sight and sound, cardiovascular, respiratory, gastrointestinal, urological and musculoskeletal complications, effects on the endocrine system and, in particular, future fertility, and secondary cancers. The book also reviews in detail the important issues of quality of life, prevention initiatives and strategies for long-term follow up. Key point summaries are included throughout, and the references are annotated to guide the reader quickly to seminal primary papers and key review articles.
With an accessible and consistent approach throughout, Late Effects of Childhood Cancer is an invaluable source of information and guidance for pediatric oncologists, who need to keep fully informed in order to advise patients and their parents appropriately, and also for pediatric and adult endocrinologists, adult oncologists and other physicians to whom the patient with late effects may initially present.
Description: This is a "working text" designed to be informative and promote active use of the book in the clinic as well as in "collaborative ventures" with others caring for long term survivors of childhood cancer. It is organized by physiologic systems, identifying the potential late effects that could affect long-term survivors. The references are complete with key primary papers and major review articles indicated as such for the benefit of the user.
Purpose: The editors have successfully achieved their goal of providing a summary of current knowledge regarding late effects of childhood cancer. Whether their stated larger goal for this book to promote multicenter studies of interventions to "prevent, treat or modify late effects" in this patient population is achieved will require the test of time and the citation record for this book. The authors of individual chapters impartially indicate where a void of data prevents establishing conclusions. They also identify areas of controversy and need for further study. In addition, that the changing design of treatment protocols will require altered expectations of late effects is underscored in discussions of the fate of future survivors.
Audience: This book is most appropriate for physicians, nurses, social workers, and psychologists providing comprehensive care and assessment of long-term survivors of childhood cancer.
Features: Physicians in training are brought quickly to the significant issues faced by the survivors survivors of treatments recently or long out of use that the trainee is unfamiliar with. A "modular e-text" of the chapters in this book would facilitate reproduction of the chapters and thereby education of the endocrinologists, urologists, cardiologists, and other specialists providing consultation to the long-term survivor population. Promulgation of these individual chapters could enhance the "collaborative ventures" sought for these patients. Useful "Key Points" provide a succinct summary at the end of each chapter highlighting the major facts and remaining questions.
Assessment: This is a timely addition to the field of pediatric oncology as the biopsychosocial impact of survivorship and follow-up of the long term survivors has gained increasing recognition. It provides a comprehensive update to Survivors of Childhood Cancer: Assessment and Management, Schwartz et al. (Mosby, 1994), for those providing care to long-term survivors of childhood cancer. Childhood Cancer Survivors: A Practical Guide to Your Future, by Keene et al. (O'Reilly and Associates, 2000), is directed to childhood cancer survivors and their need as adult survivors to understand prior treatments (sometimes given in infancy or early childhood) and advocate for their own health needs. The recently published Childhood Cancer Survivorship: Improving Care and Quality of Life, by the National Institute of Medicine (National Academy Press, 2003), highlights the issues facing long-term survivors but is not the comprehensive reference that this book is. In the chapter on quality of life issues, Dr. Christine Eiser states, "Ultimately, cure is about controlling the disease, but it is also about preserving dreams and maximizing potential." Preserving dreams and maximizing potential of childhood cancer survivors is the focus of the editors of this book and they have succeeded ably.
What People are saying about this
...An excellent addition to the literature regarding the late complications of treating and curing children with cancer.
Volume 67 No 5-6
Oncology - International Journal of Cancer Researc
Although numerous articles have dealt with particular aspects of the late effetcs of treatment for childhod cancer, there is a conspicuous absence of comprehensive discussion of this topic. Hamish Wallace and Daniel Green, two prominent investigators in the field, have done an admirable job of filling this gap. Their book is comprehensive, well referenced, and amply provided with high quality illustrations....
....An impressive contribution to the literature on childhood cancer. It will be a valuable reference for oncologists, pediatricians, internists, and family practitioners, as well as clinicians working in other disciplines. All medical libraries should have this book on their shelves.
The New England Journal of Medecine
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