Late Sequelae in Oncology

Overview

Increasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms.
The objective of the book is to bring together these recent clinical...
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Paperback (Softcover reprint of the original 1st ed. 1995)
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Overview

Increasing survival figures and the use of more intense combined treatment regimens in modern oncology have raised the problem of late therapeutic sequelae in long-term survivors after cancer. Recent scientific approaches to late sequelae concentrate on the evaluation of subclinical changes with sophisticated functional measurements and experimental investigation of the underlying pathophysiological mechanisms.
The objective of the book is to bring together these recent clinical and experimental data from different medical disciplines to give an overview of the most relevant problems of late sequelae. In clinical practice the book may help regarding estimation of risks, selection of diagnostic methods, and estimation of the prognosis of late sequelae.

The book contains black-and-white illustrations.

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Editorial Reviews

Elaine Morgan
This is an informative new book describing late sequelae of cancer treatment and includes areas of both pediatric and medical oncology. Data concerning incidence, etiology, contributing factors, possible prevention and outcome of the delayed effects are included along with areas of current research. The purpose is to provide an overview of the consequences of cancer therapy. This information is essential for following current survivors and for the design of future therapies. This is very timely as the number of long-term survivors of cancer increase. This volume largely meets the objectives. The book targets practicing oncologists and those physicians who may see cancer survivors for routine medical care. There are multiple authors with knowledge in the targeted areas of discussion. The book contains many appropriate graphs and tables as well as fewer numbers of illustrative photographs and radiographs. The references are up-to-date and appropriate in number. The book is simple but very well laid out. This book is well written, comprehensive, and current. It provides practitioners of multiple disciplines with information about late sequelae of cancer treatment that is essential for monitoring and management of survivors as well as for devising less morbid treatment plans for new patients.
From The Critics
Reviewer: Elaine Morgan, MD (Children's Memorial Hospital)
Description: This is an informative new book describing late sequelae of cancer treatment and includes areas of both pediatric and medical oncology. Data concerning incidence, etiology, contributing factors, possible prevention and outcome of the delayed effects are included along with areas of current research.
Purpose: The purpose is to provide an overview of the consequences of cancer therapy. This information is essential for following current survivors and for the design of future therapies. This is very timely as the number of long-term survivors of cancer increase. This volume largely meets the objectives.
Audience: The book targets practicing oncologists and those physicians who may see cancer survivors for routine medical care. There are multiple authors with knowledge in the targeted areas of discussion.
Features: The book contains many appropriate graphs and tables as well as fewer numbers of illustrative photographs and radiographs. The references are up-to-date and appropriate in number. The book is simple but very well laid out.
Assessment: This book is well written, comprehensive, and current. It provides practitioners of multiple disciplines with information about late sequelae of cancer treatment that is essential for monitoring and management of survivors as well as for devising less morbid treatment plans for new patients.

3 Stars from Doody
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Product Details

  • ISBN-13: 9783642467967
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 4/6/2012
  • Series: Medical Radiology / Radiation Oncology Series
  • Edition description: Softcover reprint of the original 1st ed. 1995
  • Edition number: 1
  • Pages: 300
  • Product dimensions: 8.25 (w) x 11.00 (h) x 0.66 (d)

Table of Contents

1 Individual Variation of Radio- and Chemosensitivity.- 1.1 Impact of Endogenous and Exogenous Factors on Radiation Sequelae.- 1.2 Endogenous and Exogenous Factors Modifying Chemosensitivity to Cytostatic Drugs.- 2 Neurotoxicity.- 2.1 Radiation-Induced Injury of the Central Nervous System.- 2.2 Cytostatic-Induced Central Nervous System Abnormalities.- 2.3 Radiation Myelopathy.- 2.4 Acute and Late Toxicity on Peripheral Nerves After Radiotherapy.- 2.5 Acute and Late Toxicity on Peripheral Nerves After Chemotherapy — A Review.- 2.6 Endocrine Dysfunction After Brain Tumor Therapy in Children.- 2.7 Endocrine Dysfunction in Adults After Radiotherapy for Pituitary Adenomas and Suprasellar Tumors.- 2.8 Late Sequelae Affecting the Ear.- 2.9 Ototoxicity in Pediatric Oncology.- 3 Skin and Mucosal Toxicity.- 3.1 Biological Basis for Skin and Mucosal Toxicity.- 3.2 Radiation-Induced Fibrosis: Experimental Studies.- 3.3 Lymphedema of the Arm After Treatment of Breast Cancer.- 3.4 Skin and Mucosal Damage After Radiotherapy for Head and Neck Tumors.- 3.5 Mucosal Toxicity After Radiochemotherapy.- 3.6 Complications of the Small Intestine and the Pancreas After Intraoperative Radiotherapy.- 3.7 Skin Toxicity.- 4 Lung Toxicity.- 4.1 Radiation Pneumopathy — Experimental and Clinical Data.- 4.2 Lung Toxicity of Chemotherapeutic Agents.- 4.3 Differential Diagnosis of Treatment Sequelae in the Lung.- 5 Cardiotoxicity.- 5.1 Evaluation of Late Cardiotoxicity by Pulsed Doppler Echocardiography in Patients Treated for Hodgkin’s Disease.- 5.2 Anthracycline-Induced Cardiotoxicity in Children: Pathophysiology and Prevention.- 5.3 Radiation-Induced Cardiotoxicity: Experimental Data.- 5.4 Cardiotoxicity After Megavoltage Irradiation and Chemotherapy for Hodgkin’s Disease with Special Emphasis on Coronary Heart Disease Mortality — The Freiburg Experience 1940-1992.- 5.5 Cardiac Morbidity and Mortality Followig Radiotherapy.- 6 Nephrotoxicity.- 6.1 Nephrotoxicity of Ifosfamide in Children.- 6.2 Radiation Nephritis.- 7 Gonadal Toxicity.- 7.1 Long-Term Gonadal Dysfunction and Its Impact on Bone Mineralization in Patients Following COPP/ABVD Chemotherapy for Hodgkin’s Disease.- 7.2 Gonadal Dysfunction After Radiotherapy.- 8 Disturbances of Sceletal Growth.- 8.1 Dose-Time Considerations for Skeletal Growth Disturbances After Radiotherapy.- 8.2 Disturbances in Growth of Bone, Muscle, and Fat Tissue Following Irradiation in Childhood.- 8.3 Growth Failure Secondary to Radiotherapy of Brain Tumors in Childhood.- 9 Cancerogenesis.- 9.1 Experiments on the Carcinogenic Potential of Antineoplastic Agents.- 9.2 Secondary Malignancies Following Cytotoxic Chemotherapy.- 9.3 Secondary Malignancies After Radiotherapy.- List of Contributors.
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