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LC-MS in Drug Analysis: Methods and Protocols

Overview

Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Prools provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following ...

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Overview

Liquid-Chromatography-Mass-Spectrometry procedures have been shown to be successful when applied to drug development and analysis. LC-MS in Drug Analysis: Methods and Prools provides detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance. The first chapters provide the reader with an overview of mass spectroscopy, its place in clinical practice, its application of MS to TDM and toxicology, and the merits of LC-MS(/MS) and new sample preparation techniques. The following chapters discuss different approaches to screening for drugs of abuse and for general unknowns, as well as targeted measurement of specific analytes or classes of analytes including abused drugs, toxic compounds, and therapeutic agents. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible prools, and notes on troubleshooting and avoiding known pitfalls.

Authoritative and easily accessible, LC-MS in Drug Analysis: Methods and Prools seeks to serve both professionals and novices with its well-honed methodologies.

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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is a compilation of LC-MS/MS technical procedures for drug analysis.
Purpose: It is intended to "provide detailed LC-MS/MS procedures for the analysis of several compounds of clinical significance."
Audience: It is written for practicing toxicologists or clinical chemists whose daily practice includes analysis for these clinically important substances. It also would be of interest to anyone curious about clinical laboratory testing for any of these compounds or interested in clinical applications of LC-MS/MS.
Features: This deceptively thin book is a real treasure trove. Aside from the first two introductory chapters, the remaining 17 are detailed protocols for LC-MS/MS analysis for various compounds. This book is not for the faint of heart — you must be a dedicated chemist/toxicologist to see the true value. The protocols in each chapter define high complexity testing. For those accustomed to load and walk away automated testing instruments, these protocols will take you back to laboratory science training or undergraduate chemistry lab. You'll need to be able to prepare all solutions from scratch — i.e., be competent in preparing analytical grade stock solutions, reagent or specimen dilutions, adjusting pHs, preparing solvents for the various phases, etc. A significant portion is devoted to substance abuse compounds (benzodiazepines, opiates, cocaine, cannabinoids, amphetamines, etc.). There are also protocols for infrequent but clinically important situations, such as hypoglycemic agents, rodenticide anticoagulants, immunosuppressive drugs, antipsychotics, etc. The major strengths of this book are the incredibly detailed protocols and helpful notes. The only minor weaknesses are relatively small chromatograph examples in certain chapters (e.g., figure 1, chapter 9) and the plethora of acronyms.
Assessment: You will need this book if you are involved in LC-MS/MS analysis for compounds of clinical interest. Having these varied and detailed protocols in a single book is priceless.
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Product Details

  • ISBN-13: 9781617799334
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 7/6/2012
  • Series: Methods in Molecular Biology Series , #902
  • Edition description: 2012
  • Edition number: 1
  • Pages: 224
  • Product dimensions: 7.10 (w) x 10.10 (h) x 0.70 (d)

Table of Contents

1. An Introduction to Drug Testing – The Expanding Role of Mass Spectrometry

Catherine Hammett-Stabler and Steven W. Cotton

2. LC-MS vs. GC-MS, Online Extraction Systems, Advantages of Technology for Drug Screening Assays

Pierre Marquet

3. LC-MS/MS Techniques for High Volume Screening of Drugs of Abuse and Target Drug Quantitation in Urine/Blood Matrices

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry

Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda

5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

6. Synthetic Opioid Analysis by LC-MS/MS

David M. Garby and Lynn A. Cheryk

7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection

Oscar Quintela and Dennis J. Crouch

8. Cocaine and Metabolites by LC-MS/MS

Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman

9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control

Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch

11. LC-MS/MS Screen for Xenobiotics and Metabolites

François-Ludovic Sauvage and Pierre Marquet

12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

13. Hypoglycemic Agent Screening by LC-MS/MS

Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek

14. LC-MS/MS Method for the Detection of Common Laxatives

Robert A. Middleberg and Joseph Homan

15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS)

Uttam Garg, Ada Munar, and C. Clinton Frazee III

16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS

Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin

17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS

Elizabeth R. Kiely and Heather M. Antonides

18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry

Jennifer A. Collins and Gregory C. Janis

19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry

Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda

5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

6. Synthetic Opioid Analysis by LC-MS/MS

David M. Garby and Lynn A. Cheryk

7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection

Oscar Quintela and Dennis J. Crouch

8. Cocaine and Metabolites by LC-MS/MS

Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman

9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control

Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch

11. LC-MS/MS Screen for Xenobiotics and Metabolites

François-Ludovic Sauvage and Pierre Marquet

12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

13. Hypoglycemic Agent Screening by LC-MS/MS

Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek

14. LC-MS/MS Method for the Detection of Common Laxatives

Robert A. Middleberg and Joseph Homan

15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS)

Uttam Garg, Ada Munar, and C. Clinton Frazee III

16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS

Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin

17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS

Elizabeth R. Kiely and Heather M. Antonides

18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry

Jennifer A. Collins and Gregory C. Janis

19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry

Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda

5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

6. Synthetic Opioid Analysis by LC-MS/MS

David M. Garby and Lynn A. Cheryk

7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection

Oscar Quintela and Dennis J. Crouch

8. Cocaine and Metabolites by LC-MS/MS

Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman

9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control

Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch

11. LC-MS/MS Screen for Xenobiotics and Metabolites

François-Ludovic Sauvage and Pierre Marquet

12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

13. Hypoglycemic Agent Screening by LC-MS/MS

Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek

14. LC-MS/MS Method for the Detection of Common Laxatives

Robert A. Middleberg and Joseph Homan

15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS)

Uttam Garg, Ada Munar, and C. Clinton Frazee III

16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS

Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin

17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS

Elizabeth R. Kiely and Heather M. Antonides

18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry

Jennifer A. Collins and Gregory C. Janis

19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

4. Benzodiazepines and Metabolites from Biological Fluids by Liquid Chromatography Electrospray Tandem Mass Spectrometry

Cynthia L. Morris-Kukoski, Jason E. Schaff, and Louis J. Reda

5. Opiate Screening and Quantitation in Urine/Blood Matrices using LC-MS/MS Techniques

Jeff C. Eichhorst, Michele L. Etter, Patricia L. Hall, and Denis C. Lehotay

6. Synthetic Opioid Analysis by LC-MS/MS

David M. Garby and Lynn A. Cheryk

7. The Determination of Cannabinoids Using Liquid Chromatography with Mass Spectrometric Detection

Oscar Quintela and Dennis J. Crouch

8. Cocaine and Metabolites by LC-MS/MS

Christine L. H. Snozek, Matthew W. Bjergum, and Loralie J. Langman

9. Quantitation of Amphetamine Type Stimulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

10. Detection of Prohibited Substances by Liquid Chromatography Tandem Mass Spectrometry for Sports Doping Control

Brian D. Ahrens, Borislav Starcevic, and Anthony W. Butch

11. LC-MS/MS Screen for Xenobiotics and Metabolites

François-Ludovic Sauvage and Pierre Marquet

12. Qualitative Identification of Rodenticide Anticoagulants by LC-MS/MS

Robert A. Middleberg and Joseph Homan

13. Hypoglycemic Agent Screening by LC-MS/MS

Eric W. Korman, Loralie J. Langman, and Christine L. H. Snozek

14. LC-MS/MS Method for the Detection of Common Laxatives

Robert A. Middleberg and Joseph Homan

15. Simultaneous Determination of Cyclosporine, Sirolimus and Tacrolimus in Whole Blood Using Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS)

Uttam Garg, Ada Munar, and C. Clinton Frazee III

16. Quantification of Tricyclic Antidepressants Using UPLC-MS/MS

Kamisha L. Johnson-Davis, JoEtta M. Juenke, Rebecka Davis, and Gwendolyn A. McMillin

17. Quantitation of First- and Second-Generation Antipsychotics by LC-MS/MS

Elizabeth R. Kiely and Heather M. Antonides

18. Analysis of Selected Anticonvulsants by High Performance Liquid Chromatography-Tandem Mass Spectrometry

Jennifer A. Collins and Gregory C. Janis

19. Therapeutic Drug Monitoring of Tamoxifen Using LC-MS/MS

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

Simone M. Tchu, Kara L. Lynch, and Alan H. B. Wu

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