Lead Generation Approaches in Drug Discovery / Edition 1

Lead Generation Approaches in Drug Discovery / Edition 1

by Zoran Rankovic, Richard Morphy
     
 

ISBN-10: 047025761X

ISBN-13: 9780470257616

Pub. Date: 03/29/2010

Publisher: Wiley

An integrated overview of modern approaches to lead discovery

Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by

Overview

An integrated overview of modern approaches to lead discovery

Lead generation is increasingly seen as a distinct and success-determining phase of the drug discovery process. Over recent years, there have been major advances in the understanding of what constitutes a good lead compound and how to improve the chances of finding such a compound. Written by leading scientists and established opinion leaders from industry and academia, this book provides an authoritative overview of the field, as well as the theory, practice, and scope, of the principal Lead Generation Approaches in Drug Discovery, including:

  • The evolution of the lead discovery process, key concepts, current challenges, and future directions

  • Strategies and technologies driving the high-throughput screening (HTS) approach to lead discovery, including the shifting paradigms in the design of compound collections and best practice in the hit confirmation process

  • Knowledge-based in silico or "virtual" screening

  • Theory and practice of the fragment-based approach to lead discovery

  • The opportunities and challenges presented by multi-target drug discovery (MTDD)

  • De novo design of lead compounds and new approaches to estimating the synthetic accessibility of de novo–designed molecules

  • The impact of natural products on drug discovery, and potential of natural product–like compounds for exploring regions of biologically relevant chemical space

  • Using early screening of hits and leads for metabolic, pharmacokinetic, and toxicological liabilities to reduce attrition during the later phases of drug discovery

  • The utility of parallel synthesis and purification in lead discovery

With each topic supported by numerous case studies, this is indispensable reading for researchers in industry and academia who wish to keep up to date with the latest strategies and approaches in drug discovery.

Product Details

ISBN-13:
9780470257616
Publisher:
Wiley
Publication date:
03/29/2010
Pages:
295
Product dimensions:
6.10(w) x 9.30(h) x 0.80(d)

Related Subjects

Table of Contents

Preface vii

Contributors xi

1 Lead Discovery: The Process William F. Michne 1

2 High Throughput Screening Approach to Lead Discovery Zoran Rankovic Craig Jamieson Richard Morphy 21

3 In Silico Screening Dagmar Stumpfe Hanna Geppert Jürgen Bajorath 73

4 Fragment-Based Lead Discovery Jeffrey S. Albert 105

5 Design of Multitarget Ligands Richard Morphy Zoran Rankovic 141

6 De novo Drug Design Gisbert Schneider Markus Hartenfeller Ewgenij Proschak 165

7 Role of Natural Products in Drug Discovery Hugo Lachance Stefan Wetzel Herbert Waldmann 187

8 Early Screening for ADMET Properties Dennis A. Smith 231

9 Role of Chemistry in Lead Discovery Roland E. Dolle Karin Worm 259

Index 291

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