Lehninger Principles of Biochemistry / Edition 3

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This undergraduate textbook describes the structure and function of the major classes of cellular constituents, and explains the physical, chemical, and biological context in which each biomolecule, reaction, and pathway operates. The fourth edition adds a chapter on the regulation of metabolism, reflects recent advances, and incorporates new experimental methodologies and an expanded and redesigned treatment of reaction mechanisms. Annotation ©2004 Book News, Inc., Portland, OR
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Editorial Reviews

From The Critics
Reviewer: Eugene A Davidson, PhD(Georgetown University School of Medicine)
Description: This comprehensive biochemical text covers all aspects of modern biochemistry, together with many new developments since the previous edition of four years ago.
Purpose: The goal is to provide students with a thorough biochemistry text. Given the overall importance of modern biochemistry (broadly writ), this is a worthwhile objective. In general, the goals are met.
Audience: The target audience includes senior undergraduate, graduate, and medical students. The authors are both knowledgeable and experienced.
Features: There are several comprehensive biochemistry texts available. The fourth edition of Lehninger draws on a successful history initiated with the first edition which was a landmark text in its time. The 28 chapters follow an expected and logical progression from discussion of the fundamental molecules involved in cellular events through metabolism to the latest aspects of molecular biology. Illustrations are well done and frequent. Each chapter is accompanied by a short but useful bibliography and a set of problems. Problem answers are at the end, together with a detailed glossary and a thorough index. In an attempt to capture as broad a student audience as possible, discussions of both photosynthesis and metabolic diseases are offered. Thus, the material can be used in undergraduate/graduate courses as well as in medical school. As with other representatives of this text style, the typical student is likely to have some difficulty assigning relative importance to a given item considering the overall depth of coverage oftopics. Nevertheless, careful reading with some guidance will be rewarding for most scholars and the book will serve as companion text for the usual biochemistry course. The bibliography is not as complete as some, but will provide pointers to additional material. A useful, albeit formidable (for the student) contribution.
Assessment: This is yet another mega-text, seeking to satisfy all audiences. Not easy for the average student to read, but all of the material is there. Competitors include Voet and Voet, Biochemistry, 3rd edition (John Wiley & Sons, 2004); Devlin, Textbook of Biochemistry with Clinical Correlations, 6th edition (John Wiley & Sons, 2006) (medical focus); and Metzler, The Chemical Reactions of Living Cells, 2nd edition (Elsevier, 2003) (somewhat more comprehensive with an extraordinary bibliography). Is the new edition needed?? Probably, but most students will still be able to use the earlier version. Conversely, other publishers put out new editions, so this one has to.
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Product Details

  • ISBN-13: 9780716742210
  • Publisher: Freeman, W. H. & Company
  • Publication date: 1/28/2000
  • Edition description: Older Edition
  • Edition number: 3

Table of Contents

1 The foundations of biochemistry 1
2 Water 47
3 Amino acids, peptides, and proteins 75
4 The three-dimensional structure of proteins 116
5 Protein function 157
6 Enzymes 190
7 Carbohydrates and glycobiology 238
8 Nucleotides and nucleic acids 273
9 DNA-based information technologies 306
10 Lipids 343
11 Biological membranes and transport 369
12 Biosignaling 421
13 Principles of bioenergetics 489
14 Glycolysis, gluconeogensis, and the pentose phosphate pathway 521
15 Principles of metabolic regulation : glucose and glycogen 560
16 The citric acid cycle 601
17 Fatty acid catabolism 631
18 Amino acid oxidation and the production of urea 656
19 Oxidative phosphorylation and photophosphorylation 690
20 Carbohydrate biosynthesis in plants and bacteria 751
21 Lipid biosynthesis 787
22 Biosynthesis of amino acids, nucleotides, and related molecules 833
23 Hormonal regulation and integration of mammalian metabolism 881
24 Genes and chromosomes 923
25 DNA metabolism 948
26 RNA metabolism 995
27 Protein metabolism 1034
28 Regulation of gene expression 1081
App. A Common abbreviations in the biochemical research literature
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