Leukemia

Overview

An international roster of field-leading experts delivers the seventh edition of the definitive textbook, LEUKEMIA. This classic provides comprehensive guidance on all aspects of leukemia, from etiology and biology to clinical features and therapy. This edition now also provides the molecular basis of several leukemias. It reflects the most exciting period of research in the field in a quarter century, and features information on molecular biology and molecular genetics, as well...

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Overview

An international roster of field-leading experts delivers the seventh edition of the definitive textbook, LEUKEMIA. This classic provides comprehensive guidance on all aspects of leukemia, from etiology and biology to clinical features and therapy. This edition now also provides the molecular basis of several leukemias. It reflects the most exciting period of research in the field in a quarter century, and features information on molecular biology and molecular genetics, as well as biological therapy.

The book contains both black-and-white and color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Martin Stuart Tallman, MD, MD (Northwestern University Feinberg School of Medicine)
Description: This seventh edition of a well-respected book provides current information on the biology, clinical manifestations and treatment of all of the leukemias. Importantly, attention is given to the burgeoning area of targeted strategies. The first edition was published in 1958 by Drs. Dameshek and Gunz, two legends in the field, and this new edition includes chapters written authoritatively by the major figures in the field today.
Purpose: The purpose of this edition is to convey the sense of real progress that has been made in the understanding and treatment of leukemia. This is a very laudable objective given the remarkable insights into the molecular biology and the translation of these insights to changes in treatment which have improved the outcomes for many patients. With this book, the reader is indeed imbued with a genuine sense of excitement about the field.
Audience: The book is written for any individual interested in learning about almost any aspect of leukemia including from a historical perspective. Medical students, house officers, nurses, fellows, and specialists in the field of hematology-oncology will find every chapter of interest.
Features: The chapters cover the entire field, including the history of the disease, which is particularly fascinating, possible viral etiologies, molecular genetics of the leukemia cell which has played such a major role in our evolution in treatment with more targeted therapies such as all-trans-retinoic acid and arsenic trioxide, both for acute promyelocytic leukemia, the antibodies Rituxan and Campath-1H for chronic lymphocytic leukemia, the immunoconjugate BL22 for hairy cell leukemia, and imatinib mesylate for chronic myeloid leukemia, and transplantation. Appropriately, a separate chapter is devoted to acute promyelocytic leukemia. Chapters addressing both bleeding and thrombosis in the patient with leukemia and the common problem of anemia are particularly helpful. Chapters discussing monoclonal antibodies, immunoconjugates and antisense strategies are timely. The comprehensive chapter addressing minimal residual disease is also particularly important since the presence of such minimal disease is beginning to guide our therapy, particularly in acute lymphoblastic leukemia. In addition, the availability of agents such as imatinib mesylate makes this goal critically important.
Assessment: Given the unprecedented and rapid changes in our understanding of the biology and treatment approaches for the various leukemias, this book is a welcome addition to the shelves of anyone interested keeping current in the field of leukemia or involved in the treatment of such patients. This book is particularly easy to read and each topic is entirely covered in one or two chapters. An eighth edition will be required, eagerly anticipated, and enthusiastically welcomed.
Martin S. Tallman
This is the sixth edition of what has become a well-recognized text in leukemia. It is comprehensive in its attempt to cover the etiology, pathogenesis, clinical features, management, and complications of all types of acute and chronic leukemias. The authors intend to keep abreast of the many rapid changes in the molecular basis of acute leukemia, advances in treatment strategies, cytogenetics, immunophenotyping,and therapeutic strategies, including the role of hematopoietic growth factors and all-trans retinoic acid in acute promyelocytic leukemia. The goals of the authors are well justified; indeed, they meet their objectives fully. This book is written for a broad audience, including students, house officers, and hematologists/oncologists, but it will be very informative for the nonhematologist physician as well. The authors have solicited chapters from leading authorities in their fields, and the text is edited so that there is a logical sequence of topics. The chapters are written in a way that is easy to understand. All chapters have an extensive number of references. There are numerous illustrations that satisfactorily enhance the text. The table of contents and index are similarly easy to use. There are numerous well-reproduced color photomicrographs that add to the overall appearance of the text. The chapter on biologic therapy of leukemia is particularly timely and thorough. This sixth edition will be a useful addition for any institutional or personal library. The authors have succeeded in addressing the many new advances in the field, including our improved ability to use cytogenetics, immunophenotyping, and molecular genetics to understand, classify, and treat thevarious leukemias. The easy readability will make this book particularly useful for house officers and fellows.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780721690605
  • Publisher: Elsevier Health Sciences
  • Publication date: 5/14/2002
  • Edition description: REV
  • Edition number: 7
  • Pages: 528
  • Product dimensions: 8.78 (w) x 11.10 (h) x 1.55 (d)

Table of Contents

Introduction
History
Biology

NL Blood Production
Myelopoiesis
Lymphopoiesis

Diagnosis
Clinical
Morphology/Cytochemisty
Cytog/Molecular Genetics

Etiology
Overview
Descriptive Epidemiology
Heredity
Radiation
Chemical
HTLV-1
Congenital
New Insights

Therapy
Problems/solutions
Infections
Bleeding
Anemia
Chemotherapy
Immunotherapy
Gene Rx
Transplant
Monitoring Rx

Treatment of Specific Disease
AML Adult
AML Child
APL
ALL Child
ALL Adult
MDS
CML
CLL
HCL
ATLL

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