Linkage Thermodynamics Of Macromolecular Interactions / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$167.79
Used and New from Other Sellers
Used and New from Other Sellers
from $89.27
Usually ships in 1-2 business days
(Save 50%)
Other sellers (Hardcover)
  • All (3) from $89.27   
  • New (2) from $169.10   
  • Used (1) from $89.27   

Overview

This volume commemorates the 50th anniversary of the appearance in Volume 4 in 1948 of Dr. Jeffries Wyman's famous paper in which he "laid down" the foundations of linkage thermodynamics. Experts in this area contribute articles on the state-of-the-art of this important field and on new developments of the original theory. Among the topics covered in this volume are electrostatic contributions to molecular free energies in solution; site-specific analysis of mutational effects in proteins; allosteric transitions of the acetylcholine receptor; and deciphering the molecular code of hemoglobin allostery.

Audience: Biochemists, molecular biologists, biophysicists, and biomedical researchers.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Gene A. Homandberg, PhD (Rush Medical College of Rush University)
Description: This Advances in Protein Chemistry volume on linkage thermodynamics of macromolecular interactions introduces and updates topics dealing with the role of electrostatic contributions to free energies of soluble molecules, analysis of mutational effects on protein interactions, allosteric transitions of acetylcholine receptor, hemoglobin allostery, statistical thermodynamic linkage between conformations and binding equilibria, effects of salts and solutes on protein and nucleic acid equilibria, and effect of cosolvents on protein stability and reactions.
Purpose: It is meant to present selected topics on the role of linkage thermodynamics in explaining protein folding, protein stability, allostery, and protein-ligand interaction. The contributions are by outstanding investigators who bring both a traditional perspective on this topic and expertise and knowledge in newer aspects and applications, such as protein-nucleic acid interactions.
Audience: The material is aimed at the specialist, but an introduction or overview for the less initiated would have been helpful. Nonetheless, any investigator with interests in protein folding and stability, or protein-protein or protein-ligand interaction thermodynamics or in enzyme or receptor interaction thermodynamics should find this volume useful and informative.
Features: This attractive volume is of the quality of all of the books in the series and has the typical high quality text, figures, and subject index.
Assessment: This volume is highly recommended for protein chemists, molecular or cell biologists who need a better understanding of these topics. With such a detailed overview of these specific concepts, there is something in these chapters for everyone.
From the Publisher
Praise for the Volume
"The contributions are by outstanding investigators who bring both a traditional perspective on this topic and expertise and knowledge in newer aspects and applications, such as protein-nucleic acid interactions...any investigator with interests in protein folding and stability, or protein-protein or protein-ligand interaction thermodynamics or in enzyme or receptor interaction thermodynamics should find this volume useful and informative... This volume is highly recommended for protein chemists, molecular or cell biologists who need a better understanding of these topics."
—DOODY'S PUBLISHING REVIEWS (4 star rating)
Praise for the Series
"The authority, originality, and editing of the reviews are first class."
—NATURE
"The Advances in Protein Chemistry series has been a major factor in the education of protein chemists."
—JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
From The Critics
Reviewer: Gene A. Homandberg, PhD (Rush Medical College of Rush University)
Description: This Advances in Protein Chemistry volume on linkage thermodynamics of macromolecular interactions introduces and updates topics dealing with the role of electrostatic contributions to free energies of soluble molecules, analysis of mutational effects on protein interactions, allosteric transitions of acetylcholine receptor, hemoglobin allostery, statistical thermodynamic linkage between conformations and binding equilibria, effects of salts and solutes on protein and nucleic acid equilibria, and effect of cosolvents on protein stability and reactions.
Purpose: It is meant to present selected topics on the role of linkage thermodynamics in explaining protein folding, protein stability, allostery, and protein-ligand interaction. The contributions are by outstanding investigators who bring both a traditional perspective on this topic and expertise and knowledge in newer aspects and applications, such as protein-nucleic acid interactions.
Audience: The material is aimed at the specialist, but an introduction or overview for the less initiated would have been helpful. Nonetheless, any investigator with interests in protein folding and stability, or protein-protein or protein-ligand interaction thermodynamics or in enzyme or receptor interaction thermodynamics should find this volume useful and informative.
Features: This attractive volume is of the quality of all of the books in the series and has the typical high quality text, figures, and subject index.
Assessment: This volume is highly recommended for protein chemists, molecular or cell biologists who need a better understanding of these topics. With such a detailed overview of these specific concepts, there is something in these chapters for everyone.
Gene A. Homandberg
This Advances in Protein Chemistry volume on linkage thermodynamics of macromolecular interactions introduces and updates topics dealing with the role of electrostatic contributions to free energies of soluble molecules, analysis of mutational effects on protein interactions, allosteric transitions of acetylcholine receptor, hemoglobin allostery, statistical thermodynamic linkage between conformations and binding equilibria, effects of salts and solutes on protein and nucleic acid equilibria, and effect of cosolvents on protein stability and reactions. It is meant to present selected topics on the role of linkage thermodynamics in explaining protein folding, protein stability, allostery, and protein-ligand interaction. The contributions are by outstanding investigators who bring both a traditional perspective on this topic and expertise and knowledge in newer aspects and applications, such as protein-nucleic acid interactions. The material is aimed at the specialist, but an introduction or overview for the less initiated would have been helpful. Nonetheless, any investigator with interests in protein folding and stability, or protein-protein or protein-ligand interaction thermodynamics or in enzyme or receptor interaction thermodynamics should find this volume useful and informative. This attractive volume is of the quality of all of the books in the series and has the typical high quality text, figures, and subject index. This volume is highly recommended for protein chemists, molecular or cell biologists who need a better understanding of these topics. With such a detailed overview of these specific concepts, there is something in these chapters for everyone.
Alvin Telser
This is a very thorough and timely presentation of the protein chemistry and biology of four-helix cytokines. It is Volume 52 in the series Advances in Protein Chemistry. The editor describes this volume as a presentation and discussion of cytokines from a molecular and structural perspective to their cellular and physiological roles. These molecules are widely distributed in many phyla, and their actions are physiologically very important. Therefore, these objectives are worthwhile and are very well attained. This volume is intended for knowledgeable researchers as well as for individuals who wish to become informed about this field. This in an appropriate audience. The contributors of the six chapters are well known experts in each of the fields discussed. In the first three chapters the common structural features of these molecules and the signaling mechanisms they employ are presented. The last three chapter contributors discuss many cellular, physiological, and roles of cytokines. The book has no special features and no significant shortcomings. This book will be of interest and value to anyone wishing to learn and understand about structure-function relationships of this large class of cytokines. It is a very good book and should be in the collection of any life science library.

4 Stars! from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780120342518
  • Publisher: Elsevier Science
  • Publication date: 5/1/1998
  • Edition number: 1
  • Pages: 484
  • Product dimensions: 1.25 (w) x 6.00 (h) x 9.00 (d)

Table of Contents

M. Schaefer, H. van Vlijmen, and M. Karplus, Electrostatic Contributions to Molecular Free Energies in Solution.
E. Di Cera, Site-Specific Analysis of Mutational Effects in Proteins.
S.J. Edelstein and J.-P. Changeux, Allosteric Transitions of the Acetylcholine Receptor.
G.K. Ackers, Deciphering the Molecular Code of Hemoglobin Allostery.
E. Freire, Statistical Thermodynamic Linkage between Conformational and Binding Equilibria.
M.T. Record, Jr., W. Zhang, and C.F. Anderson, Analysis of the Effects of Salts and Uncharged Solutes on Protein and Nucleic Acid Equilibria and Processes: A Practical Guide to Recognizing and Interpreting Polyelectrolyte Effects, Hofmeister Effects, and Osmotic Effects of Salts.
S.N. Timasheff, Control of Protein Stability and Reactions by Weakly Interacting Cosolvents: The Simplicity of the Complicated.
Author Index.
Subject Index.

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)