Lipid Metabolism in the Healthy and Disease Heart / Edition 1

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1992 Hardback NEW 9780792318507 Hardback, This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. *****PLEASE NOTE: ... This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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The Third International Symposium on Lipid Metabolism in the Normoxic and Ischemic Heart was held in Rotterdam, the Netherlands, September 9-10, 1991.
The topics of this meeting were focused on: 1. Modulation of myocardial lipid metabolism, 2. Biological membranes; structure, functiona and turnover, 3. Pharmacological modification of myocardial fatty acid oxidation, 4. Myocardial vascular endothelium; contribution to myocardial lipid homeostasis.
Special attention is given to the interrelationship between carbohydrates and fatty acids as energy substrates for the heart under normoxic and (post) ischemic circumstances, the influence of diets, varying in their fatty acid composition, on cardiac function, and the significance of phospholipid topology, turnover, and methylation in general and the phosphatidylinositol pathway in particular on performance of the heart. The role of carnitine in cardiac function altered by lack of oxygen or by elevated levels of fatty acyl derivatives of carnitine and the modulatory effects of the endothelium on cardiac lipid homeostasis were also extensively discussed during the conference.
This focused Issue of Molecular and Cellular Biochemistry is a collection of invited papers based on the lectures and a selection of posters presented during the meeting. It includes contributions of renowned investigators delineating recent results and discussing significant aspects of their data in an attempt to enlarge our insight in the complexity of cardiac lipid transport and metabolism, in the healthy and diseased myocardium.

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Table of Contents

Preface 1
Paradoxical role of lipid metabolism in heart function and dysfunction 3
Interrelationship between lactate and cardiac fatty acid metabolism 11
Dietary modulation of lipid metabolism and mechanical performance of the heart 19
The substrate specificity of phosphoinositide-phospholipase C in rat heart sarcolemma 27
Long term incubation of cardiac myocytes with oleic acid and very low density lipoprotein reduces heparin-releasable lipoprotein lipase activity 33
Carnitine palmitoyltransferase in the heart is controlled by a different mechanism than the hepatic enzyme 39
Myocardial cell vulnerability to exogenous phospholipase attack 47
Phosphatidylcholine metabolism in ischemic and hypoxic hearts 53
Occurrence and functions of the phosphatidylinositol cycle in the myocardium 59
Modulation of phosphatidylethanolamine biosynthesis by exogenous ethanolamine and analogues in the hamster heart 69
Eicosapentaenoic and docosahexaenoic cultured rat ventricular myocytes and hypoxia-induced alterations of phospholipase-A activity 75
Incorporation of radioiodinated fatty acids into cardiac phospholipids of normoxic canine myocardium 79
Kinetic changes of ethanolamine base exchange activity and increase of viscosity in sarcolemmal membranes of hamster heart during development of cardiomyopathy 89
Annexins in cardiac tissue: cellular localization and effect on phospholipase activity 95
Myocardial fatty acid oxidation during ischemia and reperfusion 103
The relative contribution of glucose and fatty acids to ATP production in hearts reperfused following ischemia 111
Effects of palmitoyl CoA and palmitoyl carnitine on the membrane potential and Mg[superscript 2+] content of rat heart mitochondria 117
Carnitine requirement of vascular endothelial and smooth muscle cells in imminent ischemia 125
Protection of the ischemic diabetic heart by L-propionylcarnitine therapy 131
Functional and metabolic effects of propionyl L-carnitine in the isolated perfused hypertrophied rat heart 139
L - propionylcarnitine and myocardial performance in stunned porcine myocardium 147
Release of heart fatty acid-binding protein into plasma after acute myocardial infarction in man 155
Regulatory functions of the coronary endothelium 163
Lipid metabolism of myocardial endothelial cells 171
Endothelium, the dynamic interface in cardiac lipid transport 181
Malondialdehyde is a biochemical marker of peroxidative damage in the isolated reperfused rat heart 193
Studies on the interaction of leucocytes and the myocardial vasculature. I. Effect of hypoxia on the adherence of blood granulocytes 197
Arachidonic acid incorporation in cardiomyocytes, endothelial cells and fibroblast-like cells isolated from adult rat heart 203
Index 211
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