Lipids and Syndromes of Insulin Resistance: From Molecular Biology to Clinical Medicine

Lipids and Syndromes of Insulin Resistance: From Molecular Biology to Clinical Medicine

by Iwar Klimes

ISBN-10: 1573310719

ISBN-13: 9781573310710

Pub. Date: 09/01/1997

Publisher: New York Academy of Sciences

Product Details

New York Academy of Sciences
Publication date:
Annals of the New York Academy of Sciences Ser.

Table of Contents

Keynote Address: Progress in Population Analyses of the Insulin Resistance Syndrome1
Part I.Animal Models of the Insulin Resistance Syndrome
Hypertension and the Insulin Resistance Syndrome of Rats: Are They Related?13
Obesity Genes and Insulin Resistance Syndrome35
Development of Obesity and Insulin Resistance in the Israeli Sand Rat (Psammomys obesus): Does Leptin Play a Role?50
Diabetes and Hypertension in Rodent Models64
Insulin Resistance Syndrome in Mice Deficient in Insulin Receptor Substrate-185
WOK.1W Rats: A Potential Animal Model of the Insulin Resistance Syndrome94
Part II.Molecular Biology of Syndromes of Insulin Resistance
Lipid Transport Genes and Their Relation to the Syndrome of Insulin Resistance100
Progress in Determining the Genes for Hypertension, Insulin Resistance, and Dyslipidemia110
Hyperinsulinemia and Sympathoadrenal System Activity in the Rat118
Is a Mutation of the [beta subscript 3]-Adrenergic Receptor Gene Related to Non-Insulin-dependent Diabetes Mellitus and Juvenile Hypertension in the Czech Population?135
Glucose Transport and Insulin Signaling in Rat Muscle and Adipose Tissue: Effect of Lipid Availability144
Cafestol (a Coffee Lipid) Decreases Uptake of Low-Density Lipoprotein (LDL) in Human Skin Fibroblasts and Liver Cells158
High Fructose Feeding Enhances Erythrocyte Carbonic Anhydrase 1 mRNA Levels in Rat163
Pharmacological Treatment and Mechanisms of Insulin Resistance: Impact on Vascular Smooth Muscle Cells, Blood Pressure, and Lipids170
Part III.Role of Lipids in Diseases of Insulin Resistance
Fatty Acid Regulation of Gene Expression: Its Role in Fuel Partitioning and Insulin Resistance178
Impact of Dietary Fatty Acid Composition on Insulin Action at the Nucleus188
Molecular and Cellular Determinants of Triglyceride Availability200
Dietary Fatty Acids, Insulin Resistance, and Diabetes215
Lipid Abnormalities in Muscle of Insulin-resistant Rodents: The Malonyl CoA Hypothesis221
Pharmacological Strategies for Reduction of Lipid Availability231
Effect of Oral Antidiabetics and Insulin on Lipids and Coronary Heart Disease in Non-Insulin-dependent Diabetes Mellitus246
Relationships between Fatty Acid Composition and Insulin-induced Oxidizability of Low-Density Lipoproteins in Healthy Men269
Small Dense Low-Density Lipoprotein (LDL) in Non-Insulin-dependent Diabetes Mellitus (NIDDM): Impact of Hypertriglyceridemia279
Part IV.Dietary Fats in Diseases of Insulin Resistance
Does Dietary Fat Influence Insulin Action?287
Monounsaturated and Marine [omega]-3 Fatty Acids in NIDDM Patients302
Omega-3 and Omega-6 Fatty Acids in the Insulin Resistance Syndrome: Lipid and Lipoprotein Metabolism and Atherosclerosis310
Omega-6/Omega-3 Fatty Acid Ratio and Trans Fatty Acids in Non-Insulindependent Diabetes Mellitus327
Dietary Fats and Hypertension: Focus on Fish Oil339
Postprandial Triglyceride High Response and the Metabolic Syndrome353
Evaluation of an Omega-3 Fatty Acid Supplement in Diabetics with Microalbuminuria369
Paleodiet and Its Relation to Atherosclerosis382
Part V.Energy Balance, Lipids, and Obesity
Passive Overconsumption: Fat Intake and Short-Term Energy Balance392
Dietary Fats and Thermogenesis408
Fat Metabolism in the Predisposition to Obesity417
Fat and Energy Balance431
Recent Advances in the Pharmacological Control of Energy Balance and Body Weight449
Fat Substitutes and Energy Balance461
Nonesterified Fatty Acid Regulation of Lipid and Glucose Oxidation in the Obese476
Part VI.Poster Papers
Nuclear All-trans Retinoic Acid Receptors in Liver of Rats with Diet-induced Insulin Resistance480
Diet-induced Insulin Resistance Is Associated with Decreased Activity of Type I Iodothyronine 5'-Deiodinase in Rat Liver485
Insulin and Catecholamines Act at Different Stages of Rat Liver Regeneration489
Fatty Acid Composition in Fractions of Structural and Storage Lipids in Liver and Skeletal Muscle of Hereditary Hypertriglyceridemic Rats494
Increased Adipose Tissue Lipolysis in a Hypertriglyceridemic Rat Line510
Structural Changes in the Aorta of the Hereditary Hypertriglyceridemic Rat514
Increased Lipoprotein Oxidability and Aortic Lipid Peroxidation in an Experimental Model of Insulin Resistance Syndrome521
Phenotype and Genotype Comparison of Hereditary Hypertriglyceridemic (hHTG) and Brown-Norway (BN) Rats: Identification of Quantitative Trait Loci (QTLs) for the Insulin Resistance Syndrome526
Insulin Resistance in Adipocytes of SHR Rats532
Disproportionate Increase of Fatty Acid Binding Proteins in the Livers of Obese Diabetic Psammomys obesus536
Partial Characterization of Insulin Resistance in Adipose Tissue of Monosodium Glutamate-induced Obese Rats541
Biguanide Effects on Insulin Signaling546
Effect of the High-Fat Diet on the Calcium Channels in Rat Myocardium550
The Effect of Fasting and Vitamin E on Insulin Action in Obese Type 2 Diabetes Mellitus556
The Effect of Hyperlipidemia on Serum Fatty Acid Composition in Type 2 Diabetics561
High Lipid Levels in Slovak Rural Population: Consequence of Thyroid Dysfunction or Nutritional Status?568
Activity of Antioxidant Enzymes during Hyperglycemia and Hypoglycemia in Healthy Subjects575
Index of Contributors581

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