Lipids and Syndromes of Insulin Resistance: From Molecular Biology to Clinical Medicine

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New York, New York, U.S.A. 1997 paperback Very Good. No Dust Jacket Pages are clean and tight throughout. Cover is in very good condition. Previous owner's signature on FEP. ... Contains numerous tables and diagrams. There is creasing to the spine. *****PLEASE NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Editorial Reviews

Comprises 39 papers and 17 poster papers from the August-September 1996 symposium in Smolenice Castle, Slovak Republic. The papers are divided into six sections: animal models of the insulin resistance syndrome; molecular biology of syndromes of insulin resistance; role of lipids in diseases of insulin resistance; dietary fats in diseases of insulin resistance; energy balance, lipids, and obesity; and poster papers. Representative topics include diabetes and hypertension in rodent models; progress in determining the genes for hypertension, insulin resistance, and dyslipidemia; fat substitutes and energy balance; and the effect of fasting and vitamin E on insulin action in obese type 2 diabetes mellitus. No subject index. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

Table of Contents

Preface xi
Keynote Address: Progress in Population Analyses of the Insulin Resistance Syndrome 1
Part I. Animal Models of the Insulin Resistance Syndrome
Hypertension and the Insulin Resistance Syndrome of Rats: Are They Related? 13
Obesity Genes and Insulin Resistance Syndrome 35
Development of Obesity and Insulin Resistance in the Israeli Sand Rat (Psammomys obesus): Does Leptin Play a Role? 50
Diabetes and Hypertension in Rodent Models 64
Insulin Resistance Syndrome in Mice Deficient in Insulin Receptor Substrate-1 85
WOK.1W Rats: A Potential Animal Model of the Insulin Resistance Syndrome 94
Part II. Molecular Biology of Syndromes of Insulin Resistance
Lipid Transport Genes and Their Relation to the Syndrome of Insulin Resistance 100
Progress in Determining the Genes for Hypertension, Insulin Resistance, and Dyslipidemia 110
Hyperinsulinemia and Sympathoadrenal System Activity in the Rat 118
Is a Mutation of the [beta subscript 3]-Adrenergic Receptor Gene Related to Non-Insulin-dependent Diabetes Mellitus and Juvenile Hypertension in the Czech Population? 135
Glucose Transport and Insulin Signaling in Rat Muscle and Adipose Tissue: Effect of Lipid Availability 144
Cafestol (a Coffee Lipid) Decreases Uptake of Low-Density Lipoprotein (LDL) in Human Skin Fibroblasts and Liver Cells 158
High Fructose Feeding Enhances Erythrocyte Carbonic Anhydrase 1 mRNA Levels in Rat 163
Pharmacological Treatment and Mechanisms of Insulin Resistance: Impact on Vascular Smooth Muscle Cells, Blood Pressure, and Lipids 170
Part III. Role of Lipids in Diseases of Insulin Resistance
Fatty Acid Regulation of Gene Expression: Its Role in Fuel Partitioning and Insulin Resistance 178
Impact of Dietary Fatty Acid Composition on Insulin Action at the Nucleus 188
Molecular and Cellular Determinants of Triglyceride Availability 200
Dietary Fatty Acids, Insulin Resistance, and Diabetes 215
Lipid Abnormalities in Muscle of Insulin-resistant Rodents: The Malonyl CoA Hypothesis 221
Pharmacological Strategies for Reduction of Lipid Availability 231
Effect of Oral Antidiabetics and Insulin on Lipids and Coronary Heart Disease in Non-Insulin-dependent Diabetes Mellitus 246
Relationships between Fatty Acid Composition and Insulin-induced Oxidizability of Low-Density Lipoproteins in Healthy Men 269
Small Dense Low-Density Lipoprotein (LDL) in Non-Insulin-dependent Diabetes Mellitus (NIDDM): Impact of Hypertriglyceridemia 279
Part IV. Dietary Fats in Diseases of Insulin Resistance
Does Dietary Fat Influence Insulin Action? 287
Monounsaturated and Marine [omega]-3 Fatty Acids in NIDDM Patients 302
Omega-3 and Omega-6 Fatty Acids in the Insulin Resistance Syndrome: Lipid and Lipoprotein Metabolism and Atherosclerosis 310
Omega-6/Omega-3 Fatty Acid Ratio and Trans Fatty Acids in Non-Insulindependent Diabetes Mellitus 327
Dietary Fats and Hypertension: Focus on Fish Oil 339
Postprandial Triglyceride High Response and the Metabolic Syndrome 353
Evaluation of an Omega-3 Fatty Acid Supplement in Diabetics with Microalbuminuria 369
Paleodiet and Its Relation to Atherosclerosis 382
Part V. Energy Balance, Lipids, and Obesity
Passive Overconsumption: Fat Intake and Short-Term Energy Balance 392
Dietary Fats and Thermogenesis 408
Fat Metabolism in the Predisposition to Obesity 417
Fat and Energy Balance 431
Recent Advances in the Pharmacological Control of Energy Balance and Body Weight 449
Fat Substitutes and Energy Balance 461
Nonesterified Fatty Acid Regulation of Lipid and Glucose Oxidation in the Obese 476
Part VI. Poster Papers
Nuclear All-trans Retinoic Acid Receptors in Liver of Rats with Diet-induced Insulin Resistance 480
Diet-induced Insulin Resistance Is Associated with Decreased Activity of Type I Iodothyronine 5'-Deiodinase in Rat Liver 485
Insulin and Catecholamines Act at Different Stages of Rat Liver Regeneration 489
Fatty Acid Composition in Fractions of Structural and Storage Lipids in Liver and Skeletal Muscle of Hereditary Hypertriglyceridemic Rats 494
Increased Adipose Tissue Lipolysis in a Hypertriglyceridemic Rat Line 510
Structural Changes in the Aorta of the Hereditary Hypertriglyceridemic Rat 514
Increased Lipoprotein Oxidability and Aortic Lipid Peroxidation in an Experimental Model of Insulin Resistance Syndrome 521
Phenotype and Genotype Comparison of Hereditary Hypertriglyceridemic (hHTG) and Brown-Norway (BN) Rats: Identification of Quantitative Trait Loci (QTLs) for the Insulin Resistance Syndrome 526
Insulin Resistance in Adipocytes of SHR Rats 532
Disproportionate Increase of Fatty Acid Binding Proteins in the Livers of Obese Diabetic Psammomys obesus 536
Partial Characterization of Insulin Resistance in Adipose Tissue of Monosodium Glutamate-induced Obese Rats 541
Biguanide Effects on Insulin Signaling 546
Effect of the High-Fat Diet on the Calcium Channels in Rat Myocardium 550
The Effect of Fasting and Vitamin E on Insulin Action in Obese Type 2 Diabetes Mellitus 556
The Effect of Hyperlipidemia on Serum Fatty Acid Composition in Type 2 Diabetics 561
High Lipid Levels in Slovak Rural Population: Consequence of Thyroid Dysfunction or Nutritional Status? 568
Activity of Antioxidant Enzymes during Hyperglycemia and Hypoglycemia in Healthy Subjects 575
Index of Contributors 581
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