Living Without Oxygen: Closed and Open Systems in Hypoxia Tolerance

Overview


Innumerable clinical problems have as their basis some derangement in oxygen-dependent metabolism. To explore mechanisms of adjusting to oxygen limitation, Living without Oxygen presents a bestiary of exotic anaerobes that illuminate elements of metabolic biochemistry only dimly seen in studies using standard experimental animals. With their exaggerated anaerobic capabilities, Hochachka's diving mammals, airbreathing fishes, and hypoxia-adapted lower vertebrates allow a detailed assessment of what can and what ...
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Overview


Innumerable clinical problems have as their basis some derangement in oxygen-dependent metabolism. To explore mechanisms of adjusting to oxygen limitation, Living without Oxygen presents a bestiary of exotic anaerobes that illuminate elements of metabolic biochemistry only dimly seen in studies using standard experimental animals. With their exaggerated anaerobic capabilities, Hochachka's diving mammals, airbreathing fishes, and hypoxia-adapted lower vertebrates allow a detailed assessment of what can and what cannot be adjusted in the process of extending hypoxia tolerance. The book places the enzymatic and biochemical machinery firmly in the biological context and assumes only a modest familiarity with bioenergetics and metabolic biochemistry. The author's clear prose should make this technical presentation pleasantly unintimidating for any physiologist, biochemist, or clinical investigator. The insights of his unique approach make Living without Oxygen essential reading.
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Product Details

  • ISBN-13: 9780674498259
  • Publisher: Harvard
  • Publication date: 10/1/2013

Meet the Author

Peter W. Hochachka is Professor of Zoology, University of British Columbia
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Table of Contents

1. Anaerobic Metabolism: What Can and What Cannot Change

2. Helminths and the Usefulness of Carbon Dioxide

3. Coupled Glucose and Amino Acid Catabolism in Bivalve Molluscs

4. Coupled Glucose and Arginine Metabolism in Cephalopods

5. Key Elements of Anaerobic Glycolyis

6. Integrating Aerobic and Anaerobic Glycolysis

7. Integrative Mechanisms in Hypoxia-Adapted Fish

8. Air-Breathing Fish

9. Diving Marine Mammals

Epilogue

Index

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