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Long Shot: Vaccines for National Defense [NOOK Book]

Overview

Despite large-scale government demand for new vaccines in the past decade, few have materialized. Vaccine innovation has been falling since World War II. Hoyt’s timely investigation asks why, and teaches lessons for our efforts to rebuild biodefense capabilities when the financial payback for a vaccine is low but the social returns are high.
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Long Shot: Vaccines for National Defense

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Overview

Despite large-scale government demand for new vaccines in the past decade, few have materialized. Vaccine innovation has been falling since World War II. Hoyt’s timely investigation asks why, and teaches lessons for our efforts to rebuild biodefense capabilities when the financial payback for a vaccine is low but the social returns are high.
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Editorial Reviews

Choice

The history of vaccine development records periods of pronounced and of minimum productivity. The latter, according to Hoyt, describes the current development status and represents a danger to both civilian and military needs, most particularly to national defense objectives...Considering the magnitude of the problems, Hoyt's suggestions are well presented and reasonable and reflect an acute awareness of overall issues and concerns.
— R. S. Kowalczyk

David R. Franz
I've had the good fortune to know past leaders in vaccine development. I have also observed the present model from an orchestra seat since the mid-80s. The technology is now a given. Long Shot challenges us to find the leadership and the will to rediscover the way ahead for orphan medical countermeasures.
John Ellis Van Courtland Moon
At a time of continuing concern regarding bioterrorism and emerging diseases, the development of new vaccines is essential. Long Shot, an original, thoroughly documented and persuasive work utilizes extensive data from economics, science and organizational politics to demonstrate that the current failure of vaccine innovation presents a threat that U.S. policy makers ignore at their peril.
Choice - R. S. Kowalczyk
The history of vaccine development records periods of pronounced and of minimum productivity. The latter, according to Hoyt, describes the current development status and represents a danger to both civilian and military needs, most particularly to national defense objectives...Considering the magnitude of the problems, Hoyt's suggestions are well presented and reasonable and reflect an acute awareness of overall issues and concerns.
John Ellis van Courtland Moon
At a time of continuing concern regarding bioterrorism and emerging diseases, the development of new vaccines is essential. Long Shot, an original, thoroughly documented and persuasive work utilizes extensive data from economics, science and organizational politics to demonstrate that the current failure of vaccine innovation presents a threat that U.S. policy makers ignore at their peril.
Library Journal
Biological warfare remains a threat despite the billion dollars the U.S. government has poured over the last 20 years into prevention efforts, which have produced no new anthrax—and not many other—vaccines. Hoyt (medicine, Dartmouth) examines the importance of vaccine innovation for both national security and public health. She argues that whereas organizational processes were crucial for the dramatic World War II and postwar vaccine successes, post-9/11 industry responses to government funding were strong but lacked the necessary national coordination. Regulations that further increase cost and risk and limit international collaboration are major disincentives. Pharmaceutical companies are increasingly leaving the vaccine business, and small biotech firms lack the infrastructure for later-stage vaccine development and manufacturing. VERDICT Hoyt covers a much broader scope than her subtitle indicates. Innovations in research and development and the importance of vaccines to public health—second only to clean water—are vital issues and well addressed. Recommended for readers interested in this subject, particularly those with a medical, business, or national defense bent. All citizens need to know more about these subjects.—Mary Chitty, Cambridge Healthtech Lib., Needham, MA
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Product Details

  • ISBN-13: 9780674063150
  • Publisher: Harvard University Press
  • Publication date: 1/2/2012
  • Sold by: Barnes & Noble
  • Format: eBook
  • File size: 5 MB

Meet the Author

Kendall Hoyt is Assistant Professor, Department of Medicine, Dartmouth Medical School and Lecturer, Thayer School of Engineering, Dartmouth College.
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Table of Contents

Introduction 1

1 Disease, Security, and Vaccines 11

2 Historical Patterns of Vaccine Innovation 32

3 Vaccine Development during World War II 49

4 Wartime Legacies 81

5 The End of an Era 110

6 Biodefense in the Twenty-First Century 142

7 The Search for Sustainable Solutions 160

Appendices

Vaccine License Data, 1903-1999 180

Developmental History of Vaccines Licensed in the United States, 1903-1999 230

Military Contributions to Licenses Representing Innovative Activity 244

Notes 251

Acknowledgments 287

Index 289

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