Lung Cancer: Principles and Practice / Edition 1

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The Second Edition of Lung Cancer: Principles and Practice reflects the past four years' progress in prevention, screening, detection of early disease, and treatment. With contributions from surgeons, radiation oncologists, medical oncologists, pulmonologists, and basic scientists, this volume is the most comprehensive, current reference available on lung cancer.
This edition includes new findings on the molecular genetics and biology of lung cancer, updates on lung cancer immunology and gene therapy, and current concepts on genetic susceptibility. Greater emphasis is placed on prevention and screening for early disease. This edition also examines new cytotoxic agents and their interactions with radiation therapy.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

With contributions from clinicians in all relevant disciplines (surgery, radiation, oncology, medical oncology, pathology, and pulmonology), this second edition provides a comprehensive reference for any individual interested in lung cancer. Sections cover general concepts; molecular genetics; host-tumor interactions; basics of therapeutics; experimental models of lung cancer; etiology, epidemiology, screening, early detection, and prevention; pathology; clinical presentation, diagnosis, staging, and prognosis; surgery; radiation therapy; chemotherapy; treatment of small cell lung cancer; palliation and special considerations; and statistics and trial design. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780397513611
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 1/28/1996
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 982
  • Product dimensions: 8.79 (w) x 11.29 (h) x 1.88 (d)

Table of Contents

Contributing Authors
Pt. I Biology of Lung Cancer 1
1 General Concepts of Molecular Biology Related to Lung Cancer 5
2 Overview of Cell Cycle and Apoptosis 67
3 Cigarette Smoke Damage to DNA and Other Biomolecules 82
4 RAS and ERBB 2 89
5 The Role of MYC, JUN, and FOS Oncogenes 98
6 P53 120
7 RB1 and RB2 133
8 The Role of the FHIT Gene in the Pathogenesis of Lung Cancer 156
9 Telomerase in Lung Cancer 170
10 Growth Factors 181
11 Current Concepts of Angiogenesis Related to Primary Lung Cancer 199
12 Radiation Biology 213
13 Treatment-Related Lung Damage 247
14 Chemotherapy 270
15 Chemotherapy-Radiation Interaction 284
16 Immunology of Lung Cancer 304
17 Gene Therapy 318
18 Initiation of Cell Cultures from Lung Tumor Biopsies 337
19 Animal Models for Studying Lung Cancer and Evaluating Novel Intervention Strategies 347
Pt. II Etiology/Epidemiology/Screening/Early Detection/Prevention 365
20 Etiology and Epidemiology of Lung Cancer 367
21 Genetic Susceptibility to Lung Cancer 389
22 Early Diagnosis and Intervention in Lung Cancer: Clinical Studies 398
23 Molecular and Cytologic Techniques of Early Detection 407
24 The Use of Light for the Early Detection and Treatment of Lung Cancer 425
25 Chemoprevention: Scientific Rationale and Clinical Studies 438
Pt. III Pathology 451
26 Classification, Histology, Cytology, and Electron Microscopy 453
27 Techniques and Applications of Tissue Microdissection 496
28 Genomic Imbalances in Lung Cancer 502
Pt. IV Clinical Presentation, Diagnosis, Staging, and Prognosis 519
29 Clinical Presentation 521
30 Imaging 535
31 Tissue Procurement: Bronchoscopic Techniques 579
32 International Staging System for Lung Cancer 591
33 Clinical and Molecular Prognostic Factors and Models for Non-Small Cell Lung Cancer 602
34 Staging and Prognostic Factors for Small Cell Lung Cancer 612
35 Surgical Staging of the Mediastinum 628
Pt. V Surgery 647
36 Medical Evaluation and Management of the Lung Cancer Patient Prior to Surgery, Radiation, or Chemotherapy 649
37 Surgical Therapy of Stage I and Non-T3NO Stage II Non-Small Cell Lung Cancer 682
38 Extended Resections for Locally Advanced Non-Small Cell Lung Cancer 694
39 Chest Wall Involvement Including Pancoast Tumors 716
40 Surgical Management of Second Primary and Metastatic Lung Cancer 730
41 Complications of Surgery 742
42 Surgery and Chemotherapy 769
43 Postoperative Irradiation in Non-Small Cell Lung Cancer 778
44 Induction Therapy for Locally Advanced Non-Small Cell Lung Cancer 798
Pt. VI Radiation Therapy 821
45 Radiotherapy for Locally Advanced Lung Cancer: An Overview 823
46 Resectable Non-Small Cell Lung Cancer in the Medically Inoperable Patient: Curative Management with Radiation Therapy 829
47 Altered Fractionation Schedules for Lung Cancer 843
48 Three-Dimensional Radiation Therapy 853
49 Endobronchial and Interstitial Brachytherapy 867
Pt. VII Chemotherapy 887
50 Chemotherapy for Advanced Non-Small Cell Lung Cancer 889
51 Second-Line Chemotherapy for Non-Small Cell Lung Cancer 903
52 Combined Modality Treatment for Locally Advanced, Unresectable Non-Small Cell Lung Cancer 910
Pt. VIII Treatment of Small Cell Lung Cancer 921
53 Chemotherapy for Small Cell Lung Cancer 923
54 Multimodality Therapy for Limited-Stage Small Cell Lung Cancer: Combining Chemotherapy and Thoracic Irradiation 940
55 Surgical Management of Small Cell Lung Cancer 967
56 Prophylactic Cranial Irradiation in Small Cell Lung Cancer 981
Pt. IX Palliation and Special Considerations 993
57 Palliative Chemotherapy 995
58 Palliative Radiotherapy 1006
59 Malignant Pleural Effusion 1027
60 Malignant Pericardial Effusion 1038
61 Management of Malignant Airway Obstruction 1047
62 Superior Vena Cava Syndrome: Surgery and Stents 1056
63 Treatment of Non-Small Cell Lung Cancer in the Elderly Patient 1071
64 Treatment of Small Cell Lung Cancer in the Elderly Patient 1081
65 Cost Effectiveness and Lung Cancer 1092
Pt. X Statistics and Trial Design 1105
66 Statistics and Trial Design 1107
Subject Index 1117
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