Lupus: Molecular and Cellular Pathogenesis / Edition 1

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Overview

Leading basic and clinical investigators from around the world summari ze the most recent research on the molecular and cellular origins of l upus. Their cutting-edge articles review the mechanisms underlying abn ormal immunity and introduce the powerful new concept that a disorder of multiple genes underlies the abnormal immune response, leading dire ctly to the development of lupus. This pathophysiology is shown to inv olve a wide variety of cell types, including T cells, B cells, natural killer cells, macrophages/monocytes, and endothelial cells. Over time , the resulting long-term inflammation causes irreversible cell destru ction and, ultimately, organ failure. Lupus: Molecular and Cellular Pa thogenesis is a masterful new synthesis of all the new knowledge emerg ing today about lupus. Its new perspectives will sharpen the focus of research and ultimately lead to better and more effective treatment.

The book contains black-and-white illustrations.

Forty chapters by leading researchers capture the breadth and depth of the basic investigations underway today into the cellular and molecular origins of lupus. These cutting-edge articles review the current directions of lupus research with the goal of setting the stage for a working hypothesis about its causes that will sharpen the research focus by elucidating those avenues that are likely to be most productive over the next five years and permit more efficient use of finite resources. This comprehensive and insightful volume lays the foundation for targeted research that will ultimately solve the lupus enigma.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: It has long been accepted that lupus (systemic lupus erythematosus) has the hallmarks of an autoimmune disease. As the knowledge base regarding this disease has broadened, factors relating to genotype and possible external triggers have become better appreciated.
Purpose: This volume represents a comprehensive review of current information on lupus.
Audience: The intended audience is anyone who works in the field of lupus.
Features: Basic concepts of autoimmunity are covered as they relate to tissue damage, disease pathology, and many issues relating to host responses. Each is accompanied by a detailed bibliography and the volume as a whole has a useful index.
Assessment: This effort represents a comprehensive and authoritative coverage of work on lupus. It is up to date in that the latest developments in the field are provided (e.g., the role of Fas and apoptosis in disease management). All workers in this area will find this a valuable resource. It also represents a worthwhile addition to medical libraries.
Eugene A. Davidson
It has long been accepted that lupus (systemic lupus erythematosus) has the hallmarks of an autoimmune disease. As the knowledge base regarding this disease has broadened, factors relating to genotype and possible external triggers have become better appreciated. This volume represents a comprehensive review of current information on lupus. The intended audience is anyone who works in the field of lupus. Basic concepts of autoimmunity are covered as they relate to tissue damage, disease pathology, and many issues relating to host responses. Each is accompanied by a detailed bibliography and the volume as a whole has a useful index. This effort represents a comprehensive and authoritative coverage of work on lupus. It is up to date in that the latest developments in the field are provided (e.g., the role of Fas and apoptosis in disease management). All workers in this area will find this a valuable resource. It also represents a worthwhile addition to medical libraries.
Booknews
Summarizes recent research on the molecular and cellular origins of lupus, reviewing mechanisms underlying abnormal immunity and introducing the powerful new concept that a disorder of multiple genes underlies the abnormal immune response in lupus. This pathophysiology is shown to involve a wide variety of cell types and an overproduction of pathologic autoantibodies, producing a destructive inflammatory response. Explains new concepts of signal transduction, drug-induced lupus, adhesion molecules, and nitric oxide, and reviews T- and B-cell function abnormalities. Of interest to immunologists, rheumatologists, pathologists, and dermatologists. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
"This effort represents a comprehensive and authoritative coverage of work on lupus. It is up to date in that the latest developments in the field are provided (e.g., the role of Fas and apoptosis in disease management). All workers in this area will find this a valuable resource. It also represents a worthwhile addition to medical libraries..." -4 Stars, Doody's Health Sciences Book Review Journal

"Firstly, the references quoted in the various chapters are well poised, with a mix of historical ones and very recent ones. Secondly, the authors were asked to keep in mind four issues while writing: their working hypothesis, the relationship between the hypothesis and the advancement of understanding of lupus pathogenesis, how novel information allows new insights in the field and where to direct research in the next 5 years...I strongly recommend reading this book. It has the major merit of presenting in a coordinated fashion many new findings on a disease that remains largely mysterious. This book has the potential to encourage cross-fertilization among researchers interested in the field of autoimmunity, and provides a valuable tool for newcomers to get a sense of the daunting problems that remain to be solved in order to better understand the regulation and dysregulation of the immune system." -Journal of Investigative Dermatology


3 Stars from Doody
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Product Details

  • ISBN-13: 9780896035560
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 5/4/1999
  • Series: Contemporary Immunology
  • Edition description: 1999
  • Edition number: 1
  • Pages: 709
  • Product dimensions: 10.00 (w) x 7.00 (h) x 1.56 (d)

Table of Contents

Foreword
Preface
List of Contributors
1 Lupus: The Clinical Entity 1
2 The Vascular Endothelium: A New Actor in The Pathogenesis of Vascular Injury in Systemic Lupus Erythematosus 13
3 Nitric Oxide in Systemic Lupus Erythematosus: Implications for Immunity and Inflammation 21
4 Molecular Mimicry, Altered Apoptosis, and Immunomodulation as Mechanisms of Viral Pathogenesis in Systemic Lupus Erythematosus 43
5 Clustering and Proteolytic Cleavage of Autoantigens in Surface Blebs of Apoptotic Cells: Implications for Pathogenesis of SLE 65
6 Immune Effects of Bacterial DNA and Their Possible Role in the Pathogenesis of Lupus 79
7 Genetics of Systemic Lupus Erythematosus 101
8 Genetic Insights into Murine Lupus 124
9 Murine Graft-vs-Host Disease: Relevance to Human Lupus Immunopathogenesis and Therapy 140
10 Lessons From Knockout and Transgenic Lupus-Prone Mice 152
11 B Cells in Systemic Lupus Erythematosus 167
12 Mechanisms of the Pathogenic Autoimmune Response in Lupus: From Mouse Models to Human Disease 181
13 T-Cell Autoimmunity in Lupus: Ignorance, Anergy, and Activation 202
14 T-, B-, and Natural Killer Cell Dysfunction in Murine Systemic Lupus Erythematosis Models 220
15 Mechanisms of T-Helper Cell Activation and Function in Systemic Lupus Erythematosus 231
16 A Genetic Mechanism Underlying Deficient Type I Protein Kinase A Activity in Systemic Lupus Erythematosus T Lymphocytes 257
17 Impaired DNA Methylation in Lupus T Cells 278
18 Impaired Non-Antigen-Specific T-Cell Cytolytic Activity in SLE 299
19 Natural Killer Cells and CD8[superscript +] T Cells in the Downregulation of Antibody Production in Healthy Subjects and SLE: A Role for Transforming Growth Factor-[beta] and Interleukin-2 312
20 Cytokines in the Immunopathogenesis of Lupus 321
21 Cytokine Gene Expression in Human Systemic Lupus Erythematosus 341
22 Balance Between Type 1 and Type 2 Cytokine-Secreting Cells: Impact on Disease Activity in Systemic Lupus Erythematosus 361
23 Autoantibodies as a Source of Peptides That Regulate Autoantibody Production 371
24 Autoantibodies to Intracellular Antigens in Systemic Lupus Erythematosus Patients That Bind and Penetrate Cells 389
25 Pathogenesis of Autoantibody Production and Glomerulonephritis in Pristane-Treated Mice: An Inducible Model of SLE 399
26 Anti-DNA Antibodies: Markers of the Pathogenesis of Systemic Lupus Erythematosus 417
27 The Anti-DNA Response in Lupus: Structure, Initiation, and Pathogenesis 429
28 Glomerular Binding Antibodies in Systemic Lupus Erythematosus 448
29 The Antiphospholipid Syndrome: Mechanisms of Autoantibody-Mediated Thrombosis 471
30 Autoimmune-Associated Congenital Heart Block: Bringing Bedside Challenges to the Bench 492
31 Role of Calreticulin Autoimmunity in the Pathogenesis of Photosensitive Cutaneous Lupus Erythematosus 514
32 Complement System and Systemic Lupus Erythematosus 529
33 Type One Complement Receptor and Human SLE 541
34 Fc[gamma] Receptor Polymorphisms: Insights into Pathogenesis 557
35 Immune Complexes and Autoantibodies to Clq 574
36 Lipids and Lupus: The Fats of the Matter 599
37 Immunosuppressive Agents: Biologic Effects In Vivo and In Vitro 612
38 Treatment of Systemic Lupus Erythematosus by Selective Inhibition of T-Cell Function 642
39 Targeting Costimulatory and Other Signaling Molecules in Murine Lupus 656
40 Management of Murine Lupus by Correction of Fas and Fas Ligand-Induced Apoptosis: Therapeutic Rationale and Strategies 671
Index 695
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