Lupus Nephritis / Edition 2

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Overview


The presence of severe nephritis is a serious adverse prognostic feature of systemic lupus erythematosus (SLE). The book summarises the remarkable amount of information that has been generated in the quest for relief of patients, mostly young women, who have the unfortunate circumstances of having developed severe lupus nephritis. Lupus Nephritis pulls together in one reference source the current knowledge regarding the inherited and immunologic abnormalities which have been identified in SLE with specific reference to the development of renal disease and the way in which these factors may impact upon the chronic care of these patients. This book is also an up-to-date resource regarding the diagnosis and management of a broad range of abnormalities which are encountered in the population with lupus nephritis. The pathology, the clinical findings and therapeutic knowledge are reviewed, with chapters on the special problems associated with dialysis and transplantation therapy, and pregnancy in the patient with lupus nephritis. Physicians and scientists have been wrestling with the issue of the most effective treatment of this serious, potentially catastrophic, clinical problem for half a century. We must now look to the next century for the advances which can take us one step beyond our present therapeutic strategies.

The book contains black-and-white illustrations.

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Product Details

  • ISBN-13: 9780199568055
  • Publisher: Oxford University Press, USA
  • Publication date: 12/1/2010
  • Series: Oxford Clinical Nephrology Series
  • Edition number: 2
  • Pages: 356
  • Product dimensions: 6.10 (w) x 9.10 (h) x 0.80 (d)

Meet the Author

Edmund J. Lewis, M.D. is the Muehrcke Family Professor of Nephrology at Rush University Medical Center. Much of his career has been devoted to the study of immunopathologic mechanisms of glomerular disease, particularly lupus nephritis. He was an active participant in the International Study of Kidney Disease in Children (ISKDC), and as a member of the Pathology Committee he co-authored the first World Health Organization Classification of lupus nephritis. This led him to organize the Collaborative Study Group, whose initial study of plasmapheresis in severe lupus nephritis led to many important observations regarding clinical and histologic features which determine response to therapy in this patient population. In 2007, Dr. Lewis received the Belding Scribner Award of the American Society of Nephrology "for outstanding contributions to nephrology in the area of clinical practice and patient care".

Professor Melvin M. Schwartz completed his M.D. at the University of Minnesota in 1967, before taking a Pathology Residency at the Mallory Institute of Pathology between 1968 and1971, and completing a Renal Pathology Fellowship, also at the Mallory Institute of Pathology, in 1973. He became Professor Pathology at Rush University Medical Center in1984.

Stephen M. Korbet graduated from Rush Medical College in 1979 and did his internship, residency and Fellowship training at Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois. He is board certified in Internal Medicine and Nephrology. Dr. Korbet has received many prestigious honors and awards. He holds the endowed chair of the "Lester and Muriel Anixter Professor of Nephrology" at Rush Medical College. He is also currently the Medical Director of Circle Medical Management Dialysis Facility in Chicago as well as the Division Chief of the Section of Nephrology, Rush University Medical Center. Chicago, IL He has also been actively involved in clinical research involving kidney disease and dialysis since 1986 until the present date.

Tak Mao Daniel Chan graduated from the University of Hong Kong in 1985, and received training in nephrology and internal medicine in Hong Kong and at the Guy's Hospital in London, U.K. He is a Fellow of the Royal Colleges of Physicians in U.K. He is currently Personal Chair and Yu Foundation Endowed Professor in Nephrology at the Department of Medicine, and the Associated Dean at the Li Ka Shing Faculty of Medicine, University of Hong Kong. He was President of the Asian Pacific Society of Nephrology from 2008 to 2010. He is an Executive Committee member of the Asian Society of Transplantation, and has previously served as President of the Hong Kong Society of Transplantation. He pioneered the use of mycophenolate mofetil in the treatment of severe lupus nephritis. In addition to the treatment and immuno-pathogenesis of lupus nephritis, his other research interests include viral hepatitis in patients with renal failure.

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Table of Contents

Contributors
Abbreviations
1 Autoantibodies and lupus nephritis 1
2 Nephritogenic properties of lupus autoantibodies 22
3 Nucleosomes and lupus nephritis 79
4 Understanding lupus nephritis: unraveling the pathogenesis through molecular approaches in murine models 103
5 The pathological classification of lupus nephritis 126
6 Clinical manifestations of lupus nephritis 159
7 The natural history and treatment of lupus nephritis 185
8 Membranous lupus glomerulonephritis 219
9 Renal vascular involvement in SLE 241
10 Pregnancy in women with lupus nephritis 262
11 End-stage renal disease in the patient with SLE 284
Index 305
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