Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic / Edition 1

Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic / Edition 1

by Sudhir Gupta
     
 

ISBN-10: 030647395X

ISBN-13: 9780306473951

Pub. Date: 10/28/2002

Publisher: Springer US

During the past five years major progress has been made in understanding the basic mechanisms of lymphocyte homeostasis and in the developmental relationship between different memory T subsets and their traffic patterns and functional significance. This volume highlights the current concepts of lymphocyte development, factors regulating lymphocyte trafficking and

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Overview

During the past five years major progress has been made in understanding the basic mechanisms of lymphocyte homeostasis and in the developmental relationship between different memory T subsets and their traffic patterns and functional significance. This volume highlights the current concepts of lymphocyte development, factors regulating lymphocyte trafficking and development, and specialized characteristics and functional properties of naive and memory subsets. This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented. Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans. Novel methods of visualization of immune cells and immune systems are reviewed in Section III. This includes tracking of dendritic cells in vivo, monitoring arterial smooth muscle-specific T cells in the inflamed vasculature, imaging of molecular migrations in immune synapses, and visualization of various immune cells in intact lymphoid tissues by two photon confocal imaging. This volume should be of interest to immunologists, molecular biologists, microbiologists, pathologists, academic physicians, cell bio

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Product Details

ISBN-13:
9780306473951
Publisher:
Springer US
Publication date:
10/28/2002
Series:
Advances in Experimental Medicine and Biology Series, #512
Edition description:
2002
Pages:
212
Product dimensions:
6.69(w) x 9.84(h) x (d)

Table of Contents

1Lymphocyte Development in Neonatal and Adult C-KIT-Deficient (C-KIT[superscript W/W]) Mice1
2Development of Antigen-Specific Helper T Cell Responses In Vivo: Antigen-Specific TH Cell Subsets11
3BCL-6 Uncouples B Lymphocyte Proliferation from Differentiation21
4The Role of VAV Proteins in B Cell Responses29
5Traffic Patterns of B Cells and Plasma Cells35
6Lymphocyte Traffice in Lymphoid Organ Neogenesis Differential Roles of LT[alpha] and LT[alpha][beta]43
7Regulation of Spleen White Pulp Structure and Function by Lymphotoxin49
8Enzymatic Control of Leukocyte Traficking: Role of VAP-157
9Homestatic Chemokines and the Targeting of Regional Immunity65
10Factors Regulating Naive T Cells Homeostasis73
11IL-7, The Thymus, and Naive T Cells81
12Neonates Support "Homeostatic" Proliferation91
13Self-Recognition and the Regulation of CD4+ T Cell Survival97
14TCR-Independent Proliferation and Differentiation of Human CD4[superscript +] Cell Subsets Induced by Cytokines107
15Regulation of Memory CD4 T Cells: Generation, Localization and Persistence113
16Some Properties of T Cells in Animals121
17Generation and Characterization of Memory CD4 T Cells129
18T Cell Proliferation, Differentiation, and Restoration in Lymphopenic Individuals: For Contributed Volumes135
19Migration of Primary and Memory CD8 T Cells141
20Cytokines and Memory-Phenotype CD8[superscript +] Cells147
21Antiviral Memory T Cell Responses: Correlation with Protective Immunity and Implication for Vaccine Development155
22Homeostatic Proliferation but not the Generation of Virus Specific Memory CD8 T Cells is Impaired in the Absence of IL-15 or IL-15R[alpha]165
23Irreversible Marking of Dendritic Cells In Vivo: For Contributed Volumes177
24Tracking Arterial Smooth Muscle Specific T Cells in the Inflamed Vasculature183
25Regulation of T Cell Migration Through Formation of Immunological Synapses: The Stop Signal Hypothesis191
26Two-Photon Imaging in Intact Lymphoid Tissue203
Index209

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