Lymphocyte Activation and Immune Regulation IX: Homeostasis and Lymphocyte Traffic / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $122.29
Usually ships in 1-2 business days
(Save 46%)
Other sellers (Hardcover)
  • All (6) from $122.29   
  • New (5) from $122.29   
  • Used (1) from $279.38   


During the past five years major progress has been made in understanding the basic mechanisms of lymphocyte homeostasis and in the developmental relationship between different memory T subsets and their traffic patterns and functional significance. This volume highlights the current concepts of lymphocyte development, factors regulating lymphocyte trafficking and development, and specialized characteristics and functional properties of naive and memory subsets. This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented. Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans. Novel methods of visualization of immune cells and immune systems are reviewed in Section III. This includes tracking of dendritic cells in vivo, monitoring arterial smooth muscle-specific T cells in the inflamed vasculature, imaging of molecular migrations in immune synapses, and visualization of various immune cells in intact lymphoid tissues by two photon confocal imaging. This volume should be of interest to immunologists, molecular biologists, microbiologists, pathologists, academic physicians, cell bio

Read More Show Less

Product Details

Table of Contents

1 Lymphocyte Development in Neonatal and Adult C-KIT-Deficient (C-KIT[superscript W/W]) Mice 1
2 Development of Antigen-Specific Helper T Cell Responses In Vivo: Antigen-Specific TH Cell Subsets 11
3 BCL-6 Uncouples B Lymphocyte Proliferation from Differentiation 21
4 The Role of VAV Proteins in B Cell Responses 29
5 Traffic Patterns of B Cells and Plasma Cells 35
6 Lymphocyte Traffice in Lymphoid Organ Neogenesis Differential Roles of LT[alpha] and LT[alpha][beta] 43
7 Regulation of Spleen White Pulp Structure and Function by Lymphotoxin 49
8 Enzymatic Control of Leukocyte Traficking: Role of VAP-1 57
9 Homestatic Chemokines and the Targeting of Regional Immunity 65
10 Factors Regulating Naive T Cells Homeostasis 73
11 IL-7, The Thymus, and Naive T Cells 81
12 Neonates Support "Homeostatic" Proliferation 91
13 Self-Recognition and the Regulation of CD4+ T Cell Survival 97
14 TCR-Independent Proliferation and Differentiation of Human CD4[superscript +] Cell Subsets Induced by Cytokines 107
15 Regulation of Memory CD4 T Cells: Generation, Localization and Persistence 113
16 Some Properties of T Cells in Animals 121
17 Generation and Characterization of Memory CD4 T Cells 129
18 T Cell Proliferation, Differentiation, and Restoration in Lymphopenic Individuals: For Contributed Volumes 135
19 Migration of Primary and Memory CD8 T Cells 141
20 Cytokines and Memory-Phenotype CD8[superscript +] Cells 147
21 Antiviral Memory T Cell Responses: Correlation with Protective Immunity and Implication for Vaccine Development 155
22 Homeostatic Proliferation but not the Generation of Virus Specific Memory CD8 T Cells is Impaired in the Absence of IL-15 or IL-15R[alpha] 165
23 Irreversible Marking of Dendritic Cells In Vivo: For Contributed Volumes 177
24 Tracking Arterial Smooth Muscle Specific T Cells in the Inflamed Vasculature 183
25 Regulation of T Cell Migration Through Formation of Immunological Synapses: The Stop Signal Hypothesis 191
26 Two-Photon Imaging in Intact Lymphoid Tissue 203
Index 209
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)