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During the past five years major progress has been made in understanding the basic mechanisms of lymphocyte homeostasis and in the developmental relationship between different memory T subsets and their traffic patterns and functional significance. This volume highlights the current concepts of lymphocyte development, factors regulating lymphocyte trafficking and development, and specialized characteristics and functional properties of naive and memory subsets.
This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented.
Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans.
Novel methods of visualization of immune cells and immune systems are reviewed in Section III. This includes tracking of dendritic cells in vivo, monitoring arterial smooth muscle-specific T cells in the inflamed vasculature, imaging of molecular migrations in immune synapses, and visualization of various immune cells in intact lymphoid tissues by two photon confocal imaging.
This volume should be of interest to immunologists, molecular biologists, microbiologists, pathologists, academic physicians, cell biologists, and scientists and clinicians interested in vaccine development.
|1||Lymphocyte Development in Neonatal and Adult C-KIT-Deficient (C-KIT[superscript W/W]) Mice||1|
|2||Development of Antigen-Specific Helper T Cell Responses In Vivo: Antigen-Specific TH Cell Subsets||11|
|3||BCL-6 Uncouples B Lymphocyte Proliferation from Differentiation||21|
|4||The Role of VAV Proteins in B Cell Responses||29|
|5||Traffic Patterns of B Cells and Plasma Cells||35|
|6||Lymphocyte Traffice in Lymphoid Organ Neogenesis Differential Roles of LT[alpha] and LT[alpha][beta]||43|
|7||Regulation of Spleen White Pulp Structure and Function by Lymphotoxin||49|
|8||Enzymatic Control of Leukocyte Traficking: Role of VAP-1||57|
|9||Homestatic Chemokines and the Targeting of Regional Immunity||65|
|10||Factors Regulating Naive T Cells Homeostasis||73|
|11||IL-7, The Thymus, and Naive T Cells||81|
|12||Neonates Support "Homeostatic" Proliferation||91|
|13||Self-Recognition and the Regulation of CD4+ T Cell Survival||97|
|14||TCR-Independent Proliferation and Differentiation of Human CD4[superscript +] Cell Subsets Induced by Cytokines||107|
|15||Regulation of Memory CD4 T Cells: Generation, Localization and Persistence||113|
|16||Some Properties of T Cells in Animals||121|
|17||Generation and Characterization of Memory CD4 T Cells||129|
|18||T Cell Proliferation, Differentiation, and Restoration in Lymphopenic Individuals: For Contributed Volumes||135|
|19||Migration of Primary and Memory CD8 T Cells||141|
|20||Cytokines and Memory-Phenotype CD8[superscript +] Cells||147|
|21||Antiviral Memory T Cell Responses: Correlation with Protective Immunity and Implication for Vaccine Development||155|
|22||Homeostatic Proliferation but not the Generation of Virus Specific Memory CD8 T Cells is Impaired in the Absence of IL-15 or IL-15R[alpha]||165|
|23||Irreversible Marking of Dendritic Cells In Vivo: For Contributed Volumes||177|
|24||Tracking Arterial Smooth Muscle Specific T Cells in the Inflamed Vasculature||183|
|25||Regulation of T Cell Migration Through Formation of Immunological Synapses: The Stop Signal Hypothesis||191|
|26||Two-Photon Imaging in Intact Lymphoid Tissue||203|