Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology / Edition 1

Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology / Edition 1

by Jose Luis Millan
     
 

ISBN-10: 3527310797

ISBN-13: 9783527310791

Pub. Date: 03/20/2006

Publisher: Wiley

A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers:

* The structure, regulation and expression of the AP genes
* The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes
* The

Overview

A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers:

* The structure, regulation and expression of the AP genes
* The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes
* The phenotypic abnormalities of the different AP knockout mice
* Our current understanding of the in vivo role of the AP isozymes.

The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.

Product Details

ISBN-13:
9783527310791
Publisher:
Wiley
Publication date:
03/20/2006
Pages:
337
Product dimensions:
6.87(w) x 9.69(h) x 0.85(d)

Table of Contents

PART I: GENE AND PROTEIN STRUCTURE
1 Gene Structure
2 Developmental Expression
3 Gene Regulation
4 Protein Structure and Functional Domains
5 Enzymatic Properties
6 Epitope Maps
PART II: IN VIVO FUNCTIONS
7 The In Vivo Role of TNAP
8 Knockout Mouse Models
PART III: AP EXPRESSION IN HEALTH AND DISEASE
9 APs as Physiological and Disease Markers
10 Neoplastic Expression of PLAP, GCAP, IAP (Regan, Nagao, Kasahara) and TNAP Isozymes
PART IV: USES OF APS IN INDUSTRY AND BIOTECHNOLOGY
11 Applications of Recombinant APs
12 Use of APs in Prodrug Converting Strategies
13 APs as Therapeutic Agents
14 APs in the Food Industry
15 Veterinary Uses of AP Determinations
16 Methodologies

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