Management of Chemical and Biological Samples for Screening Applications

Management of Chemical and Biological Samples for Screening Applications

by Mark Wigglesworth
     
 

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Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire field of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and

Overview

Filling an obvious gap in the scientific literature, this practice-oriented reference is the first to tie together the working knowledge of large screening centers in the pharmaceutical and biotechnological field. It spans the entire field of this emerging discipline, from compound acquisition to collection optimization for specific purposes, to technology and quality control. In so doing, it applies two decades of expertise gathered by several large pharmaceutical companies to current and future challenges in high-throughput screening. With its treatment of libraries of small molecules as well as biobanks containing biomolecules, microorganisms and tissue samples, this reference is universally applicable for any molecular scientist involved in a large screening program.

Editorial Reviews

From the Publisher
“In the same vein, the chapters on new and enabling technologies, as well as how best to approach the options for outsourcing samples serve to provide a complete overview of all aspects of this discipline and complete the overall picture for the reader.”  (ChemBioChem, 1 January 2013)

“The book is a useful tool for any sample management organization, and will be particularly helpful as a guide for both updating the already existing structures and for planning future infrastructures dedicated to sample management.”  (Annali, 2012)

Product Details

ISBN-13:
9783527328222
Publisher:
Wiley
Publication date:
05/22/2012
Pages:
432
Product dimensions:
6.90(w) x 9.70(h) x 1.00(d)

What People are saying about this

From the Publisher
“In the same vein, the chapters on new and enabling technologies, as well as how best to approach the options for outsourcing samples serve to provide a complete overview of all aspects of this discipline and complete the overall picture for the reader.” (ChemBioChem, 1 January 2013)

“The book is a useful tool for any sample management organization, and will be particularly helpful as a guide for both updating the already existing structures and for planning future infrastructures dedicated to sample management.” (Annali, 2012)

Meet the Author

Mark Wigglesworth manages the UK Lead Optimization area of Sample Management Technologies for GlaxoSmith-Kline. Over the past 10 years Mark has managed large and small compound stores, assay ready plate production and compound set provision, as well as interacting with many areas of drug discovery. Additionally, he has led several drug discovery programs and overseen multiple screening platforms providing structure activity relationship data within GlaxoSmithKline's screening organizations.

Now a freelance business consultant, Terry Wood retired in 2011 as the manager of the Liquid Store Centre of Emphasis at Pfizer's world-wide R&D department, based in Sandwich (UK). He has been involved in the high-throughput screening process for the whole of his 25 year career with Pfizer. This has given him a first hand and broad knowledge about the challenges and caveats of assay design, development and prosecution. His prime responsibility focused on the management of Pfizer's extensive compound file, using a range of automated systems for sample preparation, storage and delivery.

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