Manual of Clinical Psychopharmacology / Edition 4

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Psychopharmacology has changed the face of modern psychiatry. Yet it is rare to find in the literature such a deeply informative yet eminently practical manual on this complex subject. Here, three senior psychopharmacologists offer a unique clinical perspective and practical advice on applying psychotropic medications to the treatment of specific psychiatric conditions.

Clearly written in a collegial, narrative style for easy reading and comprehension, the fourth edition of this bestselling manual offers extensively updated chapters with new sections and summary tables for quick reference, including the latest information on antidepressants, antipsychotics, mood stabilizers, antianxiety agents, hypnotics, and stimulants.

This comprehensive clinical guide emphasizes practical advice—i.e., specific recommendations about dosing, titration, and combining medications—derived from the authors’ extensive clinical experience. It begins with general principles of psychopharmacological treatment, including advice on legal, ethical, and economic issues. Subsequent chapters cover past, current, and future treatments for all major classes of medications, including mechanisms of action and pharmacokinetics. It also features chapters on augmentation strategies for treatment resistant disorders, emergency room treatment, pharmacotherapy for substance use disorders, and special topics such as pregnancy and mental retardation, with a fascinating final chapter on herbals and dietary supplements.

With its liberal use of tables and illustrations, and dual appendices on medication strengths and costs and suggested readings, this up-to-date, practical manual will be warmlywelcomed by not only practitioners, but also students (including those in nursing and pharmacy) and psychopharmacology residents.

PsychPharm™, the handheld version of the Manual of Clinical Psychopharmacology, is now available for both Palm OS and PocketPC handhelds. It gives a unique clinical perspective and practical advice on applying psychotropic medications to the treatment of specific psychiatric conditions. And with Skyscape's patented smARTlink™ technology, PsychPharm™ can easily cross-index with other clinical and drug prescription products from Skyscape to provide a powerful and integrated source of clinical information that you can carry with you wherever you go!

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Howard M. Kravitz, DO, MPH (Rush University Medical Center)
Description: The fourth edition of this psychopharmacology resource informs readers about changes in current treatments and includes the authors' perspectives on the role of alternative and complementary remedies. Previous editions were published in 1986, 1991, and 1997.
Purpose: The authors' continued intention is "to provide a readable, up-to-date guide to clinical psychopharmacology" written in a "collegial, reader-friendly style." The book is intended to be a guide, and readers are referred to standard references and textbooks for further information. Although it may be difficult to conceptualize a 600-page book as only a "guide," a review of therapeutic advances in and broadening of indications for psychopharmacological approaches to treating mental illness should convince the reader of the increasing complexity and volume of information in this field. The authors, who are experienced researchers and practitioners, have blended evidence-based literature with their empirical wisdom to produce a coherent clinical guide.
Audience: Psychiatric practitioners are the target audience. The level of writing is accessible to less experienced clinicians (including junior psychiatric residents) and the breadth of coverage should appeal to those more experienced.
Features: The book consists of 13 chapters. The first two review general principles of psychopharmacological treatment and diagnosis and classification. The next six, the essence of the book, cover different classes of treatments (e.g., antidepressants, antipsychotics). There are separate chapters on augmentation strategies for treatment-resistant disorders, emergency room treatment, substance use disorders, and special situations (pregnancy, pediatrics, geriatrics, mental retardation, medical conditions). The last chapter is on herbals and dietary supplements. The bibliography at the end of each chapter indicates updating since the 1997 edition. Summary tables highlight key information on classes of psychotropics. Figures show chemical structures of various compounds. There are two appendixes, one on dose strengths and costs of antidepressants and antipsychotics and one on suggested readings for clinicians (Janicak et al.'s Principles and Practice of Psychopharmacotherapy now has a third edition) and for patients and families. Some text detail could have been eliminated from this updated edition, such as two paragraphs (and its chemical structure) on methaqualone, which is no longer available. Drugs still unavailable in the U.S., such as reboxetine (over three pages) and duloxetine also are covered. Surprisingly, there are no treatment algorithms.
Assessment: The ever-advancing and expanding field of psychopharmacology mandates frequent periodic updating, particularly of well-written clinical guides exemplified by this book. However, in today's information era, this can be done more expeditiously via electronic media. Because many clinicians now keep this information in their palm pilots, a PDA version should be considered.
Katherine A. Tracy
This third edition provides up-to-date information on drug therapies for psychiatric disorders to aid the clinician in making informed decisions regarding treatment selection as well as subsequent management. The authors present basic and practical information regarding psychiatric medications and provide current information regarding newer agents in a usable clinical guide. Information is derived from scientific literature and common clinical use. This is a useful manual for all practitioners of clinical psychopharmacology. In particular, it should be a valuable resource for medical students and psychiatric residents. Nurses and therapists who care for patients receiving psychotropic medications may also find it useful. An adequate number of tables and figures complement the text. References are current, but the text is sparsely referenced (as acknowledged by the authors). An extensive bibliography follows each chapter, and the appendixes include suggested reading lists for clinicians and for patients and their families. This third edition is a valuable, extremely readable resource for residents in training as well as those currently practicing psychopharmacology. Classes of psychotropic medications are reviewed, including recommendations on selection, dosing, and management of side effects. The authors will often highlight changes in treatment recommendations that have evolved since the earlier edition of 1991. Agents approved since the second edition are reviewed, such as nefazodone, venlafaxine, mirtazapine, risperidone, and olanzapine. Agents not yet approved or not approved for certain indications are also discussed, such as sertindole, quetiapine, gabapentin, andlamotragine. Chapters address varied topics: medicolegal issues, psychoeconomics, combination therapy, and special populations (pregnant women, children and adolescents, mentally retarded, geriatric , and others). This useful and practical reference replaces the earlier edition.
Updates the first edition of 1986 with added sections on new drugs, expanded sections on important agents, more detailed treatment strategies for various disorders and situations, and other updates with the latest information from the literature and the authors' clinical practice. Spiral binding. Annotation c. Book News, Inc., Portland, OR (
Doodys Health Sciences Book Review Journal
This third edition is a valuable, extremely readable resource for residents in training as well as those currently practicing psychopharmacology. Four stars
—Doody's Health Sciences Book Review Journal).

3 Stars from Doody
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Product Details

  • ISBN-13: 9780880488655
  • Publisher: American Psychiatric Publishing, Inc.
  • Publication date: 9/28/2002
  • Edition description: Fourth Edition
  • Edition number: 4
  • Pages: 700
  • Product dimensions: 5.40 (w) x 8.37 (h) x 1.50 (d)

Meet the Author

Alan F. Schatzberg, M.D., is Kenneth T. Norris, Jr., Professor and Chairman, Department of Psychiatry and Behavioral Sciences, at Stanford University School of Medicine in Stanford, California.

Jonathan O. Cole, M.D., is Professor of Psychiatry at Harvard Medical School in Boston; Senior Consultant to McLean Hospital in Belmont; and Psychiatric Training Consultant at St. Elizabeth’s Medical Center in Brighton, Massachusetts.

Charles DeBattista, D.M.H., M.D., is Assistant Professor and Chief of the Depression Clinic, Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California.

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Table of Contents

1 General principles of psychopharmacological treatment 1
2 Diagnosis and classification 13
3 Antidepressants 33
4 Antipsychotic drugs 149
5 Mood stabilizers 237
6 Antianxiety agents 313
7 Hypnotics 369
8 Stimulants 401
9 Augmentation strategies for treatment-resistant disorders 423
10 Emergency room treatment 463
11 Pharmacotherapy for substance use disorders 481
12 Pharmacotherapy in special situations 511
13 Herbals and dietary supplements 573
App Strengths and costs of antidepressant and antipsychotic drugs 591
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