Manual of Clinical Psychopharmacology / Edition 6

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Psychopharmacology has changed the face of modern psychiatry. Yet it is rare to find in the literature such a deeply informative yet eminently practical manual on this complex subject. Here, three senior psychopharmacologists offer a unique clinical perspective and practical advice on applying psychotropic medications to the treatment of specific psychiatric conditions.

Clearly written in a collegial, narrative style for easy reading and comprehension, the sixth edition of this bestselling manual offers extensively updated chapters with new sections and summary tables for quick reference, including the latest information on antidepressants, antipsychotics, mood stabilizers, antianxiety agents, hypnotics, and stimulants.

This comprehensive clinical guide emphasizes practical advice—i.e., specific recommendations about dosing, titration, and combining medications—derived from the authors’ extensive clinical experience. It begins with general principles of psychopharmacological treatment, including advice on legal, ethical, and economic issues. Subsequent chapters cover past, current, and future treatments for all major classes of medications, including mechanisms of action and pharmacokinetics. It also features chapters on augmentation strategies for treatment resistant disorders, emergency room treatment, pharmacotherapy for substance use disorders, and special topics such as pregnancy and mental retardation, with a fascinating final chapter on herbals and dietary supplements.

With its liberal use of tables and illustrations, and dual appendices on medication strengths and costs and suggested readings, this up-to-date, practical manual will be warmly welcomed by not only practitioners, but also students (including those in nursing and pharmacy) and psychopharmacology residents.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Raj Tummala, MD (Wyeth Pharmaceuticals)
Description: This guide to clinical psychopharmacology is an easy to read reference for clinicians treating psychiatric patients.
Purpose: The purpose is to provide a comprehensive, easy to use reference of psychopharmacology for practicing clinicians.
Audience: It is targeted at anyone dealing with psychotropics such as students, residents, clinicians, and psychopharmacologists.
Features: This practical review of clinical psychopharmacology covers all of the disease states and their respective treatments divided by class. With this edition, there is a reorganization of the chapters along with new summary tables that serve as nice, quick references. Information is also augmented with graphs and tables. Starting from general principles of psychopharmacology, the authors cover all of the classes of psychotropics. While most of the information is evidence-based, the inclusion of personal experience sets this book apart. The authors address difficult situations and give practical information on overcoming situations that we all see in clinical settings. Each drug has a brief history, indications, overdose, and, most importantly, dosage administration. The authors take into account the variance in patient populations and advise dosing based on this. Of special mention are the sections on augmentation strategies and pharmacotherapy in special situations. Another area of special interest for clinicians is covered in the chapter on herbals and dietary supplements. Each chapter also has an updated reference section.
Assessment: This is a useful and easy to read update that clinicians can use in daily practice as a quick reference. The information is presented in a practical, user-friendly format, differentiating the book from others in this category.
Katherine A. Tracy
This third edition provides up-to-date information on drug therapies for psychiatric disorders to aid the clinician in making informed decisions regarding treatment selection as well as subsequent management. The authors present basic and practical information regarding psychiatric medications and provide current information regarding newer agents in a usable clinical guide. Information is derived from scientific literature and common clinical use. This is a useful manual for all practitioners of clinical psychopharmacology. In particular, it should be a valuable resource for medical students and psychiatric residents. Nurses and therapists who care for patients receiving psychotropic medications may also find it useful. An adequate number of tables and figures complement the text. References are current, but the text is sparsely referenced (as acknowledged by the authors). An extensive bibliography follows each chapter, and the appendixes include suggested reading lists for clinicians and for patients and their families. This third edition is a valuable, extremely readable resource for residents in training as well as those currently practicing psychopharmacology. Classes of psychotropic medications are reviewed, including recommendations on selection, dosing, and management of side effects. The authors will often highlight changes in treatment recommendations that have evolved since the earlier edition of 1991. Agents approved since the second edition are reviewed, such as nefazodone, venlafaxine, mirtazapine, risperidone, and olanzapine. Agents not yet approved or not approved for certain indications are also discussed, such as sertindole, quetiapine, gabapentin, andlamotragine. Chapters address varied topics: medicolegal issues, psychoeconomics, combination therapy, and special populations (pregnant women, children and adolescents, mentally retarded, geriatric , and others). This useful and practical reference replaces the earlier edition.
Updates the first edition of 1986 with added sections on new drugs, expanded sections on important agents, more detailed treatment strategies for various disorders and situations, and other updates with the latest information from the literature and the authors' clinical practice. Spiral binding. Annotation c. Book News, Inc., Portland, OR (
Doodys Health Sciences Book Review Journal
This third edition is a valuable, extremely readable resource for residents in training as well as those currently practicing psychopharmacology. Four stars
—Doody's Health Sciences Book Review Journal).

3 Stars from Doody
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Product Details

  • ISBN-13: 9781585623174
  • Publisher: American Psychiatric Publishing, Incorporated
  • Publication date: 5/28/2007
  • Series: Manual of Clinical Psychopharmacology Ser.
  • Edition description: Sixth Edition
  • Edition number: 6
  • Pages: 723
  • Product dimensions: 5.50 (w) x 8.25 (h) x 1.25 (d)

Meet the Author

Alan F. Schatzberg, M.D., is Kenneth T. Norris, Jr., Professor and Chairman in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California.

Jonathan O. Cole, M.D., is Professor of Psychiatry at Harvard Medical School in Boston; Senior Consultant at McLean Hospital in Belmont; and Psychiatric Training Consultant at St. Elizabet&hacute;s Medical Center in Brighton, Massachusetts.

Charles DeBattista, D.M.H., M.D., is Associate Professor and Chief of Depression Clinic in the Department of Psychiatry and Behavioral Sciences at Stanford University School of Medicine in Stanford, California.

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Table of Contents

1 General principles of psychopharmacological treatment 1
2 Diagnosis and classification 13
3 Antidepressants 33
4 Antipsychotic drugs 149
5 Mood stabilizers 237
6 Antianxiety agents 313
7 Hypnotics 369
8 Stimulants 401
9 Augmentation strategies for treatment-resistant disorders 423
10 Emergency room treatment 463
11 Pharmacotherapy for substance use disorders 481
12 Pharmacotherapy in special situations 511
13 Herbals and dietary supplements 573
App Strengths and costs of antidepressant and antipsychotic drugs 591
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