Manual of Stroke Models in Rats

by Yanlin Wang-Fischer (Editor)

Overview

During the last few years, exciting new insights into mechanisms and treatment of stroke have been obtained from animal experiments. Hence, the use of animal models to induce stroke are of paramount importance as research tools. While a few articles on this topic have been published in select journals, until now there has not been a systematic tech

Product Details

ISBN-13:	9781498718332
Publisher:	CRC Press
Publication date:	08/06/2008
Sold by:	Barnes & Noble
Format:	eBook
Pages:	352
File size:	17 MB
Note:	This product may take a few minutes to download.

About the Author

Yanlin Wang-Fischer, M.D., Ph.D., is a neuropharmacologist. She has worked in the pharmaceutical industry and academic environment for many years. Dr. Wang-Fischer earned her bachelor’s degree and doctor of medicine at Hunan Medical University, Changsha, China. Following clinical fellowship training in cardiovascular and metabolic diseases at Hunan Medical University, where she became an attending physician, she earned her Ph.D. in 1994. She completed her postdoctoral fellowship training at the School of Medicine at Laval University and at Boston University. Dr. Wang-Fischer joined the Howard Hughes Medical Institute at Yale University, New Haven, Connecticut, in 2000. She has contributed to several projects related to animal models and surgeries and produced an instructional video on studies of animals in vivo for new trainees. In 2002, Dr. Wang-Fischer joined the team of neurological disorders at Johnson&Johnson PRD, Raritan, New Jersey. She led projects based on different animal models to discover new drugs for treatment of stroke and neurological diseases. In 2006, Dr. Wang-Fischer joined Palatin Technologies and oversees projects on nasal and cerebral drug delivery. She has developed a novel technique to quickly assess nasal tolerance. Dr. Wang-Fischer has published more than 40 scientific articles in prestigious medical journals. Her current interests include neurological, cardiovascular, metabolic, and inflammatory diseases, mainly concerned with physiology and pharmacology in vivo.

Table of Contents

Statistical Update of Stroke in America. Rationale for Using Ischemic Stroke Models. Animal Models of Ischemic Stroke: A Historical Survey. Anatomy and Cerebral Circulation of the Rat. Which Animal to Choose? Which Model to Use? Failure Is the Mother of Success: Why Neuroprotective Therapies That Work in Laboratories Fail in Clinical Trials. Anesthesia of Laboratory Rats.
General Principles of Microsurgery on Animals. Microsurgical Instruments for Stroke Studies. Postoperative Care. Surgery Procedure for Distal Middle Cerebral Artery Occlusion Model.
Surgical Models of Stroke Induced by Intraluminal Filament Implantation. Embolic Stroke Models. Photochemically Based Models of Focal Experimental Thrombotic Stroke in Rodents. Induction of Asphyxia Cardiac Arrest in a Rat as a Model of Global Cerebral Ischemia. Four-Vessel Occlusion Stroke Model in Rats. Brain Hemorrhage Models in Rodents. Endpoints for Stroke Studies. Tissue Staining Techniques for Stroke Studies. Protocol for Brain Vessel Corrosion Casting and Embedding. Magnetic Resonance Imaging in Stroke Study. Administration of Substances and Sampling. Study Design in Animal Models of Stroke. Common Biochemical and Physiological Parameters in Rats.