Marihuana and Medicine

Overview

Leading physicians and scientists from around the world critically examine the pharmacological and molecular basis of the therapeutic properties of marihuana and its active ingredient, THC. They detail the broad array of marihuana's effects on brain function, the immune system, male and female reproductive functions, and cardiac and pulmonary functions, as well as evaluate its clinical applications in psychiatry, glaucoma, pain management, cancer chemotherapy, and AIDS treatment. Their studies indicate that ...

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Overview

Leading physicians and scientists from around the world critically examine the pharmacological and molecular basis of the therapeutic properties of marihuana and its active ingredient, THC. They detail the broad array of marihuana's effects on brain function, the immune system, male and female reproductive functions, and cardiac and pulmonary functions, as well as evaluate its clinical applications in psychiatry, glaucoma, pain management, cancer chemotherapy, and AIDS treatment. Their studies indicate that marihuana persistently impairs the brain and reproductive function, and that marihuana smoke is more toxic and damaging to the lung than tobacco smoke. Marihuana and Medicine's reports of the latest findings on the pharmacological and molecular mechanisms of marihuana and of its clinical manifestations will be essential reading for physicians, psychiatrists, pharmacologists, health-care professionals, policy makers, public health officials, and attorneys.

The book contains black-and-white illustrations.

This book evolved from a conference of leading physicians from around the world to review the pharmacological and molecular basis of the therapeutic properties of marihuana and THC, and to evaluate their clinical applications. The book delivers the most up-to-date information on the pharmacokinetics and molecular mechanisms of cannabinoids, brain metabolism and tissue distribution, pharmacological and toxicological effects of cannabinoids, cannabinoids and the treatment of pain, cannabinoids and the nervous system, marihuana and glaucoma, and marihuana and AIDS management.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, D.O., M.A.(University of Illinois at Chicago College of Medicine)
Description: This is a comprehensive book covering the pharmacological, metabolic, and therapeutic properties of marijuana. Written and edited by researchers in the field, this is a valuable contribution to the field.
Purpose: The purpose is to report the latest findings on the pharmacological, pharmacodynamic, and molecular mechanisms of marijuana.
Audience: The intended audience, as stated by the editors, is clinicians, psychiatrists, pharmacologists, policy makers, healthcare workers, and attorneys.
Features: The book features 826 pages divided into 11 parts and 71 chapters, including an introduction, and an index section. Topics covered include an historical review, chemistry and pharmacokinetics, biochemistry and molecular mechanisms, pharmacology and physiopathology, reproductive function, treatment of pain, glaucoma, effects on the nervous system, marijuana and psychiatry, AIDS management, marijuana and medicine, public health, and public policy. The book ends with a useful index section.
Assessment: This is a valuable book with a focus on the molecular and clinical aspects of marijuana. It will be mainly used as a reference.
Booknews
Examines the pharmacological and molecular basis of the therapeutic properties of marihuana and its active ingredient, THC. Seventy-one chapters detail the broad array of marihuana's effects on brain function, the immune system, male and female reproductive functions, and cardiac and pulmonary functions. They also evaluate clinical applications in psychiatry, glaucoma, pain management, cancer chemotherapy, and AIDS treatment, and they describe the interaction of marihuana with anesthetics and other commonly used drugs. Key historical studies trace the scientific history of marihuana in medicine. Annotation c. by Book News, Inc., Portland, Or.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780896035935
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/28/1999
  • Edition description: 1999
  • Edition number: 1
  • Pages: 826
  • Product dimensions: 7.10 (w) x 10.00 (h) x 1.40 (d)

Table of Contents

Introduction: Marihuana and Medicine-A Historical Review. A Brief History of Four Millennia (BC 2000-AD 1974), Hélène Peters. The

Helsinki Symposium (1975), Gabriel G. Nahas and W. D. M. Paton. The Reims Symposium (1978), Gabriel G. Nahas, W. D. M. Paton, and D. J.

Harvey. Conflicting Reports on Marihuana and Health (1981-1982), A. S. Relman and C. Everett Koop. The Louisville Symposium of the

American Society for Pharmacology and Experimental Therapeutics (1982), Stig Agurell, William L. Dewey, and Robert E. Willete. The

Oxford Symposium "Marihuana '84", David J. Harvey, W. D. M. Paton and Gabriel G. Nahas. The Paris Symposium of the French "National

Academie de Medicine" (1992), Jacques Chirac, Henri Baruk, Paul Lechat, and Henri Baylon. The 1997 Medical Controversy over the

Legalization of Marihuana for Medicine in the United States, Jerome P. Kassirer, Gabriel G. Nahas, Kenneth Sutin, W. Manger, and G. Hyman. Part I. Chemistry and Pharmacokinetics. Cannabinoid Geometry and Biological Activity, RaphaelMechoulam, W. A. Devane, and R. Glaser. Absorption, Distribution, and Biotransformation of the Cannabinoids, David J. Harvey. Pharmacokinetics of THC in Inhaled and Oral Preparations, Marilyn Huestis. Pharmacokinetics and Mechanisms of Action of Analgesics in Clinical Pain, John E. Stambaugh.

D9-THC Hemisuccinate in Suppository Form as an Alternative to Oral and Smoked THC, Larry A. Walker, Ernest C. Harland, Allyson M. Best, and Mahmoud A. ElSohly. Composition and Stability of a Standard Marihuana Cigarette, Brian F. Thomas, Victor L. Parker, Lillian W. Caddell, Larry V. Jones, Surinder K.Sabharwal, Andy I. McDaniel, Alison R. Keimowitz, Nicole M. Scheffler, E. Dale Hart, John M. Mitchell, and Kenneth H. Davis, Jr..Study Design Considerations in Clinical Trials with Marihuana, Reese T. Jones. Part II. Biochemistry and Molecular Mechanisms. Effects of THC on Brain and Social Organization of Ants, Peter Waser. Studies of the Brain Cannabinoid System

Using Positron and Single-Photon Emission Tomography, S. John Gatley, Nora D. Volkow, and Alexandros Makriyannis. Cannabinoid Receptors and Their Ligands in Brain and Other Tissues, Roger G. Pertwee. Cannabinoid Interaction with Brain Reward Systems, Eliot L. Gardner. Dependence, Tolerance, and Alteration in Gene Expression, Noboru Hiroi. Cocaine and a Mechanism for Long-Term Changes in Gene Expression, Bruce T. Hope. Cannabonoids and the Cholinergic System, Edward F. Domino. Marihuana: Acute Effects on Human Memory, Loren L. Miller. Does THC Induce Aggression?: Suppression and Induction of Aggressive Reactions by Chronic and Acute

D9-Tetrahydrocannabinol Treatment in Laboratory Rats, Klaus A.Miczek. Part III. Pharmacology and Physiopathology. The Psychology and Physiologic Effects of Active Cannabinoids, Mario Perez-Reyes. Physiological and Pharmacological Interactions of Marihuana (THC) with Drugs and Anesthetics, Kenneth M. Sutin and Gabriel G. Nahas. Interactions of Marihuana and THC with Other Drugs: What We Don't, But Should, Know, Leo E. Hollister. Marihuana and the Lung, Donald P. Tashkin. Marihuana Smoking, a Possible Carcinogen or Cocarcinogen, George Hyman. Cardiovascular Effects of Marihuana and Cannabinoids, Renaud Trouve and Gabriel Nahas. The Immune Response and Marihuana, Harris Rosenkrantz. Marihuana and the Immune System, Guy A. Cabral. How to Design the Ideal Drug of the Future, Paul Janssen. Part IV. Marihuana and Reproductive Function. Cannabinoid Receptors in Sperm, Herbert Schuel, Michael C.

Chang, Lani J. Burkman, Robert P. Picone, AlexandrosMakriyannis, Arthur M. Zimmerman, and Selma Zimmerman. Effects of Cannabinoids on Spermatogenesis in Mice, Arthur M. Zimmerman, Selma Zimmerman, and A. Yesoda Raj. Effects of Marihuana Inhalation on Spermatogenesis of the Rat, Hosea F. S. Huang, Gabriel G. Nahas, and Wylie C. Hembree III. Changes in Human Spermatozoa Associated with High-Dose Marihuana Smoking, Wylie C. Hembree III, Gabriel G. Nahas, P. Zeidenberg, and Hosea F. S. Huang. Tolerance to the Reproductive Effects of D9-Tetrahydrocannabinol: Comparison of the Acute, Short-Term, and Chronic Drug Effects on Menstrual Cycle Hormones, Carol Grace Smith, Ramona G. Almirez, Pamela M. Sher, and Riccardo H. Asch. Marihuana Effects on Pituitary and Gonadal Hormones in Women, Jack H. Mendelson and Nancy K. Mello. Cannabinoid Ligand-Receptor Signaling During Early Pregnancy in the Mouse, Bibhash C. Paria, Sanjoy K. Das, and Sudhansu K. Dey. Effects of Cannabis on Fetal Development of Rodents, Harris Rosenkrantz. Prenatal Exposure to Cannabis and Fetal Development, David D. Cozens, Gabriel G. Nahas, and David Harvey. Maternal or Paternal Exposure to Cannabinoids

Affects Central Neurotransmitter Levels and Reproductive Function in Male Offspring, Susan L. Dalterio, Richard W. Steger, and Andrzej Bartke. Reproduction in Rhesus Monkeys Chronically Exposed to D9-Tetrahydrocannabinol, E. N. Sassenrath, L. F. Chapman, and G. P. Goo. The Effects of Maternal Marihuana Use During Pregnancy on Fetal Growth, Steven J. Parker and Barry S. Zuckerman. Part V. Cannabinoids in the Treatment of Pain. Central Mechanisms of Pain and Analgesia, Lars Terenius. Pharmacology of Chronic Pain, Andy Dray, Laszlo Urban, and Anthony Dickenson. Pharmacology of Chronic Pain, Andy Dray, Laszlo Urban, and Anthony Dickenson. Antipyretic Analgesic Drugs, Kay Brune. Dimethylheptyl-THC-11-oic Acid: A Nonpsychoactive Antiinflammatory Agent with a Cannabinoid Template Structure, Robert B. Zurier, Ronald G. Rossetti, Joan H. Lane, John M. Goldberg, Sheila A. Hunter, and Sumner H. Burstein. Analgesic

Properties of THC and Its Synthetic Derivatives, Aron H. Lichtman and Billy R. Martin. Barbiturate Potentiating, Temperature Reducing, Analgesic, and Behavioral Effects of Some Synthetic Tetrahydocannabinol Derivatives in Comparison with D9-Tetrahydrocannabinol, Peter G. Waser and Anne Martin. Hyperalgesia and Response Bias Following Chronic Marihuana Smoking, W. Crawford Clark. Levonantradol, B. Kenneth Koe. Nabilone: A Synthetic Cannabinoid of Medicinal Utility, Louis Lemberger. Clinical Experience of the Synthetic Cannabinoid Nabilone for Chronic Pain, William Notcutt, Mario Price, Patrick Blossfeldt, and Glen Chapman. Cannabinoids in the Treatment of Pain: An Overview, Michel Dubois, Gabriel Nahas, and Kenneth Sutin. Part VI. Marihuana and Glaucoma. Marihuana and Intraocular Pressure: Possible Mechanisms of Action, Keith Green. Marihuana and the Treatment of Glaucoma, Max Forbes. Part VII. Marihuana, Cannabinoids, and the Nervous System. Cannabinoids and the Control of Chemotherapy-Induced Nausea and Vomiting, Richard J. Gralla. Clinical and Experimental Reports of Marihuana and Cannabinoids in Spastic Disorders, Paul Consroe. Marihuana: Effects on Neuronal Excitability and Seizure Threshold, Elisabeth Gordon and Orrin Devinsky. Marihuana Use in Multiple Sclerosis, Gordon S. Francis. Recreational and Medicinal Uses of Marihuana in Latin America, F. Raúl Jerí. Part VIII. Marihuana and Psychiatry. The Neuropsychiatric Syndrome of D9-Tetrahydrocannabinol and Cannabis Intoxication in Naive Subjects: A Clinical and Polygraphic Study During Wakefulness and Sleep, C. A. Tassinari, G. Ambrosetto, M. R. Peraita-Adrado, and H. Gastaut. Cannabis and Psychiatric Syndrome, Peter Allebeck. Cannabis and Schizophrenia: An Overview of the Evidence to Date, Juan C. Negrete and Kathryn Gill. Detection of Cannabis in Victims of Violent Death in Skholm (1987-1994), Jovan Rajs and Anna Fugelstad. Part IX. Marihuana and AIDS Management. Pathogenesis of Malnutrition in HIV Infection, Donald P. Kotler. The Safety and Pharmacokinetics of Single-Agent and Combination Therapy with Megestrol Acetate and Dronabinol for the Treatment of HIV Wasting Syndrome, Joseph G. Timpone, David J. Wright, Ning Li, Merrill J. Egorin, Mary E. Enama, Jacqueline Mayers, Giorgio Galetto, and the DATRI 004 Study Group. Marihuana for AIDS Wasting: A Critique of the Data, William M. Bennett and Sandra S. Bennett. Part X. Marihuana and Medicine, Public Health, and Public Policy. Cannabis and Alcohol: The Green and the Red, Franz Rosenthal. The Distribution of Consumption of Alcohol and Marihuana, Gabriel Nahas, Renaud Trouvé, and Colette Latour. Drug Abuse and the Law: Prosecution or Persecution?, James A. Moss. Federal Regulations for the Prescription of Controlled Substances: Drug Enforcement Administration (DEA), John H. King. FDA Regulation of Prescription of Controlled Substances, Nicholas Reuter. The Swedish Addiction Epidemic in Global Perspective, Nils Bejerot and Jonas Hartelius. Part XI. General Conclusions. The Medical Use of Marihuana and THC in Perspective, Nicholas Pace, Henry Clay Frick, William Manger, George Hyman, and Gabriel Nahas. Receptor and Nonreceptor Membrane-Mediated Effects of THC and Cannabinoids, Gabriel G. Nahas, David Harvey, Kenneth Sutin, and Stig Agurell. Marihuana and Medicine: From Human to Molecular Physiology, Gabriel G. Nahas. Index.

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