Mass Spectrometry in Biology and Medicine / Edition 1

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Overview

Leading practitioners detail revolutionary new spectrometric techniques for the identification and covalent structural characterization of macromolecules, proteins, glycoconjugates, and nucleic acids. Based on the Fourth International Symposium on Mass Spectrometry in the Health and Life Sciences held in San Francisco in 1998, this invaluable book contains tested strategies for solving many significant biomedical research problems. The techniques use mass spectrometry, automated computer processing of spectral information, and gene, protein, and EST databases for genomic and proteomic correlations. Mass Spectrometry in Biology and Medicine offers a unique opportunity to explore and apply these new techniques of mass spectrometry that are revolutionizing the identification and structural characterization of proteins, carbohydrates, and nucleic acids.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This volume contains presentations from a recent symposium focused on new applications of mass spectrometry. The depth of utility of mass spectrometry has increased greatly with the advent of methods for studying macromolecules, utilizing very small amounts of material, and processing large data sets. A telling example is the use of this technique as a purity criterion for proteins produced by recombinant methods.
Purpose: The purpose is to provide an overview of mass spectrometry. This worthy objective has been met.
Audience: The audience for this book is broad, and includes investigators who should already have a background in mass spectrometry.
Features: In 27 chapters the editors provide a very useful overview of the application of mass spectrometric methods to a wide variety of biological problems. Examples include determination of purity, molecular weight, presence of posttranslational modifications (glycosylation, phosphorylation), ligand binding, sequencing of peptides, coupling of purification protocols (capillary electrophoresis, for example) and the use of tandem spectrometers.
Assessment: Investigators dealing with this range of problems will want to familiarize themselves with the potential offered by this technology. Although some experimental details are presented, this remains a specialist field; the reference citations are very limited but there is an adequate index.
Eugene A. Davidson
This volume contains presentations from a recent symposium focused on new applications of mass spectrometry. The depth of utility of mass spectrometry has increased greatly with the advent of methods for studying macromolecules, utilizing very small amounts of material, and processing large data sets. A telling example is the use of this technique as a purity criterion for proteins produced by recombinant methods. The purpose is to provide an overview of mass spectrometry. This worthy objective has been met. The audience for this book is broad, and includes investigators who should already have a background in mass spectrometry. In 27 chapters the editors provide a very useful overview of the application of mass spectrometric methods to a wide variety of biological problems. Examples include determination of purity, molecular weight, presence of posttranslational modifications (glycosylation, phosphorylation), ligand binding, sequencing of peptides, coupling of purification protocols (capillary electrophoresis, for example) and the use of tandem spectrometers. Investigators dealing with this range of problems will want to familiarize themselves with the potential offered by this technology. Although some experimental details are presented, this remains a specialist field; the reference citations are very limited but there is an adequate index.
Booknews
Proceedings of the 1998 symposium in which leading practitioners detailed revolutionary new spectrometric techniques for the identification and covalent structural characterization of macromolecules, proteins, glycoconjugates, and nucleic acids. Twenty- six contributions discuss key points including biological mass spectrometry; powerful mass spectrometric techniques; new data and protocols in protein biology, glycobiology, and nucleic acid research; reviews of 2-D gels, database interrogation, and protein posttranslational modifications; and extremely sensitive techniques for sequencing peptides and identifying proteins. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780896037991
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 9/14/1999
  • Edition description: 2000
  • Edition number: 1
  • Pages: 577
  • Product dimensions: 10.00 (w) x 7.00 (h) x 1.31 (d)

Table of Contents

A New Delayed Extraction MALDI-TOF MS-MS for Characterization of Protein Digests, Marvin Vestal, Peter Juhasz, Wade Hines, and Stephen Martin. Measurements of Protein Structure and Noncovalent Interactions by Time-of-Flight Mass Spectrometry With Orthogonal Ion Injection, A. N. Krutchinsky, I. V. Chernushevich, A. V. Loboda, W. Ens and K. G. Standing. Isotopic Amplification, H/D Exchange, and Other Mass Spectrometric Strategies for Characterization of Biomacromolecular Topology and Binding Sites, Alan G. Marshall, Mark R. Emmett, Michael A. Freitas, Christopher L. Hendrickson and Zhongqi Zhang, Probing the Nature of Amyloidogenic Proteins by Mass Spectrometry, Ewan J. Nettleton and Carol V. Robinson. Studying Noncovalent Small Molecule Interactions with Protein and RNA Targets by Mass Spectrometry, Joseph A. Loo, Venkataraman Thanabal and Houng-Yau Mei. Identification of Protein-Protein Interfaces by Amide Proton Exchange Coupled to MALDI-TOF Mass Spectrometry, Jeffrey G. Mandell, Arnold M. Falick and Elizabeth A. Komives. Electron Capture Dissociation Produces Many More Protein Backbone Cleavages Than Collisional and IR Excitation, Roman A. Zubarev, Einar K. Fridriksson, David M. Horn, Neil L. Kelleher, Nathan A. Kruger, Mark A. Lewis, Barry K. Carpenter and Fred W. McLafferty. Protein Micro-Characterization by Mass Spectrometry: Sample Handling and Data Flow, Paul Tempst, Hediye Erdjument-Bromage, Matthew C. Posewitz, Scott Geromanos, Gordon Freckleton, Anita Grewal, Lynne Lacomis, Mary Lui and John Philip. Towards an Integrated Analytical Technology for the Generation of Multidimensional Protein Expression Maps, Paul A. Haynes, David R. Goodlett, Steven P. Gygi, Julian D. Watts, Daniel Figeys and Reudi Aebersold. Sequencing the Primordial Soup, Jeffrey Shabanowitz, Robert E. Settlage, Jarrod A. Marto, Robert E. Christian, Forest M. White, Paul S. Russo, Susan E. Martin and Donald F. Hunt. Coaxial Nanospray Coupled with a Hybrid Quadrupole/Time-of-Flight Tandem Mass Spectrometer for Proteome Studies, M. A. Moseley. Life Without Databases: De Novo Sequencing of Small Gene Products and Complete Characterization of Posttranslational Modifications, Roland S. Annan, Michael J. Huddleston, Dean E. McNulty and Steven A. Carr. Investigation of Intact Subunit Polypeptide Composition of the 20S Proteasome Complex from Rat Liver Using Mass Spectrometry, Lan Huang, C. C. Wang and A. L. Burlingame. Deciphering Functionally Important Multiprotein Complexes by Mass Spectrometry, Andrej Shevchenko and Matthias Mann. Investigation of Apoptosis-Involved Processes by Mass Spectrometric Identification of the Apoptosis-Associated Proteins in IgM-Induced Burkitt Lymphoma Cells, Eva-Christina Müller, Brigitte Wittmann-Liebold and Albrecht Otto. IR-MALDI - Softer Ionization in MALDI-MS for Studies of Labile Macromolecules, R. Cramer and A. L. Burlingame. Identification of in-vivo Phosphorylation Sites with Mass Spectrometry, Xiaolong Zhang, Christopher J. Herring and Jun Qin. Determination of Enzyme Mechanisms by Stopped-Flow Electrospray Mass Spectrometry, Frank B. Simpson and Dexter B. Northrop. Glycosylation of Proteins -A Major Challenge in Mass Spectrometry and Proteomics, Gerald W. Hart, Robert N. Cole, Lisa K. Kreppel, C. Shane Arnold, Frank I. Comer, Sai Iyer, Xiaogang Cheng, Jill Carroll and Glendon J. Parker. Site-specific Characterization of the N-linked Glycans of Murine PrPSc Using Advanced Methods of Electrospray Mass Spectrometry, Elaine Stimson, James Hope, Angela Chong and Alma L. Burlingame. Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry of N-Linked Carbohydrates and Related Compounds, David J. Harvey, Bernhard Küster, Susan F. Wheeler, Ann P. Hunter, Robert H. Bateman and Raymond A. Dwek. Electrophoretic and Mass Spectrometric Strategies for the Identification of Lipopolysaccharides and Immunodeterminants in Pathogenic Strains of Haemophilus influenzae: Application to Clinical Isolates, P. Thibault, J. Li, A.

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