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From The CriticsReviewer: Xiaochao Ma, PhD (University of Kansas Medical Center)
Description: This practical book covers the latest applications of mass spectrometry in drug absorption, distribution, metabolism, and excretion. The authors are experts in the fields of drug metabolism and pharmacokinetics from pharmaceutical companies, instrumental corporations, and universities.
Purpose: The purpose is to provide comprehensive information about mass spectrometry for solving complex problems in chemical analysis.
Audience: This book is valuable for scientists working in academic, industrial, and healthcare-related fields, who use mass spectrometry to investigate drug metabolism and pharmacokinetics, chemical markers of toxicity and disease, xenobiotic exposure, and so on.
Features: The 12 chapters can be characterized in one of three ways: 1) introducing the knowledge of mass spectrometry from the simple basics to the complex applications; 2) combining mass spectrometry techniques with the applications in drug metabolism and pharmacokinetics; 3) sharing of first-hand laboratory experience from leading experts around the world. The book begins with an overview of mass spectrometry in drug discovery and development and then details the applications of mass spectrometry in metabolites screening, identification, and quantification.
Assessment: In comparison to other books on mass spectrometry, this one not only provides both the basic and latest knowledge in mass spectrometry, but integrates the theory with applications to drug metabolism and pharmacokinetics. For instance, chapter 4, on the applications of quandrupole time-of- flight (Q-TOF) mass spectrometry in reactive metabolites screening, demonstrates the importance of exact mass measurements and high-resolution mass spectrometry in metabolites screening and identification. This chapter also introduces the MetaboLynx software, which could facilitate the identification of metabolites. This knowledge is very helpful for scientists in the metabolomic field.