Mass Spectrometry in Drug Metabolism and Pharmacokinetics [NOOK Book]


Inside this book are a host of practical tools and techniques that enable you to fully leverage the capabilities of mass spectrometry in order to get the most out of drug metabolism and pharmacokinetics studies. You'll learn the latest applications for determining how a drug is absorbed, distributed, metabolized, and excreted by the body.
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Mass Spectrometry in Drug Metabolism and Pharmacokinetics

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Inside this book are a host of practical tools and techniques that enable you to fully leverage the capabilities of mass spectrometry in order to get the most out of drug metabolism and pharmacokinetics studies. You'll learn the latest applications for determining how a drug is absorbed, distributed, metabolized, and excreted by the body.
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Editorial Reviews

From The Critics
Reviewer: Xiaochao Ma, PhD (University of Kansas Medical Center)
Description: This practical book covers the latest applications of mass spectrometry in drug absorption, distribution, metabolism, and excretion. The authors are experts in the fields of drug metabolism and pharmacokinetics from pharmaceutical companies, instrumental corporations, and universities.
Purpose: The purpose is to provide comprehensive information about mass spectrometry for solving complex problems in chemical analysis.
Audience: This book is valuable for scientists working in academic, industrial, and healthcare-related fields, who use mass spectrometry to investigate drug metabolism and pharmacokinetics, chemical markers of toxicity and disease, xenobiotic exposure, and so on.
Features: The 12 chapters can be characterized in one of three ways: 1) introducing the knowledge of mass spectrometry from the simple basics to the complex applications; 2) combining mass spectrometry techniques with the applications in drug metabolism and pharmacokinetics; 3) sharing of first-hand laboratory experience from leading experts around the world. The book begins with an overview of mass spectrometry in drug discovery and development and then details the applications of mass spectrometry in metabolites screening, identification, and quantification.
Assessment: In comparison to other books on mass spectrometry, this one not only provides both the basic and latest knowledge in mass spectrometry, but integrates the theory with applications to drug metabolism and pharmacokinetics. For instance, chapter 4, on the applications of quandrupole time-of- flight (Q-TOF) mass spectrometry in reactive metabolites screening, demonstrates the importance of exact mass measurements and high-resolution mass spectrometry in metabolites screening and identification. This chapter also introduces the MetaboLynx software, which could facilitate the identification of metabolites. This knowledge is very helpful for scientists in the metabolomic field.
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Product Details

  • ISBN-13: 9781118211571
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 9/20/2011
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 390
  • File size: 6 MB

Meet the Author

Ragu Ramanathan received a B.Sc. in Chemistry from the University of Southern Mississippi and a Ph.D. in Physical Chemistry/Mass Spectrometry from the University of Florida. His graduate research focused on coupling of electrospray ionization (ESI) to Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. After spending three years as a postdoctoral research fellow with Professor Michael L. Gross at the Washington University, St. Louis, Missouri, Dr. Ramanathan managed the Center for Advanced Mass Spectrometry at the Analytical Bio-Chemistry Laboratories, Columbia, Missouri. In 1998, Dr. Ramanathan joined Schering-Plough Research Institute’s (SPRI) Drug Metabolism and Pharmacokinetics (DMPK) Department and completed his tenure as a senior principal scientist in 2008. While at SPRI, Dr. Ramanathan was involved in the application of LC–MS for profiling and characterization of metabolites of drug candidates in the preclinical development and clinical stages. Dr. Ramanathan was with Pfizer Global Research and Development from 1999 to 2002 as a group leader of the Ann Arbor site biotransformation group. Dr. Ramanathan is currently an associate director at the Bristol-Myers Squibb, Co. and is responsible for elucidating biotransformation pathways of development drug candidates. Dr. Ramanathan’s accomplishments include 35 peer-reviewed papers, 10 book chapters, and over 60 oral/poster presentations. He also served as a chairperson for the North Jersey ACS Mass Spectrometry Discussion Group and as a chairman for DMPK sessions of the American Society for Mass Spectrometry and Eastern Analytical Symposium meetings.
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Table of Contents

1 Evolving Role of Mass Spectrometry in Drug Discovery and Development Dil M. Ramanathan Ramanathan, Dil M. Richard M. LeLacheur LeLacheur, Richard M. 1

2 Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications Ayman El-Kattan El-Kattan, Ayman Chris Holliman Holliman, Chris Lucinda H. Cohen Cohen, Lucinda H. 87

3 Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis Elliott B. Jones Jones, Elliott B. 123

4 Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening Jose M. Castro-Perez Castro-Perez, Jose M. 159

5 Changing Role of FTMS in Drug Metabolism Petia A. Shipkova Shipkova, Petia A. Jonathan L. Josephs Josephs, Jonathan L. Mark Sanders Sanders, Mark 191

6 High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection Haiying Zhang Zhang, Haiying Donglu Zhang Zhang, Donglu Mingshe Zhu Zhu, Mingshe Kenneth L. Ray Ray, Kenneth L. 223

7 Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies Wing W. Lam Lam, Wing W. Cho-Ming Loi Loi, Cho-Ming Angus Nedderman Nedderman, Angus Don Walker Walker, Don 253

8 Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants Paul H. Gamache Gamache, Paul H. David F. Meyer Meyer, David F. Michael C. Granger Granger, Michael C. Ian N. Acworth Acworth, Ian N. 275

9 LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine Natalia A. Penner Penner, Natalia A. Joanna Zgoda-Pols Zgoda-Pols, JoannaRagu Ramanathan Ramanathan, Ragu Swapan K. Chowdhury Chowdhury, Swapan K. Kevin B. Alton Alton, Kevin B. 295

10 Turbulent-Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification Joseph L. Herman Herman, Joseph L. Joseph M. Di Bussolo Di Bussolo, Joseph M. 311

11 Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules Jason S. Gobey Gobey, Jason S. John Janiszewski Janiszewski, John Mark J. Cole Cole, Mark J. 341

12 MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals Yunsheng Hsieh Hsieh, Yunsheng Walter A. Korfmacher Korfmacher, Walter A. 359

Index 383

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Customer Reviews

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( 4 )
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Sort by: Showing all of 4 Customer Reviews
  • Anonymous

    Posted March 17, 2014


    Not bad...

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  • Anonymous

    Posted March 17, 2014


    Eh.. okay i guess...

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  • Anonymous

    Posted March 17, 2014


    Tis ok

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  • Anonymous

    Posted March 17, 2014

    As the war began- Part one (Its horrible, MC!!)

    ••• Ponyville and Canterlot and cloudsdale were fighting for control. They all agreed on a war. Which ever team won this war would be claimed the most worthy town. Celestia did not approve of this war but she had to go along with it otherwise everypony may turn on her. Celestia bowed her head and sighed when they brought her the paper for her to sign. "Give it to me." The gaurds nodded and handed her the paper. With a wave of her hoof she sent the gaurds away. She was debating inside her head whether she should sign this paper or not. She just wanted all of this to end! Sighing she slowly wrote her signature. "I, Celestia daughter of princess Glaxia give my permission for this war." Celestia cringed when she heard herself. What was wrong with me?! Celestia cried softly. "Oh where did the peace go?" She closed her eyes and let herself drift off into her imagination.••• HOW WAS IT??!!

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