Mass Spectrometry in Molecular Biophysics: Conformation and Dynamics of Biomolecules / Edition 1

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Overview

"Recent advances in mass spectrometry (MS) have pushed the frontiers of analytical chemistry into the biophysical laboratory. As a result, the biophysical community's acceptance of MS-based methods, used to study protein higher-order structure and dynamics, has accelerated the expansion of biophysical MS." "Despite this growing trend, until now no single text has presented the full array of MS-based experimental techniques and strategies for biophysics. Mass Spectrometry in Biophysics expertly closes this gap in the literature." "Covering the theoretical background and technical aspects of each method, this much-needed reference offers an unparalleled overview of the current state of biophysical MS. Mass Spectrometry in Biophysics begins with a helpful discussion of general biophysical concepts and MS-related techniques." Fully referenced and containing a helpful appendix on the physics of electrospray mass spectrometry, Mass Spectrometry in Biophysics also offers a compelling look at the current challenges facing biomolecular MS and the potential applications that will likely shape its future.
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Product Details

  • ISBN-13: 9780471456025
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/14/2005
  • Series: Wiley Series on Mass Spectrometry Series , #12
  • Edition number: 1
  • Pages: 462
  • Product dimensions: 6.36 (w) x 9.47 (h) x 1.11 (d)

Table of Contents

1 General overview of basic concepts in molecular biophysics 1
2 Overview of "traditional" experimental arsenal to study biomolecular structure and dynamics 45
3 Overview of biological mass spectrometry 87
4 Mass spectrometry-based approaches to study biomolecular higher-order structure 143
5 Mass spectrometry-based approaches to study biomolecular dynamics : equilibrium intermediates 183
6 Kinetic studies by mass spectrometry 231
7 Protein interaction : a closer look at the "structure-dynamics-function" triad 268
8 Synergism between biophysical techniques 302
9 Other biopolymers and synthetic polymers of biological interest 324
10 Biomolecular ions in a solvent-free environment 357
11 Mass spectrometry on the march : where next? : from molecular biophysics to structural biology, perspectives and challenges 382
App Physics of electrospray 442
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  • Anonymous

    Posted May 23, 2005

    Great buy !!!!!

    This book is, without question, a 'one-stop-shop' for anyone who is interested in learning more about biological mass spectrometry at all levels. It is written in language to appease all readers, from the simple college student who encountered the term mass spectrometry in class to the expert mass spectrometrist who employs these tools from day to day. Eventhough I have worked in the field and do consider myself to be well read, I have learned quite alot from this book. Unlike other available books in the field, Kaltashov and Eyles did a spectacular job of bringing together pertinent historical information and background with theory, and a discussion of the present-day uses of mass spectrometry and an outlook on the future of mass spectrometry in biophysics. The text also wonderfully reflects how mass spectrometry can be complementary to other biophysical techniques. I highly recommend this text!

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