The Mast Cell in Health and Disease / Edition 1

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Offers coverage of practical and theoretical implications of current research into mast cell biology, emphasizing the role of the mast cell in human diseases. The text covers all aspects of the mast cell from growth and differentiation to its function in such conditions as asthma and skin disease.

This book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Offers comprehensive coverage of practical and theoretical implications of research regarding mast cell biology and the role of mast cells in such conditions as asthma, food allergy, and skin disease. Serves as both a reference and a clinical text, addressing topics ranging from basic biology and pharmacology to disease and its treatment. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780824787325
  • Publisher: Taylor & Francis
  • Publication date: 10/29/1992
  • Series: Lung Biology in Health and Disease Series, #62
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 858
  • Product dimensions: 6.25 (w) x 9.25 (h) x 0.75 (d)

Table of Contents

1 Human Mast Cells: Ultrastructural Observations of In Situ, Ex Vivo, and In Vitro Sites, Sources, and Systems 1
2 Structural Aspects of the High-Affinity Receptor for IgE 91
3 Mast Cell Secretagogues: Histamine-Releasing Factors and Neuropeptides 109
4 Insights into Mast Cell Development and Function Derived from Analyses of Mice Carrying Mutations at Beige, W/c-kit, or SI/SCF (c-kit Ligand) Loci 129
5 The Origin and Development of Murine and Human Mast Cells 203
6 Heterogeneity of Human Mast Cells 219
7 Development of Human Mast Cells from Umbilical Cord Blood Cells by Soluble Factors from 3T3 Fibroblasts 237
8 Molecular Characterization of Mouse Mast Cell Secretory Granule Proteases 247
9 Modulation of Mediator Release from Mast Cells 269
10 Lipid Metabolism and Mast Cell Activation 301
11 Histamine 321
12 Mast Cell Proteases 343
13 Mast Cell Proteoglycans 381
14 Leukotrienes 393
15 Kinins and Mast Cell-Related Diseases 415
16 Mast Cell Cytokines 443
17 Lessons to Be Learned from Sodium Cromoglycate and Related Drugs 467
18 The Effects of Anti-inflammatory Steroids on Mast Cells 483
19 Environmental Control: Evidence for a Direct Role of Allergens in Asthma and Allergic Disease 513
20 Anaphylaxis 529
21 The Pathophysiology of Allergic Rhinitis and Its Implications for Management 545
22 Mast Cells in Asthma 575
23 Mast Cell Involvement in Food Allergy 609
24 Urticaria: Characterization of Two Different Pathogenic Mechanisms 627
25 Do Mast Cells Play a Role in Atopic Dermatitis? 639
26 Mast Cells and Fibrosis: Hints from Graft-Versus-Host Disease and Scleroderma 653
27 Mast Cells and Their Role in Parasitic Helminth Infection 669
28 Mast Cells and the Nervous System 687
29 Mast Cells in Arthritis 699
30 Mast Cell Disease 723
31 Mast Cells, Stromal Cells, and Inflammation 743
32 Adhesion Receptors and Their Relevance to the Biology of Mast Cells and Basophils 763
Author Index 801
Subject Index 875
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