Mast Cells and Basophils - No 271: Development, Activation and Roles in Allergic/Autoimmune Disease / Edition 1by Novartis Foundation, Novartis Foundation Symposium Staff
Pub. Date: 11/29/2005
Delve into the latest research on mast cells and basophils and thier significance vis-a-vis multiple sclerosis, disbetes, HIV-1 infection, and other allergic and autoimmune diseases. This exciting new book covers recent advances relatiing to the factors and mechanisms that regulate the growth, differentiation, and function of mast cells and basophils. World leaders… See more details below
Delve into the latest research on mast cells and basophils and thier significance vis-a-vis multiple sclerosis, disbetes, HIV-1 infection, and other allergic and autoimmune diseases. This exciting new book covers recent advances relatiing to the factors and mechanisms that regulate the growth, differentiation, and function of mast cells and basophils. World leaders in the field describe new technologies used to study these cells. They aslo show how the basic scientific findings can be integrated into possible therapeutic applications. Some of the discussions examine the part played by mast cells in allergic inflammation and the effect that the stabilization of these cells has in novel therapies. There is also coverage of mastocytosis and the underlying mutations.
Table of Contents
Symposium on Mast cells and basophils: development, activation and roles in allergic/autoimmune disease, held at the Novartis Foundation, London, 16–18 November 2004
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium was based on a proposal made by Santa Jeremy Ono.
Santa Jeremy Ono: Chair’s Introduction.
Yukihiko Kitamura MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells
Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Mindy Tsai, Stephen J. Galli and Hans C. Oettgen: Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells
Yasuko Furumoto, Gregorio Gomez, Claudia Gonzalez-Espinosa, Martina Kovarova, Sandra Odom, John J. Ryan and Juan Rivera: The role of Src family kinases in mast cell effector function
Richard L. Stevens, Nasa Morokawa, Jing Wang and Steven A. Krilis: RasGRP4 in mast-cell signalling and disease susceptibility
J. Abramson, E. A. Barbu and I. Pecht: Regulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitization
General discussion I.
Toshiaki Kawakami, Jiro Kitaura, Wenbin Xiao and Yuko Kawakami: IgE regulation of mast cell survival and function
See-Ying Tam, Janet Kalesnikoff, Susumu Nakae, Mindy Tsai and Stephen J. Galli: RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation
Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Ricardo Micheler Richardson, Andrew Alban, Benjamin Leed, Dai Miyazaki and Santa Jeremy Ono: Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip technology
General discussion II.
Shigeo Koyasu, Akiko Minowa, Yasuo Terauchi, Takashi Kadowaki and Satoshi Matsuda: The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract
K. Frank Austen: The mast cell and the cysteinyl leukotrienes
Silvia Monticelli, K. Mark Ansel, Dong U. Lee and Anjana Rao: Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes
Cellina Cohen-Saidon and Ehud Razin: The involvement of Bcl-2 in mast cell apoptosis
General discussion III.
P. A. Nigrovic and D. M. Lee: Mast cells in autoantibody responses and arthritis
Greg D. Gregory, Allison Bickford, Michaela Robbie-Ryan, Mindy Tanzola and Melissa A. Brown: MASTering the immune response: mast cells in autoimmunity
Dean D. Metcalfe: Mastocytosis
Index of Contributors.
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