Mast Cells and Basophils - No 271: Development, Activation and Roles in Allergic/Autoimmune Disease / Edition 1

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The book presents recent advances relating to the factors and mechanisms that regulate the growth, differentiation and function of mast cells and basophils; discussion of new technologies used to study these cells, and integration of the basic scientific findings in the context of therapeutic possibilities for the treatment of diseases such as allergic inflammation and autoimmune disease which are mediated, in part, by these granulocytes.

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Editorial Reviews

Doody's Review Service
Reviewer: Mark C. Glaum, MD, PhD (University of South Florida College of Medicine)
Description: This book reviews the most recent research on the role of mast cells and basophils in allergic and autoimmune diseases. Topic reviews are followed by discussion among international experts in mast cell and basophil biology.
Purpose: The purpose is to provide basic researchers or clinicians with a concise, timely review of the factors and mechanisms regulating the growth, differentiation and function of mast cells and basophils. This is en ever-evolving field, therefore periodic updates in this area are needed. Emphasis is placed on new technologies used to study mast cell and basophil function, and attention is focused on how basic scientific observations can be translated into possible therapeutic applications.
Audience: Discussion is targeted to researchers and clinicians who have an interest in mast cell and basophil biology. Specialists most likely to use this book include allergists, clinical immunologists, rheumatologists, and dermatologists. Clinical and research fellows will also find it to be an excellent review of basic mechanisms of mast cell and basophil growth, differentiation, and activation.
Features: Each chapter is presented in the format of a topic review, which is followed by specific discussion of the topic among seminar panelists. A general discussion of the presented material is included every 3 to 5 chapters. The topics include: development of mast cells and basophils, IgE-mediated activation of mast cells and basophils, mechanisms of exocytosis, non-IgE-mediated activation and modulation of mast cells and basophils, description of mediators including those that are lipid-derived, proteases, proteoglycans and cytokines. Each chapter is well referenced and participant and subject indexes are included. The compact size of the book makes transport manageable.
Assessment: This is an excellent review of current research in mast cell and basophil biology. The discussion sections provide unique insight from world-recognized experts in the field. This is an excellent resource for clinicians or basic scientists with an interest in mast cells and related diseases.
From the Publisher
"This is an excellent resource for clinicians or basic scientists with an interest in mast cells and related diseases." (Doody's Health Services)
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Product Details

  • ISBN-13: 9780470013120
  • Publisher: Wiley
  • Publication date: 11/29/2005
  • Series: Novartis Foundation Symposia Series , #192
  • Edition number: 1
  • Pages: 274
  • Product dimensions: 6.20 (w) x 9.13 (h) x 0.72 (d)

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Table of Contents

Symposium on Mast cells and basophils: development, activation and roles in allergic/autoimmune disease, held at the Novartis Foundation, London, 16–18 November 2004
Editors: Derek J. Chadwick (Organizer) and Jamie Goode
This symposium was based on a proposal made by Santa Jeremy Ono.

Santa Jeremy Ono: Chair’s Introduction.

Yukihiko Kitamura MITF and SgIGSF: an essential transcription factor and its target adhesion molecule for development and survival of mast cells

Paul J. Bryce, Mendy L. Miller, Ichiro Miyajima, Mindy Tsai, Stephen J. Galli and Hans C. Oettgen: Immune sensitization in the skin is enhanced by antigen-independent effects of IgE on mast cells

Yasuko Furumoto, Gregorio Gomez, Claudia Gonzalez-Espinosa, Martina Kovarova, Sandra Odom, John J. Ryan and Juan Rivera: The role of Src family kinases in mast cell effector function

Richard L. Stevens, Nasa Morokawa, Jing Wang and Steven A. Krilis: RasGRP4 in mast-cell signalling and disease susceptibility

J. Abramson, E. A. Barbu and I. Pecht: Regulation of mast cell secretory response to the type I Fce receptor: inhibitory elements and desensitization

General discussion I.

Toshiaki Kawakami, Jiro Kitaura, Wenbin Xiao and Yuko Kawakami: IgE regulation of mast cell survival and function

See-Ying Tam, Janet Kalesnikoff, Susumu Nakae, Mindy Tsai and Stephen J. Galli: RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation

Masako Toda, Takao Nakamura, Masaharu Ohbayashi, Yoshifumi Ikeda, Maria Dawson, Ricardo Micheler Richardson, Andrew Alban, Benjamin Leed, Dai Miyazaki and Santa Jeremy Ono: Role of CC chemokines and their receptors in multiple aspects of mast cell biology: comparative protein profiling of FceRI- and/or CCR1-engaged mast cells using protein chip technology

General discussion II.

Shigeo Koyasu, Akiko Minowa, Yasuo Terauchi, Takashi Kadowaki and Satoshi Matsuda: The role of phosphoinositide-3-kinase in mast cell homing to the gastrointestinal tract

K. Frank Austen: The mast cell and the cysteinyl leukotrienes

Silvia Monticelli, K. Mark Ansel, Dong U. Lee and Anjana Rao: Regulation of gene expression in mast cells: micro-RNA expression and chromatin structural analysis of cytokine genes

Cellina Cohen-Saidon and Ehud Razin: The involvement of Bcl-2 in mast cell apoptosis

General discussion III.

P. A. Nigrovic and D. M. Lee: Mast cells in autoantibody responses and arthritis

Greg D. Gregory, Allison Bickford, Michaela Robbie-Ryan, Mindy Tanzola and Melissa A. Brown: MASTering the immune response: mast cells in autoimmunity

Dean D. Metcalfe: Mastocytosis

Index of Contributors.

Subject Index.

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