BN.com Gift Guide

Mathematical and Statistical Methods for Genetic Analysis

Overview

Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research.
This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.
Read More Show Less
... See more details below
Paperback (Softcover reprint of the original 2nd ed. 2002)
$111.37
BN.com price
(Save 10%)$124.00 List Price
Other sellers (Paperback)
  • All (5) from $91.95   
  • New (4) from $91.95   
  • Used (1) from $150.74   
Sending request ...

Overview

Written to equip students in the mathematical siences to understand and model the epidemiological and experimental data encountered in genetics research.
This second edition expands the original edition by over 100 pages and includes new material. Sprinkled throughout the chapters are many new problems.
Read More Show Less

Editorial Reviews

From the Publisher

From the reviews of the second edition:

"This book is an excellent resource for statisticians and applied mathematicians seeking an overview of models and formalisms in use in a wide collection of generic analysis processes." Journal of the American Statistical Association, June 2005

"Genetics is a subject that has always attracted the attention of statisticians back to the time that Mendel did his discoveries. … The current book realizes this and tries to provide a gentle introduction to a wide range of statistical topics in genetics. … I highly recommend this book for Master’s students wishing to see many interesting applications of statistics in genomics. On their way through this book, they will be rewarded with knowledge of a wide range of statistical topics." (Dr A. Di Bucchianico, Kwantitatieve Methoden, Vol. 72B38, 2006)

"More than 100 pages have been added in this Second Edition … . The strength of this book is that it provides the foundations and rigorous details of mathematical and statistical methodologies that are applied in genetics. … A nice feature of this book is that there are about a dozen problems for solution at the end of each chapter, which will be useful for the serious reader." (Partha P. Majumder, Sankhya, Vol. 65 (3), 2003)

"This monograph is the second edition of Lange’s 1997 work, increased by more than 100 pages. … Several chapters of the first edition have been supplemented by new material. … The book is intended for readers with basic knowledge in theoretical statistics, calculus and linear algebra. … Summarizing, this monograph can be recommended to all who want to connect their knowledge of mathematical statistics and genetics and learn about the statistical solutions … for genetical research problems." (C. Becker, Metrika, September, 2003)

"The second edition of this book by Ken Lange continues to present a very broad coverage of mathematical and statistical methods in the analysis of genetic data. The text has something to offer both mathematicians already experienced in genetics, as well as those with little experience in the area … . The book allows readers to appreciate the enormous contribution that Lange has made to the area and will hopefully inspire them (in Lange’s words) 'to create new models and methods for analyzing genetic data’." (Lyle C. Gurrin and John L. Hopper, Statistics in Medicine, Vol. 23, 2004)

"This is an excellent book written in the same crisp and clear style as the first edition. It has enough in detail of the underpinning genetics to allow the mathematicians and statisticians to gain an understanding sufficient to see the challenge and richness of the area. … It is both a useful reference source and a suitable introduction … . This is a book I am happy to recommend highly, and I look forward to the third edition in a few years time." (C Cannings, Heredity, Issue 92, 2004)

"The revolution in molecular genetics during the past decade has led to an avalanche of new data whose analysis requires increasingly sophisticated mathematical, statistical and computational methods. This book provides an up-to-date introduction to several of the most important mathematical and statistical methods developed for this purpose. … this is a major text that will be most useful for researchers and students of mathematics or statistics interested or engaged in the analysis of genetic data." (R. Bürger, Monatshefte für Mathematik, Vol. 139 (3), 2003)

"Mathematical and Statistical Methods for Genetic Analysis is written to equip students in the mathematical sciences to understand and model the epidemiological and experimental data encountered in genetics research. … Mathematical, statistical, and computational principles relevant to this task are developed … . Many specialized topics are covered that are currently accessible only in journal articles. This second edition expands the original edition by over 100 pages and includes new material … ." (Zentralblatt für Didaktik, June, 2002)

"The first edition of this book appeared in 1997 … and filled an important gap by covering in a unified setting topics dispersed in the research literature. This second edition is considerably larger, updating the first edition and adding some new topics. There are two new chapters … . Several new sections have also been added to existing chapters … ." (Carlos A. Braumann, Zentralblatt MATH, Vol. 991 (16), 2002)

Read More Show Less

Product Details

  • ISBN-13: 9781468495560
  • Publisher: Springer New York
  • Publication date: 8/28/2012
  • Series: Statistics for Biology and Health Series
  • Edition description: Softcover reprint of the original 2nd ed. 2002
  • Edition number: 2
  • Pages: 370
  • Product dimensions: 6.14 (w) x 9.21 (h) x 0.80 (d)

Table of Contents

Basic Principles of Population Genetics
• Counting Methods and the EM Algorithm
• Newton's Method and Scoring
• Hypothesis Testing and Categorical Data
• Genetic Identity Coefficients
• Applications of Identity Coefficients
• Computation of Mendelian Likelihoods
• The Polygenic Model
• Descent Graph Models
• Molecular Phylogeny
• Radiation Hybrid Mapping
• Models of Recombination
• Sequence Analysis
• Poisson Approximation
• Diffusion Processes
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)