Mathematical Foundations and Biomechanics of the Digestive System

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Mathematical modelling of physiological systems promises to advance our understanding of complex biological phenomena and pathophysiology of diseases. In this book, the authors adopt a mathematical approach to characterize and explain the functioning of the gastrointestinal system. Using the mathematical foundations of thin shell theory, the authors patiently and comprehensively guide the reader through the fundamental theoretical concepts, via step-by-step derivations and mathematical exercises, from basic theory to complex physiological models. Applications to nonlinear problems related to the biomechanics of abdominal viscera and the theoretical limitations are discussed. Special attention is given to questions of complex geometry of organs, effects of boundary conditions on pellet propulsion, as well as to clinical conditions, e.g. functional dyspepsia, intestinal dysrhythmias and the effect of drugs to treat motility disorders. With end of chapter problems, this book is ideal for bioengineers and applied mathematicians.

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Editorial Reviews

From the Publisher
'Biomedical engineers, gastrointestinal physiologists, medical physicists, and experts in drug discovery will find the insights and comprehensiveness of this mathematical modeling framework to have breakthrough potential … this book introduces a model that explains drug effects, their interactions, and reveals the mechanism for pathophysiological consequences of common disorders.' Michael W. Vannier, University of Chicago Medical Center

'This is the first book on the comprehensive modern solid mechanics of the digestive tract. … It will benefit students of later PhD courses and young investigators who are interested in the mechanics of digestive organs.' Takami Yamaguchi, Tohoku University

'The book is well written to meet the needs of modern topics on biomechanics of soft shells. … The presentation of material is rich in content, concise and straightforward.' Vladimir Kasyanov, Riga Technical University

'It provides a coherent framework for existing but fragmentary experimental and clinical observations, and it will surely lead to advances in pharmaceutical medicine, and ultimately in clinical diagnosis and therapy. … I predict that this will come to be seen as a landmark in this area of biomedicine.' David Wingate, Queen Mary University of London

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Product Details

  • ISBN-13: 9780521116626
  • Publisher: Cambridge University Press
  • Publication date: 4/30/2010
  • Pages: 240
  • Product dimensions: 7.00 (w) x 9.80 (h) x 0.60 (d)

Meet the Author

Roustem N. Miftahof is Professor and Head of the Department of Physiology at the Arabian Gulf University, Manama, Bahrain. He is a recognised leader in the areas of applied mathematics and gastrointestinal research, and has authored and co-authored two previous books in these fields. He has worked in both academia and industry across Europe, America and Asia.

Hong Gil Nam is Professor at Pohang University of Science and Technology, Pohang, South Korea, Director of the National Core Research Centre for Systems Bio-Dynamics and President of the Association of Asian Societies for Bioinformatics. Professor Nam has received numerous awards for his research contributions and he has made several media appearances in South Korea.

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Table of Contents

Preface; Notations; Introduction; 1. Geometry of the surface; 2. Parameterization of shells of complex geometry; 3. Nonlinear theory of thin shells; 4. Continuum model of the biological tissue; 5. Boundary conditions; 6. Soft shells; 7. Biomechanics of the stomach; 8. Biomechanics of the small intestine; 9. Biomechanics of the large intestine; 10. Biological applications of mathematical modeling; Index.

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