Mechanisms Of Cardiovascular Aging

Mechanisms Of Cardiovascular Aging

by T. Hagen
     
 

ISBN-10: 0444511598

ISBN-13: 9780444511591

Pub. Date: 12/01/2002

Publisher: Elsevier Science

This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these

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Overview

This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.

This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

Product Details

ISBN-13:
9780444511591
Publisher:
Elsevier Science
Publication date:
12/01/2002
Series:
Advances in Cell Aging and Gerontology Series, #11
Edition description:
1ST
Pages:
412
Product dimensions:
0.94(w) x 6.14(h) x 9.21(d)

Table of Contents

Preface
Ch. 1Overview of Cardiovascular Aging1
Ch. 2Lipoprotein Metabolism and Molecular Pathogenesis of Atherosclerosis23
Ch. 3Cytokines and the Pathogenesis of Atherosclerosis79
Ch. 4Endothelium-Mediated Signaling and Vascular Aging127
Ch. 5Nitric Oxide, Gender and Hypertension in Humans145
Ch. 6Alterations of Ion Channels in Vascular Muscle Cells and Endothelial Cells during Hypertension and Aging165
Ch. 7Extracellular Matrix Changes and Vascular Smooth Muscle Signaling183
Ch. 8Mitochondrial Electron Transport and Aging in the Heart201
Ch. 9Superoxide, Superoxide Dismutases, and Cardiovascular Dysfunction233
Ch. 10Aging and the Red Cell283
Ch. 11Hyperhomocysteinemia and Cardiovascular Aging309
Ch. 12Interactions of Selenium, Vitamin E, and Vitamin C in Atherosclerosis337
Ch. 13Dietary Antioxidants and Cardiovascular Disease349
Ch. 14Extension of Cardiovascular and Cerebrovascular Healthspan by Dietary Restriction: Molecular Mechanisms377
Contributor Addresses395

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