Mechanisms Of Cardiovascular Aging

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Overview

This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.

This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan.

This volume of Advances in Cell Aging and Gerontology provides a timely review on the molecular and cellular basis of cardiovascular diseases (CVD). Age itself is the leading risk factor for cardiovascular diseases, which include loss of vasomotor function, athero- and arterio-sclerosis, hypertension, congestive heart failure and stroke. Together these pathologies comprise the leading causes of permanent disability, hospitalization and death for individuals over the age of 65. Thus, there is a critical need to assess both the age-associated causes leading to CVD as well as the current state of knowledge on preventive regimens designed to slow or modulate disease progression.

This book concisely summarizes the current knowledge related to the major aspects contributing to cardiovascular disfunction in the elderly as well as potential ways of maintaining or improving human cardiovascular healthspan

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Product Details

Table of Contents

Preface
Ch. 1 Overview of Cardiovascular Aging 1
Ch. 2 Lipoprotein Metabolism and Molecular Pathogenesis of Atherosclerosis 23
Ch. 3 Cytokines and the Pathogenesis of Atherosclerosis 79
Ch. 4 Endothelium-Mediated Signaling and Vascular Aging 127
Ch. 5 Nitric Oxide, Gender and Hypertension in Humans 145
Ch. 6 Alterations of Ion Channels in Vascular Muscle Cells and Endothelial Cells during Hypertension and Aging 165
Ch. 7 Extracellular Matrix Changes and Vascular Smooth Muscle Signaling 183
Ch. 8 Mitochondrial Electron Transport and Aging in the Heart 201
Ch. 9 Superoxide, Superoxide Dismutases, and Cardiovascular Dysfunction 233
Ch. 10 Aging and the Red Cell 283
Ch. 11 Hyperhomocysteinemia and Cardiovascular Aging 309
Ch. 12 Interactions of Selenium, Vitamin E, and Vitamin C in Atherosclerosis 337
Ch. 13 Dietary Antioxidants and Cardiovascular Disease 349
Ch. 14 Extension of Cardiovascular and Cerebrovascular Healthspan by Dietary Restriction: Molecular Mechanisms 377
Contributor Addresses 395
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