Mechanisms of Cell-Mediated Cytotoxicity

Paperback (Softcover reprint of the original 1st ed. 1982)
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Product Details

  • ISBN-13: 9781468489613
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Advances in Experimental Medicine and Biology Series , #146
  • Edition description: Softcover reprint of the original 1st ed. 1982
  • Edition number: 1
  • Pages: 597
  • Product dimensions: 7.00 (w) x 10.00 (h) x 1.24 (d)

Table of Contents

Section I. Lysis by Cytotoxic T Lymphocytes: Morphological and Physiological Aspects.- Morphological Aspects of Lymphocyte Mediated Cytotoxicity.- Role of Cell Motility In the Activity of Cytolytic T Lymphocytes.- Discussion.- Cytolytic T Lymphocyte Recognition of Subcellular Antigen.- T Lymphocyte-Mediated Cytolysls - A Comprehensive Theory. I. The Mechanism of CTL — Mediated Cytolysls.- T Lymphocyte-Mediated Cytolysls — A Comprehensive Theory. IT. Lytic vs. Nonlytic Interactions of T Lymphocytes.- Discussion.- Studies on the Mechanism of Lectin-Dependent T Cell- Mediated Cytolysls: Use of Lens cullnarls Hemagglutinin A to Define the Role of Lectin.- Effects of Concanavalin A Pretreatment on Cloned Cytolytic T Cells.- Sequential Analysis of T Cell-Mediated Cytolysis: A Brief Reminder of Some Possibly Informative Markers at the Recognition and Lethal Hit Stages.- Discussion.- The Role of Calcium in the Lethal Hit of T Lymphocyte-Mediated Cytolysis.- Discussion.- Direct Analysis of Individual Killer T Cells: Susceptibility of Target Cells to Lysis and Secretion of Hydrolytic Enzjrmes by CTL.- Discussion.- The Differences in Receptor Cross Reactivity and Clonal Structure between Cytotoxic T Lymphocytes, Specific Suppressor T Cells and Memory T Cells Immune to Antigens of the H-2 Complex.- Section II. Lysis by Non-T Cells and by Complement.- Complement.- Membrane Attack by Complement (With Commen t s on Cell-Mediated Cytotoxicity).- Discussion.- ADCC.- Lymphocyte Mediated Cytolysis as a Secretory Phmiomenon.- Discussion.- Associative Recognition in ADCC.- Influence of Monovalent Cation Concentrations on Monocyte-Mediated ADCC.- Discussion.- MØCC.- Mechanisms of Macrophage-Mediated Tumor Cytolysis.- Discussion.- Activated Macrophage Mediated Cytotoxicity for Transformed Target Cells.- Discussion.- NKCC.- Overview on NK Cells and Possible Mechanisms for Their Cytotoxic Activity.- Distinctions between NK Cells and CTL.- A Search for Target Cell Structures Associated with Susceptibility to NK Cells.- Discussion.- Cell Surface Properties Influencing Target Cell Sensitivity for NK Lysis.- Discussion.- Soluble Cytotoxic Factors and the Mechanism of Cell Mediated Cytotoxicity.- Discussion.- Understanding the NK Cytolytic Process by Studying Mechanisms of Activation.- Discussion.- Mechanisms of Tumor Cell Lysis by Natural Killer Cells.- Discussion.- Sectiot III. The use of Antisera, Monoclcäial Antibodies, and Cloned Effector Cells in the Study of Cell-Mediated Cytolysis.- Somatic Cell Genetics of Cytolytic T Lymphocytes.- Discussion.- Lyt-2 Negative and T Cell Growth Factor Independent Cytotoxic T Lymphocyte Hybridomas.- Discussion.- The Molecular Basis for Cytolytic T Lymphocyte Function: Analysis with Blocking Monoclonal Antibodies.- Discussion.- Mechanism of T Cell-Mediated Cytolysis: An Investigation of Cells and Stages Affected by Cytolysis-Inhibiting Monoclonal Antibodies.- Functional Relationship of Lymphocyte Membrane Structures Probed with Cytolysis and/or Proliferation-Inhibiting H35-27.9 and H35-89.9 Monoclonal Antibodies.- Discussion.- Cytolytic T Cell Clones against H-2I Region Products: An Analysis Using Monoclonal Antibodies against la, Lyt-2 and P94,180 Cell Surface Antigens.- The Differential Effects of Distinct Cytolysis- Inhibiting Monoclonal Antibodies on Growth and on Cytolytic Activity of T Cell Clones.- Heterogeneity of Inhibition of Cytolytic T Lymphocyte Clones by Monoclonal Anti- Lyt-2/3 Antibodies: Parallel Effects on Cytolysis, Proliferation and Lymphokine Secretion.- Identification of Lysis-Relevant Molecules on the Surface of CTL: Primary Screening of Monoclonal Antibodies for the Capacity to Block Cytolysis by Cloned CTL Lines.- A Clone-Specific Monoclonal Antibody Which Inhibits T Cell-Mediated Cytolysis.- Inhibition of Human T Cell Mediated Cytolysis by Monoclonal Antibodies to Effector Cell Surface Structures.- Molecular Interactions in T-Cell Mediated Cytotoxicity: Discrimination between the Binding and Lethal Hit Stages of Cytolysis.- Discussion.- Participants.

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