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Doody's Review ServiceReviewer: Xiao Jian Sun, Ph.D.(University of Chicago Pritzker School of Medicine)
Description: This is a collection of reviews on the current understanding of the molecular mechanism of insulin action organized into 10 chapters based on different insulin actions. The book compiles the vast amount of molecular information that has been accumulated over the last 20 years of investigation into insulin action, particularly into the components of insulin signaling pathways. Each chapter is written by well known scientists and provides contemporary and up-to-date information.
Purpose: Insulin resistance is recognized as a major characteristic trait for type 2 diabetes. To understand the molecular basis for insulin resistance, the book reviews the current understanding of the molecular mechanism of insulin action. The first nine chapters address in detail the molecular aspects and the last chapter discusses the current understanding of insulin resistance. The authors have achieved what they set out to accomplish.
Audience: This book is written mainly for basic scientists who are interested in understanding the molecular details of insulin action. It is also appropriate for clinical scientists who are interested in pursuing their research at the molecular level.
Features: The molecular components, regulation, and signaling pathways for each insulin action are described. The unique feature is the molecular detail and the depth with which each topic is covered, which makes it an excellent reference book for insulin action. Most of the chapters end with a summary of future directions. The book is certainly a rich resource and valuable reference.
Assessment: This is an excellent reference that describes the molecular basis of insulin action. Each chapter is a discussion of a topic by a top scientist in the field with firsthand results and research. The chapters are current and go into significant depth. Though there is some redundancy in certain chapters, this is kept to a minimum.