Mechanisms of Insulin Action / Edition 1

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More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.

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Editorial Reviews

Doody's Review Service
Reviewer: Xiao Jian Sun, Ph.D.(University of Chicago Pritzker School of Medicine)
Description: This is a collection of reviews on the current understanding of the molecular mechanism of insulin action organized into 10 chapters based on different insulin actions. The book compiles the vast amount of molecular information that has been accumulated over the last 20 years of investigation into insulin action, particularly into the components of insulin signaling pathways. Each chapter is written by well known scientists and provides contemporary and up-to-date information.
Purpose: Insulin resistance is recognized as a major characteristic trait for type 2 diabetes. To understand the molecular basis for insulin resistance, the book reviews the current understanding of the molecular mechanism of insulin action. The first nine chapters address in detail the molecular aspects and the last chapter discusses the current understanding of insulin resistance. The authors have achieved what they set out to accomplish.
Audience: This book is written mainly for basic scientists who are interested in understanding the molecular details of insulin action. It is also appropriate for clinical scientists who are interested in pursuing their research at the molecular level.
Features: The molecular components, regulation, and signaling pathways for each insulin action are described. The unique feature is the molecular detail and the depth with which each topic is covered, which makes it an excellent reference book for insulin action. Most of the chapters end with a summary of future directions. The book is certainly a rich resource and valuable reference.
Assessment: This is an excellent reference that describes the molecular basis of insulin action. Each chapter is a discussion of a topic by a top scientist in the field with firsthand results and research. The chapters are current and go into significant depth. Though there is some redundancy in certain chapters, this is kept to a minimum.
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Product Details

  • ISBN-13: 9781441924698
  • Publisher: Springer New York
  • Publication date: 3/7/2011
  • Series: Medical Intelligence Unit Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2007
  • Edition number: 1
  • Pages: 214

Table of Contents

Insulin and IGF-I Receptor Structure and Binding Mechanism.- Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events.- Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis.- Control of Protein Synthesis by Insulin.- Hepatic Regulation of Fuel Metabolism.- Insulin Action Gene Regulation.- Insulin Action in the Islet—-Cell.- Central Regulation of Insulin Sensitivity.- Transgenic Models of Impaired Insulin Signaling.- Insulin Resistance.

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