Mechanisms of Lymphocyte Activation and Immune Regulation V: Molecular Basis of Signal Transduction / Edition 1

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''Well-organized and well-written....a valuable reference for teaching and as an introduction to the field.'' ---Advanstar Communication

The book contains black-and-white illustrations.

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Editorial Reviews

The 26 papers cover signaling by antigen receptors of B cells and of T cells, the signaling components of lymphocytes, signaling via Fc and cytokine receptors, and the molecular basis of x- linked immunodeficiencies. Of interest to basic immunologists and molecular biologists. Annotation c. Book News, Inc., Portland, OR (
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Product Details

Table of Contents

Signaling and Internalisation Function of the B Cell Antigen Receptor Complex 1
Mechanism of B Cell Antigen Receptor Function: Transmembrane Signaling and Triggering of Apoptosis 9
B-Cell Activation by Wild Type and Mutant Ig-[beta] Cytoplasmic Domains 23
Accessory Molecules Which Influence Signaling Through B Lymphocyte Antigen Receptors 35
Analysis of the (YXXL/I)2 Signalling Motifs Found in the Cytoplasmic Segment of the Mouse CD3[zeta] Chain 45
Molecular and Genetic Insights Into T Cell Antigen Receptor Signal Transduction 53
Signal Transduction During T Cell Development 63
The Regulation and Function of p21Ras in Signal Transduction by the T Cell Antigen Receptor 73
Immunological Tolerance by Antigen-Induced Apoptosis of Mature T Lymphocytes 81
Properties of Ca Currents Activated by T Cell Receptor Signaling 91
The Role of Syk in Cell Signaling 103
Nonreceptor Tyrosine Kinases in Aggregation-Mediated Cell Activation 111
Control of Lymphopoiesis by Non-Receptor Protein Tyrosine Kinases 121
Involvement of Nonreceptor Protein Tyrosine Kinases in Multichain Immune Recognition Receptor Signal Transduction 131
Phorbol Myristate Acetate-Induced Changes in Protein Kinase C Isozymes ([alpha], [beta], and [zeta]) in Human T Cell Subsets 143
Specific CD45 Isoforms Regulate T Cell Ontogeny and Are Functionally Distinct in Modifying Immune Activation 149
Cloning and Characterization of NF-AT[subscript c] and NF-AT[subscript p]: The Cytoplasmic Components of NF-AT 167
Quantitative Aspects of Receptor Aggregation 175
Fc Receptor Signaling 185
Proximal Signals and the Control of S-Phase Entry in Interleukin-2-Stimulated T Lymphocytes 197
The IL-4 Receptor - Signaling Mechanisms 211
Function of the Common [beta] Subunit of the GM-CSF/IL-3/IL-5 Receptors 217
Sharing of a Common [gamma] Chain, [actual symbol not reproducible] by the IL-2, IL-4, and IL-7 Receptors: Implications for X-Linked Severe Combined Immunodeficiency 225
X-Linked Agammaglobulinemia and Bruton's Tyrosine Kinase 233
The Role of CD40 Ligand in Human Disease 239
Involvement of the Protein Tyrosine Phosphatase PTP1C in Cellular Physiology, Autoimmunity and Oncogenesis 245
Contributors 255
Index 257
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